DENTAL FOLLICLE: ROLE IN DEVELOPMENT OF ODONTOGENIC CYSTS AND TUMOURS Dental Folikül: Odontojenik Kist ve Tümörlerin Oluşumundaki Rolü

Year 2014, Volume: 48 Issue: 1, 89 - 96, 08.04.2014

Amila Brkic

Abstract

ABSTRACT
Dental follicle is ecto-mesenchymal derived component of the tooth germ, adjacent to the crown of unerupted tooth. It has many roles during tooth development and eruption. During the impacted tooth surgery, pericoronal and dental follicular tissues are enucleating. However, in rare cases they are submitting for histopathologic evaluation, although it is known, that these tissues are responsible for the occurrence and development of pathologic conditions, such as infections, odontogenic cysts, and tumors.Dental follicle was the subject of many immunohistochemical studies, which have shown a proliferative potential of the dental follicle cells justifying a profilactic removal of the impacted teeth.
According to review of relevant literature, the aim of this article is to describe and discuss importance of dental follicle in oral and maxillofacial surgery.
Kerwords: Dental follicle, dentigerous cyst, impacted tooth, stem cells
ÖZ
Dental folikül diş germini ektomezenkimal bağ dokusundan oluşturan, dişin kronun etrafında olan ve diş gelişiminde ve sürmesinde önemli rol oynayan yapıdır. Gömük7 diş operasyonu sırasında, pe-rikoronal ve dental folikül dokuları enükle edilmektedir. Ancak bu dokuları, enfeksiyon, odontojenik kist ve tümör gibi patolojik durumların gelişiminden sorumlu olduğu halde, nadiren histopatolojik incelemeleri yapılmaktadır. Pek çok immunohistokimyasal çalışmalar dental folikülü incelerken, onun proliferatif potensiyelini göstererek, gömük dişlerin profilaktik çekimlerini önermektedir. Konu ile ilgili literatüre göre, bu derlemenin amacı dental folikülün oral ve maksillofasyal cerrahisinde önemli rol olduğunu göstermektir.
Anahtar kelimeler: Dental folikül, dentigeröz kist, gömük diş, kök hücreler

Keywords

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Dental Folikül: Odontojenik Kist ve Tümörlerin Oluşumundaki Rolü

Abstract

Dental folikül diş germini ektomezenkimal bağ dokusundan oluşturan, dişin kronun etrafında olan ve diş gelişiminde ve sürmesinde önemli rol oynayan yapıdır. Gömük7 diş operasyonu sırasında, perikoronal ve dental folikül dokuları enükle edilmektedir. Ancak bu dokuları, enfeksiyon, odontojenik kist ve tümör gibi patolojik durumların gelişiminden sorumlu olduğu halde, nadiren histopatolojik incelemeleri yapılmaktadır. Pek çok immunohistokimyasal çalışmalar dental folikülü incelerken, onun proliferatif potensiyelini göstererek, gömük dişlerin profilaktik çekimlerini önermektedir. Konu ile ilgili literatüre göre, bu derlemenin amacı dental folikülün oral ve maksillofasyal cerrahisinde önemli rol olduğunu göstermektir.

Keywords

Dental folikül, dentigeröz kist, gömük diş, kök hücreler

References

• Avery JK. Oral Development and Histology. 3th ed., New York: Thieme Medical Publishers, 2002, p.131. Lindroos B, Maenpaa K, Ylikomi T, Oja H, Suuronen R, Miettinen S. Characterisation of human dental stem cells and buccal mucosa fibroblasts. Biochem Biophys Res
• Commun 2008;368(2):329-35. Razavi SM, Hasheminia D, Mehdizade
• M, Movahedian B, Keshani F. The relation of pericoronal third molar follicle dimension and bcl-2/ki-67 expression: an immunohistochemical study. Dent Res J (Isfahan). 2012;9(Suppl 1):S26-31. Mori G, Ballini A, Carbone C, Oranger
• A, Brunetti G, Di Benedetto A, Rapone B, Cantore S, Di Comite M, Colucci S, Grano M, Grassi FR. Osteogenic differentiation of dental follicle stem cells. Int J Med Sci 2012;9(6):480-7. Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Möhl C, Sippel C, Hoffmann KH. Isolation of precursor cells
• (PCs) from human dental follicle of wisdom teeth. Matrix Biol 2005;24(2):155-65. Brkić A, Mutlu S, Koçak-Berberoğlu
• H, Olgaç V. Pathological changes and immunoexpression of p63 gene in dental follicles of asymptomatic impacted lower third molars: an immunohistochemical study. J Craniofac Surg 2010;21(3):854-7. Dai Y, He H, Wise GE, Yao S. Hypoxia promotes growth of stem cells in dental follicle cell populations. J Biomed Sci Eng 2011;4(6):454-61. Schiraldi C, Stellavato A, D’Agostino
• A, Tirino V, d’Aquino R, Woloszyk A, De Rosa A, Laino L, Papaccio G, Mitsiadis TA. Fighting for territories: time-lapse analysis of dental pulp and dental follicle stem cells in co-culture reveals specific migratory capabilities. Eur Cell Mater 2012;24:426-40. Davis WL. Oral histology cell structure and function. Philadelphia, PA: Saunders, 1986, p.59-60.
• Liu D, Yao S, Wise GE. Regulation of SFRP-1 expression in the rat dental follicle. Connect Tissue Res 2012;53(5):366-72.
• Marks SC, Jr, Cahill DR, Wise GE. The cytology of the dental follicle and adjacent alveolar bone during tooth eruption in the dog. Am J Anat 1983;168(3):277–89. Peterson, LJ, Ellis, E III, Hupp, JR, Tucker, MR. Contemporary oral and maxillofacial surgery, 4th ed., St. Louis: Mosby, 200
• Slater LJ. Comments on “pathologic changes in the soft tissues associated with asymptomatic impacted third molars”. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107(1):5. doi: 10.1016/j.tripleo.2008.08.055. Epub 2008 Nov 18.
• Kim SG, Kim MH, Chae CH, Jung YK, Choi JY. Downregulation of matrix metalloproteinases in hyperplastic dental follicles results in abnormal tooth eruption. BMB Rep 2008;41(4):322-7.
• Jamshidi S, Zargaran M, Mohtasham N. Multiple Calcifying Hyperplastic Dental Follicle (MCHDF): a case report. J Dent Res Dent Clin Dent Prospects 2013;7(3):174-6. Sandler HJ, Nersasian RR, Cataldo E, Pochebit S, Dayal Y. Multiple dental follicles with odontogenic fibroma-like changes (WHO-type). Oral Surg Oral Med Oral Pathol 1988;66(1):78–84.
• Lukinmaa P, Hietanen J, Anttinen J, Ahonen P. Contiguous enlarged dental follicles with histologic features resembling the WHO type of odontogenic fibroma. Oral Surg Oral Med Oral Pathol 1990;70(3):313–
• Saravana GH, Subhashraj K. Cystic changes in dental follicle associated with radiographically normal impacted mandibular third molar. Br J Oral Maxillofac Surg 2008;46(7):552–3. Al-Khateeb TH, Bataineh AB. Pathology associated with impacted mandibular third molars in a group of Jordanians. J Oral
• Maxillofac Surg 2006;64(11):1598-602. Mesgarzadeh AH, Esmailzadeh H, Abdolrahimi M, Shahamfar M. Pathosis associated with radiographically normal follicular tissues in third molar impactions: a clinicopathological study. Indian J Dent Res 2008;19(3):208-12. Ide F, Shimoyama T, Horie N, Kaneko T. Primary intraosseous carcinoma of the mandible with probable origin from reduced enamel epithelium. J Oral Pathol Med 1999;28(9):420-2. Shimoyama T, Ide F, Horie N, Kato
• T, Nasu D, Kaneko T, Kusama K. Primary intraosseous carcinoma associated with impacted third molar of the mandible: review of the literature and report of a new case. J Oral Sci 2001;43(4):287-92. Leitner C, Hoffmann J, Kröber S, Reinert S. Low-grade malignant fibrosarcoma of the dental follicle of an unerupted third molar without clinical evidence of any follicular lesion. J Craniomaxillofac Surg 2007;35(1):48-51. Koçak H, Timoçin N, Öz F, Uraz
• S. Gömük alt akıl dişi çevre dokularının histopatolojik ve immunohistokimyasal değerlendirmesi. İstanbul Üniv Diş Hek Fak Derg 1994;28(1)83–6. Moure SP, Carrard VC, Lauxen IS, Manso PP, Oliveira MG, Martins MD, Sant
• Ana Filho M. Collagen and elastic fibers in odontogenic entities: analysis using light and confocal laser microscopic methods. Open Dent J 2011;5:116-21. Baykul T, Saglam AA, Aydin U, Başak
• K. Incidence of cystic changes in radiologically normal impacted lower third molar follicles. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99(5):542-5.
• Yildirim G, Ataoğlu H, Mihmanli A, Kiziloğlu D, Avunduk MC. Pathologic changes in soft tissues associated with asymptomatic impacted third molars. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106(1):14-8.
• Simşek-Kaya G, Özbek E, Kalkan Y, Yapici G, Dayi E, Demirci T. Soft tissue pathosis associated with asymptomatic impacted lower third molars. Med Oral Patol Oral Cir Bucal 2011;16(7):e929-36.
• Knutsson K, Brehmer B, Lysell L, Rohlin M. Pathoses associated with mandibular third molars subjected to removal. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82(1):10-7.
• Matsumoto MA, Filho HN, Jorge FM, Salvadori DM, Marques ME, Ribeiro DA. Expression of cell cycle regulatory proteins in epithelial components of dental follicles. J Mol Histol 2006;37(3-4):127-31. da Silva Baumgart C, da Silva Lauxen I, Filho MS, de Quadros OF. Epidermal growth factor receptor distribution in pericoronal follicles: relationship with the origin of odontogenic cysts and tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103(2):240-5.
• Fantoni G, Barni T, Gloria L, Repice F, Bellone C, Vannelli GB. Characterization and localization of epidermal growth factor receptors in human developing tooth. Ital J Anat Embryol 1997;102(1):21-32.
• Shroff B, Kashner JE, Keyser JD, Hebert C, Norris K. Epidermal growth factor and epidermal growth factor-receptor expression in the mouse dental follicle during tooth eruption. Arch Oral Biol 1996;41(6):613-7. Edamatsu M, Kumamoto H, Ooya K, Echigo S. Apoptosis-related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible. Oral Surg
• Oral Med Oral Pathol Oral Radiol Endod 2005;99(1):17-23. Cabbar F, Guler N, Comunoglu N, Cöloglu S. Determination of potential cellular proliferation in the odontogenic epithelia of the dental follicle of the asymptomatic impacted third molars. J Oral Maxillofac
• Surg 2008;66(10):2004-11. Adelsperger J, Campbell JH, Coates
• DB, Summerlin DJ, Tomich CE. Early soft tissue pathosis associated with impacted third molars without pericoronal radiolucency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89(4):402-6. Saraçoğlu U, Kurt B, Günhan O, Güven O. MIB-1 expression in odontogenic epithelial rests, epithelium of healthy oral mucosa and epithelium of selected odontogenic cysts. An immunohistochemical study.
• Int J Oral Maxillofac Surg 2005;34(4):432-5. Güler N, Comunoğlu N, Cabbar F.
• Ki-67 and MCM-2 indental follicle and odontogenic cysts: the effects of inflammation on proliferative markers. ScientificWorldJournal 2012;2012:946060. doi: 1100/2012/946060. Epub 2012 Jun 18. Tekin U, Kısa Ü, Güven O, Kurku H.
• Malondialdehyde levels in dental follicles of asymptomatic impacted third molars. J Oral Maxillofac Surg 2011;69(5):1291-4. Adeyemo WL. Do pathologies associated with impacted lower third molars justify prophylactic removal? A critical review of the literature. Oral Surg Oral Med Oral
• Pathol Oral Radiol Endod 2006;102(4):448Assael LA. Impacted teeth: reflections on Curran, Kugelberg, and Rood. J Oral
• Maxillofac Surg 2002;60(6):611–2. Kotrashetti VS, Kale AD, Bhalaerao SS, Hallikeremath SR. Histopathologic changes in soft tissue associated with radiographically normal impacted third molars. Indian J Dent Res 2010;21(3):385-90. de Oliveira DM, de Souza Andrade ES, da Silveira MM, Camargo IB. Correlation of the radiographic and morphological features of the dental follicle of third molars with incomplete root formation. Int J Med Sci 2008;5(1):36-40.
• Corresponding Author: Amila BRKİĆ Fra AndjelaZvizdovića 8, 71000 Sarajevo
• Bosnia and Herzegovinia e-mail: [e-mail]