Leukocyte and Platelet Rich Fibrin: Characteristics and Clinical Applications in Dentistry

Year 2014, Volume: 48 Issue: 2, 73 - 83, 27.06.2014

Gülnihal Eren Gül Atilla

Abstract

Several platelet concentrates are avaliable in different techniques; however, their biological contents vary from one to another. Leukocyte platelet-rich fibrin (L-PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. Although plateletderived growth factors play an important role in biology of PRF, fibrin organization and the leukocyte content are other two key variables. Due to the growth factor and cell content, L-PRF has a positive effect on natural wound healing. Frequency of L-PRF usage in dentistry is increasing, because of its positive effects on soft tissue and bone healing.

Keywords

Platelet rich fibrin, wound healing, growth factor, cytokine, regeneration

LÖKOSİT VE TROMBOSİTTEN ZENGİN FİBRİNİN ÖZELLİKLERİ VE DİŞ HEKİMLİĞİNDE KULLANIM ALANLARI

Abstract

Günümüzde çeşitli tekniklerle elde edilen farklı trombosit konsantrasyonları bulunmaktadır. Benzer
isimlerle anılsa bile, bu konsantrasyonların biyolojik içerikleri farklıdır. Lökosit ve trombositten zengin
fibrin (L-TZF), kan kaynaklı trombosit konsantrasyonları arasında en son geliştirilenidir. Herhangi bir
antikoagülan ajana gerek duyulmadan hazırlanan L-TZF’nin eldesi kolaydır. L-TZF’nin biyolojisinde
her ne kadar trombosit kaynaklı büyüme faktörleri önemli bir rol oynasa da, fibrin organizasyonu ve
lökosit içeriği de diğer iki anahtar değişkenini oluşturur. Bu nedenle L-TZF, içeriğinde bulunan büyüme
faktörleri ve hücreler sayesinde doğal yara iyileşmesini olumlu yönde etkiler. Yumuşak doku ve kemik
iyileşmesi üzerindeki olumlu özellikleri nedeniyle günümüzde L-TZF’nin diş hekimliği alanında kullanım
sıklığı giderek artmaktadır.

Keywords

Trombositten zengin fibrin, yara iyileşmesi, büyüme faktörü, sitokin, rejenerasyon

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