Clinical Manifestation and Characteristics of COVID-19 in Pregnants: A Retrospective, Single-Center Study

Abstract

Objectives: Along with the COVID-19 pandemic, pregnant women have experienced COVID-19 symptoms of varying severity. Therefore, we aimed to show the clinical, laboratory, and radiological findings for three different trimesters in pregnant women diagnosed with COVID-19. Methods: All hospitalized pregnant women with positive SARS-CoV-2 nucleic acid tests were included in this study. The severity of the disease was classified using the NIH Classification of Severity of Disease. Results: None of the 206 participants were vaccinated. The number of asymptomatic or presymptomatic patients, those with mild, moderate, and severe disease, was 73(35.4%), 59(28.6%), 68 (33.1%), and 6 (2.9%), respectively. The gestational age of symptomatic patients was lower than that of asymptomatic patients (29 vs. 37 weeks) (p= 0.001). The incidence of pneumonia increased with the trimester of pregnancy increased (p<0.001). Sixty-six of the pregnancies (32.0%) ended with term births, and 11 (0.5%) gave premature birth. Three pregnancies resulted in miscarriage (1.4%), and one(0.4%) resulted in intrauterine fetal death. Of the preterm deliveries, nine(64.3%) had pneumonia. There was no significant relationship between the disease severity and delivery time (p=0.075), but a significant relationship between the disease severity and the delivery mode. Expected vaginal delivery occurred in 18 asymptomatic patients (72%), whereas cesarian/section was performed in 75.6% (n=31) of symptomatic patients (p<0.001). Conclusion: This study reflects the natural course of COVID-19 since our patients were not vaccinated. We think the results will be better with the increase in vaccination rates.

Keywords

• Pregnancy
• COVID-19
• Pandemic
• Pneumonia

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