Drug interaction of bocepravir and amlodipine in a patient with hepatitis C: A Cardiovascular follow-up

Abstract

Boceprevir is a NS3/4A hepatitis C virus (HCV) protease inhibitor, used in combination with peginterferon and ribavirin to treat HCV. Boceprevir undergoes extensive metabolism via cytochrome P450-mediated oxidation and ketoreduction by cytosolic aldo-keto reductases. Amlodipine has been used for the treatment of patients with hypertension and also metabolised through cytochrome P450 pathway. Here, we presented a case of boceprevir and amlodipine interaction in a patient with chronic HCV and her echocardiography and electrocardiographic follow-up results.

Keywords

• Amlodipine, boceprevir, drug ınteraction

Drug interaction of bocepravir and amlodipine in a patient with hepatitis C: A Cardiovascular follow-up

Öz

Boceprevir, Hepatit C virüs (HCV) enfeksiyonunun tedavisinde peginterferon ve ribavirin ile kombine edilerek kullanılan NS3/4A HCV proteaz inhibitörüdür. Boceprevir, büyük çoğunlukla sitokrom P450 ilişkili oksidasyon ve sitozolik aldo-keto redüktaz ile ketoredüksiyon yoluyla metabolize olur. Amlodipin hipertansiyonu olan hastaların tedavisinde kullanılmaktadır ve amlodipin de sitokrom P450 yoluyla metabolize olur. Bu yazıda, boceprevir ve amlodipin kronik HCV enfeksiyonu olan bir hastadaki etkileşimini ve bu hastanın ekokardiyografik ve elektrokardiyografik takip sonuçlarını sunduk

Anahtar Kelimeler

• Amlodipin, boceprevir, ilaç etkileşimi

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