Tularemia (Rabbit Fever)

Öz

Tularemi, aerop, hareketsiz, sporsuz, gram negatif bir basil olan Francisella tularensis’in neden olduğu zoonotik bir hastalıktır. İnsanlara, enfekte bir hayvanın işlenmesi, enfekte hayvanın vücut sıvılarıyla temas, kontamine su veya besinlerin yenmesi, içilmesi aerosollerin solunması ya da kene ısırığı ile bulaşır. Kültür işlemi sırasında kolayca bulaşmasına rağmen, insandan insana bulaşmaz

Anahtar Kelimeler

• Tularemi, Francisella tularensis, tavşan ateşi

Tularemia (Rabbit Fever)

Abstract

Tularemia is a zoonotic disease caused by Francisella tularensis, an aerobic, sedentary and non-sporing gram negative bacillus. It is transmitted to people via the handling of an infected animal, contact with the body fluids of an infected animals, eating, drinking contaminated water or food, breathing aerosols or tick bite. Even though it is easily transmitted during the culture process, it is not transmitted human-to-human.

Keywords

• Tularemia, Francisella tularensis, rabbit fever. Tularemi (Tavşan Ateşi

References

1. Lindquist D, Chu MD, Probert WS. Francisella and Brucella. In: Murray PR, Baron EJ, Jorgensen JH, et al ed. Manual of Clinical Microbiology, 9th ed. Washington, DC: American Society for Microbiology Press; 2007:815-834.
2. Staples JE, Kubota KA, Chalcraft LG, et al. Epidemiologic and molecular analysis of human tularemia, United States, 1964- 2004. Emerg Infect Dis 2006;12:1113-1118.
3. Health Aspects of Chemical and Biologic Weapons. Geneva, Switzerland: World Health Organization. 1970:105-107.
4. Leblebicioglu H, Esen S, Turan D, et al. Outbreak of tularemia: a case-control study and environmental investigation in Tur- key. Int J Infect Dis 2008;12:265-269.
5. Tärnvik A, Berglund L. Tularaemia. Eur Respir J 2003;21:361- 373.
6. Morner T. The ecology of tularemia. Rev Sci Tech 1992;11:1123- 1130
7. Pearson AP. Tularemia. In Palmer SR. Lord Soulsby, Simpson DIH (eds), Zoonoses: biology, clinical practice, and public health control. Oxford University Pres, Oxford. 1998:267- 280.
8. Vaissaire J, Mendy C, Le Doujet C, Le Coustumier A. Tulare- mia. The disease and its epidemiology in France. Med Mal Infect 2005;35:273-280.

9. Plevnelioğlu KH. Memleketimizde tularemi. Tedavi Kliniği ve Laoratuvarı Dergisi 1936;6:119-135.
10. Kılıçturgay K, Gökırmak F, Gedikoğlu S, et al. Bursa’da tula- remia epidemisi. İnfeksiyon Dergisi 1989;3:149-156.
11. Helvacı S, Gedikoğlu S, Akalın H, Oral HB. Tularemia in Bursa, Turkey: 205 cases in ten years. Eur J Epidemiol 2000;16:271-276.
12. Karadenizli A, Gurcan S, Kolayli F, Vahaboglu H. Outbreak of tularaemia in Gölcük, Turkey in 2005: report of 5 cases and an overview of the literature from Turkey. Scand J Infect Dis. 2005;37:712-716.
13. Erbay A, Dokuzoğuz B, Baykam N, et al. Ankara yöresinde Tularemi. Turkish Journal of Infection 2000;14:453-458.
14. Penn RL. Francisella tularensis (Tularemia). In: Principles and Practice of Infectious Diseases, 7th Ed, Mandell GL, Ben- nett JE, Dolin R. (Eds), Churchill Livingstone, Philadelphia 2010:2927-2937.
15. Evans ME, Gregory DW, Schaffner W, McGee ZA. Tularemia: a 30-year experience with 88 casesMedicine (Baltimore). 1985;64:251-69.
16. Gürcan Ş, Otkun MT, Otkun M, Arıkan OK, Özer B. An out- break of tularemia in Western Black Sea region of Turkey. Yonsei Med J 2004;45:17-22.
17. Sencan I, Sahin I, Kaya D, et al. 2009. An outbreak of oro- pharyngeal tularemia with cervical adenopathy predominant- ly in the left side. Yonsei Med J 2009;50:50-54.
18. Siret V, Barataud D, Prat M, et al. An outbreak of airborne tu- laraemia in France, August 2004. Euro Surveill 2006;11:58- 60.
19. Pettersson T, Nyberg P, Nordström D, Riska H. Similar pleu- ral fluid findings in pleuropulmonary tularemia and tubercu- lous pleurisy. Chest 1996; 109:572-575.
20. Penn RL, Kinasewitz GT. Factors associated with a poor out- come in tularemia. Arch Intern Med 1987;147:265-268.
21. Tärnvik A, Chu MC. New approaches to diagnosis and thera- py of tularemia. Ann N Y Acad Sci 2007;1105:378-404.
22. Hassoun A, Spera R, Dunkel J. Tularemia and once-daily gentamicin. Antimicrob Agents Chemother 2006;50:824.
23. Hofinger DM, Cardona L, Mertz GJ, Davis LE. Tularemic meningitis in the United States. Arch Neurol 2009;66:523- 527.
24. Cross JT, Jacobs RF. Tularemia: treatment failures with out- patient use of ceftriaxone. Clin Infect Dis 1993;17:976-980.
25. Dennis DT, Inglesby TV, Henderson DA, et al. Tularemia as a biological weapon: medical and public health management. JAMA 2001;285:2763-2773.