Prevalence of carbapenem resistant Enterobacteriaceae from a tertiary care hospital in Mumbai, India

Abstract

Objective: The emergence of Carbapenem Resistant Enterobacteriaceae (CRE) in recent times has become a serious threat to public health due to the high mortality, potential dissemination rates and limited treatment options associated with these organisms. Thus, the present study was conducted in our tertiary care hospital in Mumbai, to retrospectively analyze the prevalence of CRE in the hospital. Methods: The study was carried out in the microbiology department of the tertiary care hospital over a period of 12 months. The samples tested were clinical samples from hospitalized and Out-Patient Department (OPD) patients sent to the department for microbiological testing. CRE isolates were identified using the Vitek 2- Compact system (BioMérieux, France). Results: A CRE prevalence rate of 12.26% was obtained from the study, from which the majority of the isolates were detected in urine samples (46%). Although most of the CRE isolates were detected in patient samples from the wards (42%) and the ICU (26%), a significant number of isolates was also detected from the OPD patients (19%). Conclusion: Thus, the study shows a significant rate of carbapenem resistance among Enterobacteriaceae isolated from hospitalized and OPD patients. This emphasizes the urgent need for CRE control at the hospital and community level, and to rationalize the use of antibiotics.

Keywords

• Carbapenem Resistant Enterobacteriaceae

Prevalence of carbapenem resistant Enterobacteriaceae from a tertiary care hospital in Mumbai, India

Öz

Amaç: Karbapenem dirençli Enterobacteriaceae (CRE) enfeksiyonlarındaki artış halk sağlığı için önemli bir tehdit oluşturmaktadır çünkü bu bakterilerin enfeksiyonlarında kullanılabilecek sınırlı sayıda antibiyotik vardır ve mortalitesi yüksektir. Bu çalışma, Mumbai’de bulunan üçüncü basamak hizmet veren merkezimizde CRE prevalansını belirlemek amacıyla retrospektif olarak yapıldı.Yöntemler: Çalışma mikrobiyoloji bölümünde 12 aylık bir sürede yapıldı. Hem hastane kökenli hem de toplum kaynaklı örnekler çalışmaya dahil edilmiştir. Örnekler Vitek 2- Compact System (BioMérieux, France) ile analiz edildi.Bulgular: Çalışmamızda CRE sıklığı %12.26olarak bulunmuş olup örneklerin büyük bir kısmı idrar (% 46) örneklerinden elde edildi. Ancak CRE izole edilen örneklerin önemli bir kısmı yara örneklerinden (% 42) idi. Örneklerin % 26’sı yoğun bakım hastalarından izole edilirken %19’u da toplum kaynaklı örneklerden izole edildi. Sonuç: Çalışmamızda Enterobacteriaceae üyelerinin önemli bir kısmında karbapenem direnci olduğu gösterilmiştir. CRE kökenlerinin toplumda ve hastanede kontrol edilmesini sağlayacak önlemlere ve akılcı antibiyotik kullanımı sağlayacak tedbirlere ihtiyaç vardır

Anahtar Kelimeler

• Karbapenem Dirençli Enterobacteriaceae, Antibiyotik yönetimi

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