Helicobacter pylori in primary gastric lymphoma and gastric cancer: A clinicopathologic and prognostic assessment

Abstract

Objectives: Helicobacter pylori infection is a risk factor for gastric adenocarcinoma and primary gastric lymphoma. We examined whether this H.pylori infection is also a prognostic factor for gastric cancer and primary gastric lymphoma. Methods: Resected or biopsied specimens from 255 patients with gastric adenocarcinoma and primary gastric lym&shy;phoma were investigated for H.pylori status. Hematoxylin and eosin stain was used to evaluate the presence or absence of H.pylori on formalin fixed, paraffin embedded specimens. Results: H.pylori were detected in 34 of 140 patients (24.3%) with primary gastric lymphoma, while H.pylori were de&shy;tected in 62 of 115 patients (53.9%) with gastric cancer. The frequency of H.pylori positivity was higher in patients with gastric cancer than in those with gastric lymphoma (p<0.001). The frequency of H.pylori positivity was different between mucosa-associated lymphoid tissue type (MALT) lymphomas (53.5%) and lymphomas other than diffuse large b-cell lymphoma (DLBCL) (18.7%) in gastric lymphoma (p<0.001). For patients with primary gastric lymphoma, H.pylori status did not correlate with the disease free survival and overall survival (p=0.833, p= 0.503). However for patients with gastric cancer, H.pylori status did not correlate with the disease- free survival and overall survival (p=0.392, p= 0.357). Conclusions: In our study, between gastric cancer and primary gastric lymphoma were significant differences in terms of the presence of H.pylori. However, H.pylori did not have prognostic significance on survival for both pairs.

Keywords

• H.pylori

Helicobacter pylori in primary gastric lymphoma and gastric cancer: A clinicopathologic and prognostic assessment

Öz

Amaç: Helicobacter pylori mide lenfoması ve adenokarsinom için risk faktörüdür. Bu çalışmada H. pylori’nin primer mide lenfoma ve mide kanserinde prognostik faktör olup olmadığı incelendi.Yöntemler: Primer mide lenfoma ve mide kanserli 255 hastanın rezeksiyon veya biyopsi materyalleri H. pylori açısından incelendi. Patoloji spesmenlerinde H. pylori varlığını değerlendirmek için hematoksilen ve eozin boyası kullanıldı.Bulgular: Primer mide lenfomalı 140 hastanın 34’ünde (%24,3) H. pylori saptanırken mide kanserli 115 hastanın 62’sinde (%53,9) H. pylori saptandı. H. pylori varlığı mide kanserli hastalarda, mide lenfomalardan daha sık görüldü (p<0.001). H. pylori pozitifliği, mide lenfoma içinde mukoza ilişkili lenfoid doku tip lenfomada (MALT) %53,5 oranında, diffüz büyük B hücreli lenfomadan farklı olarak %18,7 oranında görüldü (p<0,001). Primer mide lenfoma da H. pylori’nin varlığı hastalıksız sağkalım ve genel sağkalım açısından anlamlılık oluşturmuyordu (p=0,833, p= 0,503). Bununla beraber mide kanserli hastalarda da H. pylori varlığı ile hastalıksız sağkalım ve genel sağkalımda da anlamlılık oluşturmuyordu (p=0,392, p= 0,357). Sonuç: Çalışmamızda mide kanserli ve primer mide lenfoma arasında H. pylori varlığı bakımından anlamlı farklılık vardı. Ancak H. pylori varlığı, hem hastalıksız sağkalım hem de genel sağkalım açısından prognostik anlamlılık oluşturmuyordu

Anahtar Kelimeler

• H. pylori, Primer mide lenfoma, Mide kanser

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