BibTex RIS Cite

The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite

Year 2013, , 71 - 74, 01.06.2013
https://doi.org/10.5799/ahinjs.02.2013.02.0084

Abstract

Objective: Envenoming resulting from snakebites is a common devastating problem that is frequently seen in eastern and southeastern regions of Turkey. This aim of this study is to observe the changes of snake venom on serum copper (Cu), zinc (Zn), and magnesium (Mg) levels in patients with snakebite. Materials and Methods: Patients with snakebite and healthy individuals as control group were included in the study. Overall 10 ml venous blood sample was taken from each study individuals. Serum trace elements were measured using an atomic absorption spectrophotometer. Results: Forty patients with snakebite and 80 healthy individuals in the control group were included in the study. The mean age of the patients with snakebite was 40.1 &plusmn;12 years; of these, 18 were male (45%). The mean age of the 80 healthy individuals was 40.6 &plusmn;10 years; of these, 36 were male (45%). Serum Cu, Zn, and Mg levels of patients with snakebite were 75.8 &plusmn;20.9, 86.9 &plusmn;25.2, and 1201 &plusmn;562 &mu;g/dL, respectively. Serum Cu, Zn, and Mg levels of healthy individuals were 57.6 &plusmn;17.2, 55.8 &plusmn;12.4, and 1454 &plusmn;278 &mu;g/dL, respectively. There were statistically significant increas&shy;ing in serum Cu and Zn levels (p<0.001), and decreasing in serum Mg levels (p=0.001) in patients with snakebite when compared to healthy individuals. Conclusion: Snake venom produces significant alterations on serum Cu, Zn, and Mg levels in patients with snakebite. Investigating of these changes caused by snake venom through further studies may provide novel developments in the treatment of patients with snakebite.

References

  • Frangides CY, Koulouras V, Kouni SN, et al. Snake venom poi- soning in Greece. Experiences with 147 cases. Eur J Intern Med 2006; 17:24-27.
  • Warrell DA. Snakebite. Lancet 2010; 375:77-88.
  • Mora J, Mora R, Lomonte B, Gutiérrez JM. Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hid- den aspect of envenomation.PLoS Negl Trop Dis 2008; 2 (10):e318.
  • Milne DB. Trace elements. In: Burtis CA, Ashhwood LE, eds. Tietz Textbook of Clinical Chemistry, 3rd edn. Philadelphia, W.B. Saunders, 1999:1029-1055.
  • Salgueiro MJ, Zubilaga M, Lysionek A, et al. Zinc as an es- sential micronutrient: a review. Nutr Res 2000;20:737-755.
  • Saris NEL, Mervaala E, Karppanen H, Khawaja JA, Lewens- tam A. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 2000; 294:1-26.
  • De Romana DL, Olivares M, Uauy R, Araya M. Risk and ben- efit of copper in light of new insights of copper homeostasis. J Trace Elem Med Biol 2011; 25:3-13.
  • Masironi M. Trace elements and cardiovascular diseases. B World Health Organ 1969; 40:305-312.
  • Sullivan JF, Blotcky AJ, Jeton MM, Hahn HKJ, Burch RE. Serum levels of selenium, calcium, copper, magnesium, manganese and zinc in various human diseases. J Nutr 2008;12:1432-1437.
  • Pathak P, Kapil U. Role of trace elements zinc, copper and magnesium during pregnancy and its outcome. Indian J Pe- diatr 2004;71:1003-1005.
  • Swenson S, Markland FS. Snake venom fibrin(ogen)olytic enzymes. Toxicon 2005; 45:1021-1039.
  • Vignaud A, Hourde C, Torres S, et al. Functional, cellular and molecular aspects of skeletal muscle recovery after injury induced by snake venom from Notechis scutatus scutatus. Toxicon 2005;45:789-801.
  • Chang KP, Lai CS, Lin SD. Management of poisonous snake- bites in southern Taiwan. Kaohsiung J Med Sci 2007;23:511- 518.
  • Viegas-Crespo AM, Pavao ML, Paulo O, et al. Trace element status (Se, Cu, Zn) and serum lipid profile in Portuguese sub- jects of San Miguel Island from Azores’archipelago. J Trace Elem Med Biol 2000;14:1-5.
  • Painter PC, Cope JY, Smith JL. Reference information for the clinical laboratory. In: Burtis CA, Ashhwood LE, eds. Tietz Textbook of Clinical Chemistry, 3rd edn. Philadelphia, W.B. Saunders, 1999:1788-1846.
  • Hedera P, Fink JK, Bockensted PL, Brewer GJ. Myelopolineu- ropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin. Arch Neurol 2003;60:1303- 1306.
  • Elin RJ. Assessment of magnesium status. Clin Chem 1987; 33:1965-1970.

The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite

Year 2013, , 71 - 74, 01.06.2013
https://doi.org/10.5799/ahinjs.02.2013.02.0084

Abstract

Amaç: Yılan ısırıkları Türkiye’nin doğu ve güneydoğu bölgelerinde sık görülen önemli bir problemdir. Bu çalışmada yılan ısırığı vakalarında serum bakır (Cu), çinko (Zn) ve magnezyum (Mg) düzeylerindeki değişiklikler araştırıldı.Yöntemler: Çalışmaya 40 yılan ısırıklı hasta ile kontrol amaçlı 80 sağlıklı gönüllü alındı. Yaklaşık 10 ml venöz kan çalışmaya alınan her bir bireyden alındı. Serum eser element düzeyleri Atomik Absorbsiyon Spektormetre cihazı kullanılarak ölçüldü. Bulgular: Çalışmaya alınan 40 yılan ısırıklı hastanın yaş ortalaması 40,1 ± 12 yıl olup, 18’i (% 45) erkek idi. Sağlıklı 80 bireyin yaş ortalaması 40,6 ± 10 yıl olup, 36’sı (% 45) erkek idi. Yılan ısırıklı hastaların serum Cu, Zn, ve Mg düzeyleri sırasıyla 75,8 ± 20,9; 86,9 ± 25,2 ve 1201 ± 562 µg/dL bulundu. Sağlıklı gönüllülerin serum Cu, Zn, and Mg düzeyleri sırasıyla 57,6 ± 17,2; 55,8 ± 12,4 ve 1454 ± 278 µg/dL bulundu. İstatistiksel olarak sağlıklı gönüllüler ile karşılaştırıldığında, yılan ısırıklı hastaların serum Cu ve Zn düzeylerinde anlamlı bir artış (p<0.001) ve serum Mg düzeylerinde anlamlı bir düşüş (p=0,001) saptandı.Sonuç: Yılan zehiri, yılan ısırığı olan hastaların serum Cu, Zn ve Mg düzeyleri üzerinde anlamlı değişimler oluşturmaktadır. Yılan zehrinin serum eser element düzeylerinde oluşturduğu bu değişimlerin ileri düzey çalışmalarla araştırılması yılan ısırığı olan hastaların tedavisinde yeni gelişmeler sağlayabilir

References

  • Frangides CY, Koulouras V, Kouni SN, et al. Snake venom poi- soning in Greece. Experiences with 147 cases. Eur J Intern Med 2006; 17:24-27.
  • Warrell DA. Snakebite. Lancet 2010; 375:77-88.
  • Mora J, Mora R, Lomonte B, Gutiérrez JM. Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hid- den aspect of envenomation.PLoS Negl Trop Dis 2008; 2 (10):e318.
  • Milne DB. Trace elements. In: Burtis CA, Ashhwood LE, eds. Tietz Textbook of Clinical Chemistry, 3rd edn. Philadelphia, W.B. Saunders, 1999:1029-1055.
  • Salgueiro MJ, Zubilaga M, Lysionek A, et al. Zinc as an es- sential micronutrient: a review. Nutr Res 2000;20:737-755.
  • Saris NEL, Mervaala E, Karppanen H, Khawaja JA, Lewens- tam A. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 2000; 294:1-26.
  • De Romana DL, Olivares M, Uauy R, Araya M. Risk and ben- efit of copper in light of new insights of copper homeostasis. J Trace Elem Med Biol 2011; 25:3-13.
  • Masironi M. Trace elements and cardiovascular diseases. B World Health Organ 1969; 40:305-312.
  • Sullivan JF, Blotcky AJ, Jeton MM, Hahn HKJ, Burch RE. Serum levels of selenium, calcium, copper, magnesium, manganese and zinc in various human diseases. J Nutr 2008;12:1432-1437.
  • Pathak P, Kapil U. Role of trace elements zinc, copper and magnesium during pregnancy and its outcome. Indian J Pe- diatr 2004;71:1003-1005.
  • Swenson S, Markland FS. Snake venom fibrin(ogen)olytic enzymes. Toxicon 2005; 45:1021-1039.
  • Vignaud A, Hourde C, Torres S, et al. Functional, cellular and molecular aspects of skeletal muscle recovery after injury induced by snake venom from Notechis scutatus scutatus. Toxicon 2005;45:789-801.
  • Chang KP, Lai CS, Lin SD. Management of poisonous snake- bites in southern Taiwan. Kaohsiung J Med Sci 2007;23:511- 518.
  • Viegas-Crespo AM, Pavao ML, Paulo O, et al. Trace element status (Se, Cu, Zn) and serum lipid profile in Portuguese sub- jects of San Miguel Island from Azores’archipelago. J Trace Elem Med Biol 2000;14:1-5.
  • Painter PC, Cope JY, Smith JL. Reference information for the clinical laboratory. In: Burtis CA, Ashhwood LE, eds. Tietz Textbook of Clinical Chemistry, 3rd edn. Philadelphia, W.B. Saunders, 1999:1788-1846.
  • Hedera P, Fink JK, Bockensted PL, Brewer GJ. Myelopolineu- ropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin. Arch Neurol 2003;60:1303- 1306.
  • Elin RJ. Assessment of magnesium status. Clin Chem 1987; 33:1965-1970.
There are 17 citations in total.

Details

Primary Language English
Journal Section ART
Authors

Cemal Ustun This is me

İbrahim Tegin This is me

Mehmet Faruk Geyik This is me

Publication Date June 1, 2013
Published in Issue Year 2013

Cite

APA Ustun, C., Tegin, İ., & Geyik, M. F. (2013). The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite. Journal of Microbiology and Infectious Diseases, 3(02), 71-74. https://doi.org/10.5799/ahinjs.02.2013.02.0084
AMA Ustun C, Tegin İ, Geyik MF. The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite. J Microbil Infect Dis. June 2013;3(02):71-74. doi:10.5799/ahinjs.02.2013.02.0084
Chicago Ustun, Cemal, İbrahim Tegin, and Mehmet Faruk Geyik. “The Effects of Snake Venom on Serum Copper, Zinc and Magnesium Levels in Patients With Snake Bite”. Journal of Microbiology and Infectious Diseases 3, no. 02 (June 2013): 71-74. https://doi.org/10.5799/ahinjs.02.2013.02.0084.
EndNote Ustun C, Tegin İ, Geyik MF (June 1, 2013) The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite. Journal of Microbiology and Infectious Diseases 3 02 71–74.
IEEE C. Ustun, İ. Tegin, and M. F. Geyik, “The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite”, J Microbil Infect Dis, vol. 3, no. 02, pp. 71–74, 2013, doi: 10.5799/ahinjs.02.2013.02.0084.
ISNAD Ustun, Cemal et al. “The Effects of Snake Venom on Serum Copper, Zinc and Magnesium Levels in Patients With Snake Bite”. Journal of Microbiology and Infectious Diseases 3/02 (June 2013), 71-74. https://doi.org/10.5799/ahinjs.02.2013.02.0084.
JAMA Ustun C, Tegin İ, Geyik MF. The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite. J Microbil Infect Dis. 2013;3:71–74.
MLA Ustun, Cemal et al. “The Effects of Snake Venom on Serum Copper, Zinc and Magnesium Levels in Patients With Snake Bite”. Journal of Microbiology and Infectious Diseases, vol. 3, no. 02, 2013, pp. 71-74, doi:10.5799/ahinjs.02.2013.02.0084.
Vancouver Ustun C, Tegin İ, Geyik MF. The effects of snake venom on serum copper, zinc and magnesium levels in patients with snake bite. J Microbil Infect Dis. 2013;3(02):71-4.