Middle East Respiratory Syndrome: MERS

Year 2015, , 93 - 98, 16.07.2015

Emine Parlak

https://doi.org/10.5799/ahinjs.02.2015.02.0184

Cited By: 1

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging respiratory virus. It was first identified in Saudi Arabia in 2012. MERS-CoV infection is characterized by a spectrum of illness ranging from mild to acute and fulminant disease. The majority of patients present with fever, fever with chills/rigors, cough, shortness of breath, and dry cough. Cases of human-to-human transmission have been documented. There is currently no specific treatment and vaccination for MERS-CoV infection. Surveillance and infection-control measures are of vital importance to an ef­ficient public health response. J Microbiol Infect Dis 2015;5(2): 93-98

Key words: Coronavirus, Middle East Respiratory Syndrome, MERS-CoV polymerase-chain-reaction, respiratory symptoms

Keywords

Coronavirus, Middle East Respiratory Syndrome, MERS-CoV polymerase-chain-reaction, respiratory symptoms

References

• De Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the coronavirus
• study group. J Virol 2013;87:7790-7792.
• MacIntyre CR. The discrepant epidemiology of Middle East respiratory
• syndrome coronavirus (MERS-CoV). Environ Syst Decis 2014;34:383-390.
• Bermingham A, Chand MA, Brown CS, et al. Severe respiratory illness
• caused by a novel coronavirus, in a patient transferred to the United
• Kingdom from the Middle East, September 2012. Euro Surveill.
• ;17:20290.
• Announcement of the Coronavirus Study Group. Middle East Respiratory Syn 1 drome Coronavirus (MERS-CoV). J. Virol 2013;87:7790-7792.
• Raj VS, Osterhaus AD, Fouchier RM, et al. MERS: emergence of a
• novel human coronavirus. Curr Opin Virol 2014;5:58-62.
• Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel
• coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012;367:1814-1820.
• Al-Tawfiq JA, Assiri A, Memish ZA. Middle East respiratory syndrome
• novel corona (MERS-CoV) infection Epidemiology and outcome update.
• Saudi Med J 2013;34:991-994.
• World Health Organization. Global alert and response (GAR): andemic
• and epidemic diseases (http://www.who.int/csr/disease/en/)
• Guery B, Poissy J, el Mansouf L, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory syndrome coronavirus: A report of nosocomial transmission. Lancet
• ;381:2265-2272.
• Breban R, Riou J, Fontanet A. Interhuman transmissibility of Middle
• East respiratory syndrome coronavirus: estimation of pandemic risk.
• Lancet 2013;382:694-699.
• Memish ZA, Zumla AI, Al-Hakeem RF, et al. Family cluster of Middle
• East respiratory syndrome coronavirus infections. N Engl J Med
• ;368:2487-2494.
• Health Protection Agency (HPA) UK Novel Coronavirus Investigation
• Team. Evidence of person-to-person transmission within a family
• cluster of novel coronavirus infections, United Kingdom, February
• Euro Surveill 2013;18:20427.
• Puzelli S, Azzi A, Santini MG, et al. Investigation of an imported case of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection
• in Florence, Italy, May to June 2013. Euro Surveill 2013;18:20564.
• Abroug F, Slim A, Ouanes-Besbes L. Family cluster of Middle East
• respiratory syndrome coronavirus infections, Tunisia, 2013 Emerg
• Infect Dis 2014;20:1527-1530.
• Assiri A, McGeer A, Perl TM, et al. Hospital outbreak of Middle East
• respiratory syndrome coronavirus. N Engl J Med 2013;369:407-416.
• Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of
• the Middle East respiratory syndrome coronavirus in Saudi Arabia: a
• descriptive genomic study. Lancet 2013;382:1993-2002.
• Omrani AS, Matin MA, Haddad Q, et al. A family cluster of Middle East
• respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case. Int J Infect Dis 2013;17:e668-
• e672.
• De Sousa R, Reusken C, Koopmans M. MERS coronavirus: Data
• gaps for laboratory preparedness. J Clin Virol 2014;59:4-11.
• Bauch CT, Oraby T. Assessing the pandemic potential of MERS-CoV.
• Lancet 2013;382:662-664.
• Drosten C, Seilmaier M, Corman VM, et al. Transmission of MERSCoronavirus in household contacts. N Engl J Med 2014;371:828-835.
• Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 2013;13:752-761.
• Memish ZA, Almasri M, Turkestani A, et al. Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program. Int J Infec Dis 2014;25:186-190.
• Eckerle I, Müller MA, Kallies S, et al. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J 2013;10:359.
• Memish ZA, Al-Tawfig JA, Makhdoom HQ, et al. Screening for Middle
• East respiratory syndrome coronavirus infection in hospital patients
• and their healthcare worker and family contacts: a prospective descriptive study. Clin Microbiol Infect 2014;20(5):469-474.
• http://who.int/csr/disease/coronavirus_infections/MERS_home
• Memish MA, Cotton M, Meyer B, et al. Human Infection with MERS
• Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013.
• Emerg Infect Dis 2014;20:1012-1015.
• Reusken CB, Lina PH, Pielaat A, et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis 2013;13:859-
• -
• Azhar EI, El-Kafrawy S A, Farraj S A, et al. Evidence for Camelto-Human Transmission of MERS Coronavirus. N Engl J Med 2014;370:2499-2505.
• Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of
• the Middle East respiratory syndrome coronavirus in Saudi Arabia: a
• descriptive genomic study. Lancet 2013;382:1993-2002.
• Corman V, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction.Euro Surveill 2012;17:20285.
• Hijawi B, Abdallat M, Sayaydeh A, et al. Novel coronavirus infections
• in Jordan, April 2012: epidemiological findings from a retrospective
• investigation. East Mediterr Health J. 2013;19:S12-18.
• Momattin H, Mohammed K, Zumla A, et al. Therapeutic Options for
• Middle East Respiratory Syndrome Coronavirus (MERS-CoV) - possible
• lessons from a systematic review of SARS-CoV therapy. Int J Infect Dis 2013;17:e792-e798.
• Balkhair A, Al Maamari K, Alawi FB. The struggle against MERS-CoV
• (The Novel Coronavirus). Oman Med J 2013;28:226-227.
• Wilde AH, Raj S, Oudshoorn D, et al. MERS-coronavirus replication
• induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment. J Gen Virol 2013;94:1749-1760.
• Omrani AS, Saad MM, Baig K, et al. Ribavirin and interferon alfa-2a
• for severe Middle East respiratory syndrome coronavirus infection:
• a retrospective cohort study. Lancet Infect Dis 2014;14:1090-1095.
• Pavli A, Tsiodras S, Maltezou HC. Middle East respiratory syndrome
• coronavirus (MERS-CoV): Prevention in travelers. Travel Med and
• Infect Dis 2014;12:602-608.