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Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo

Year 2015, , 147 - 150, 06.02.2016
https://doi.org/10.5799/ahinjs.02.2015.04.0195

Abstract

Objective: Brucellosis became a remarkable disease in Kosovo. But there is not a comprehensive epidemiological study about pidemiology and clinical course of this disease from Kosovo. The aim of our study is to present demographic and clinical data of patients with brucellosis at University Clinical Center of Kosovo.

Methods: A retrospective study was performed for the patients with brucellosis treated in our clinic during years 2011- 2012. The data about demography, history of the disease, clinical presentations, serological test, serum biochemistry and treatment were collected from hospital medical records. The diagnosis of brucellosis based on clinical and laboratory findings.

Results: This descriptive study included 47 patients, who 33 of them (70.2%) were males. The mean age was 37.9 ± 19.3 years. The route of transmission of the disease was known in 28 (59.5%) of them. Direct contact with livestock in 22 (46.8%) and ingestion of dairy products in six cases (12.7%) were reported as the transmission route. The majority of patients (27 patients, 57.4%) were from rural area. The main presenting symptoms were fatigue, fever and arthralgia. Osteoarticular manifestations were the common forms of localized disease. Regarding to the therapy, 45 (95.7%) of patients were treated with streptomycin and doxycycline for the first three weeks.

Conclusion: Human brucellosis is not a common in Kosovo but there is a potential risk. Osteoarticular symptoms were the most common presentation reasons. The most effective and preferred treatment regimen was Streptomycin plus Doxycycline for the first three weeks, and Doxycycline plus Rifampicin thereafter. J Microbiol Infect Dis 2015;5(4): 147-150

Key words: Brucellosis, fever, osteoarticular involvement

References

  • Muçaj S, Kabashi S, Gashi S, et al. Topographic expansion of Brucellosis in Kosovo. Materia Socio Medica 2009; Vol.21:No.2.
  • Shkodra B. Brucellosis in Gjilan Region during 2010-2012.The 1st International Conference on “Research and Education Challenges Towards the Future” (ICRAE 2013), 24-25May 2013.
  • Jackson R, Pite L, Kennard R, et al. Survey of the seroprevalence
  • of brucellosis in ruminants in Kosovo. Vet Rec 2004;12;154:747-751.
  • Yumuk Z, O’Callaghan D. Brucellosis in Turkey- an overview,Int J Infect Dis 2012; 16:e228-e235.
  • Buzgan T, Karahocagil MK, Irmak H, et al. Clinical manifestations
  • and complications in 1028 cases of brucellosis: a retrospective
  • evaluation and review of the literature. Int J Infect Dis. 2010; 14:e469-e478.
  • Sauret JM, Vilissova N. Human Brucellosis. JABFP. September-October 2002; vol.15;5.
  • Franco MP1, Mulder M, Gilman RH, et al. Human brucellosis.
  • Lancet Infect Dis 2007;7:775-786.
  • Mantur BG, Biradar MS, Bidri RC, et al. Protean clinical manifestations and diagnostic challenges of human brucellosis
  • in adults: 16 years’ experience in an endemic area. J Med Microbiol. 2006;55(Pt 7):897-903.
  • Ioannis G, Nikoleta MN, Maria E, et al. Presentation of childhood brucellosis in western Greece. Jpn J Infect Dis 2006;59:160-163.
  • Giannakopoulos I, Nikolakopoulou NM, Eliopoulou M, et al.
  • The new global map of human brucellosis. Jpn J Infect Dis. 2006;59:160-163.
  • Black TF. Brucellosis. In: Cohen J, Powderly WG editor. Infectious
  • diseases. 2nd ed. St. Louis: Mosby 2004;1665-1667.
  • Kassiri H, Amani H, Lotfi M. Epidemiological, laboratory, diagnostic and public health aspects of human brucellosis in western Iran. Asian Pac J Trop Biomed. 2013;3:589-594.
  • Guler S, Kokoglu OF, Ucmak H, et al. Human brucellosis in
  • Turkey: different clinical presentations. J Infect Dev Ctries. 2014 May 14;8:581-588.
  • Pappas G, Akritidis N, Bosilkovski M, et al. Brucellosis. N
  • Engl J Med 2005;352:2325-2336.
  • Ertek M, Yazgi H, Kadanali A, et al. Complications of Brucella
  • infection among adults: an 18-year retrospective evaluation. Turk J Med Sci 2006;36:377-381.
  • Solera J, Rodríguez-Zapata M, Geijo P, et al. Doxycyclinerifampin
  • versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. Antimicrob Agents Chemother 1995;39:2061-2067.

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Year 2015, , 147 - 150, 06.02.2016
https://doi.org/10.5799/ahinjs.02.2015.04.0195

Abstract

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References

  • Muçaj S, Kabashi S, Gashi S, et al. Topographic expansion of Brucellosis in Kosovo. Materia Socio Medica 2009; Vol.21:No.2.
  • Shkodra B. Brucellosis in Gjilan Region during 2010-2012.The 1st International Conference on “Research and Education Challenges Towards the Future” (ICRAE 2013), 24-25May 2013.
  • Jackson R, Pite L, Kennard R, et al. Survey of the seroprevalence
  • of brucellosis in ruminants in Kosovo. Vet Rec 2004;12;154:747-751.
  • Yumuk Z, O’Callaghan D. Brucellosis in Turkey- an overview,Int J Infect Dis 2012; 16:e228-e235.
  • Buzgan T, Karahocagil MK, Irmak H, et al. Clinical manifestations
  • and complications in 1028 cases of brucellosis: a retrospective
  • evaluation and review of the literature. Int J Infect Dis. 2010; 14:e469-e478.
  • Sauret JM, Vilissova N. Human Brucellosis. JABFP. September-October 2002; vol.15;5.
  • Franco MP1, Mulder M, Gilman RH, et al. Human brucellosis.
  • Lancet Infect Dis 2007;7:775-786.
  • Mantur BG, Biradar MS, Bidri RC, et al. Protean clinical manifestations and diagnostic challenges of human brucellosis
  • in adults: 16 years’ experience in an endemic area. J Med Microbiol. 2006;55(Pt 7):897-903.
  • Ioannis G, Nikoleta MN, Maria E, et al. Presentation of childhood brucellosis in western Greece. Jpn J Infect Dis 2006;59:160-163.
  • Giannakopoulos I, Nikolakopoulou NM, Eliopoulou M, et al.
  • The new global map of human brucellosis. Jpn J Infect Dis. 2006;59:160-163.
  • Black TF. Brucellosis. In: Cohen J, Powderly WG editor. Infectious
  • diseases. 2nd ed. St. Louis: Mosby 2004;1665-1667.
  • Kassiri H, Amani H, Lotfi M. Epidemiological, laboratory, diagnostic and public health aspects of human brucellosis in western Iran. Asian Pac J Trop Biomed. 2013;3:589-594.
  • Guler S, Kokoglu OF, Ucmak H, et al. Human brucellosis in
  • Turkey: different clinical presentations. J Infect Dev Ctries. 2014 May 14;8:581-588.
  • Pappas G, Akritidis N, Bosilkovski M, et al. Brucellosis. N
  • Engl J Med 2005;352:2325-2336.
  • Ertek M, Yazgi H, Kadanali A, et al. Complications of Brucella
  • infection among adults: an 18-year retrospective evaluation. Turk J Med Sci 2006;36:377-381.
  • Solera J, Rodríguez-Zapata M, Geijo P, et al. Doxycyclinerifampin
  • versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. Antimicrob Agents Chemother 1995;39:2061-2067.
There are 27 citations in total.

Details

Primary Language English
Journal Section Brief Report
Authors

Emine Buçaj This is me

Edmond Puca This is me

Sadie Namani This is me

Muharem Bajrami This is me

Valbon Krasniqi This is me

Lindita Berisha This is me

Xhevat Jakupi This is me

Bahrie Halili This is me

Dhimiter Kraja This is me

Publication Date February 6, 2016
Published in Issue Year 2015

Cite

APA Buçaj, E., Puca, E., Namani, S., Bajrami, M., et al. (2016). Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. Journal of Microbiology and Infectious Diseases, 5(4), 147-150. https://doi.org/10.5799/ahinjs.02.2015.04.0195
AMA Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D. Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. J Microbil Infect Dis. February 2016;5(4):147-150. doi:10.5799/ahinjs.02.2015.04.0195
Chicago Buçaj, Emine, Edmond Puca, Sadie Namani, Muharem Bajrami, Valbon Krasniqi, Lindita Berisha, Xhevat Jakupi, Bahrie Halili, and Dhimiter Kraja. “Brucellosis in Kosovo and Clinical Features of Brucellosis at University Clinical Center of Kosovo”. Journal of Microbiology and Infectious Diseases 5, no. 4 (February 2016): 147-50. https://doi.org/10.5799/ahinjs.02.2015.04.0195.
EndNote Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D (February 1, 2016) Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. Journal of Microbiology and Infectious Diseases 5 4 147–150.
IEEE E. Buçaj, “Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo”, J Microbil Infect Dis, vol. 5, no. 4, pp. 147–150, 2016, doi: 10.5799/ahinjs.02.2015.04.0195.
ISNAD Buçaj, Emine et al. “Brucellosis in Kosovo and Clinical Features of Brucellosis at University Clinical Center of Kosovo”. Journal of Microbiology and Infectious Diseases 5/4 (February 2016), 147-150. https://doi.org/10.5799/ahinjs.02.2015.04.0195.
JAMA Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D. Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. J Microbil Infect Dis. 2016;5:147–150.
MLA Buçaj, Emine et al. “Brucellosis in Kosovo and Clinical Features of Brucellosis at University Clinical Center of Kosovo”. Journal of Microbiology and Infectious Diseases, vol. 5, no. 4, 2016, pp. 147-50, doi:10.5799/ahinjs.02.2015.04.0195.
Vancouver Buçaj E, Puca E, Namani S, Bajrami M, Krasniqi V, Berisha L, Jakupi X, Halili B, Kraja D. Brucellosis in Kosovo and Clinical Features of Brucellosis at University clinical center of Kosovo. J Microbil Infect Dis. 2016;5(4):147-50.