Antimicrobial Efficacy of Silymarin and Silibinin Against Oral Microorganisms

Year 2017, , 139 - 143, 15.09.2017

Murali Iyangar Radhika Devaraj Ezhilarasan Prakasam Gopinath

https://doi.org/10.5799/jmid.367545

Cited By: 3

Abstract

Objective:
To evaluate the antimicrobial effect of silymarin and
silibinin, a plant derived flavonoid compounds against oral microorganisms that
are responsible for dental caries.

Methods:
In the current investigation, we analyzed the comparative
antibacterial and antifungal effect of silibinin and silymarin against clinical
cariogenic oral pathogens through evaluating their minimum inhibitory and
minimum bactericidal concentration. We used clinical isolates that are
responsible for dental caries and these include Candida albicans, Enterococcus faecalis, Lactobacillus acidophilus,
Staphylococcus aureus and Streptococcus
mutans to evaluate the anticariogenic potential of silymarin and silibinin.

Results:
In the present investigation, silymarin exhibit good
antimicrobial effect against most of the oral cariogenic microorganisms tested
when compared to silibinin. Interestingly, silymarin shows high sensitivity at
a concentration of <5 µg/ml against S.
mutans, L. acidophilus and C.
albicans. On the other hand, silibinin also have significant antimicrobial
effect against the oral pathogens. 

Conclusions: Silymarin and silibinin
can be used as appropriate drug candidates that control dental caries, endodontic
infections. 

Keywords

Silibinin, Silymarin, Oral infections, Oral pathogens

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