Erythrophagocytosis in Bone Marrow: A Clue to Pyrexia of Unknown Origin

Year 2018, , 73 - 75, 20.06.2018

Neha Garg Surabhi Raina Mrinalini Kotru Meera Sikka

https://doi.org/10.5799/jmid.434605

Abstract

ABSTRACT

Bone
marrow (BM) is usually done to investigate the patients for Pyrexia of Unknown
Origin (PUO). However, only 16.5 % of cases reveal any diagnostic information.
Increasing incidence of atypical presentations are seen in typhoid. Careful
examination of BM to pick up clues for diagnosis is important We report a case
of a 15 year old female who presented with fever since associated with altered
sensorium, gum bleeding and loose stools. Hematological findings revealed
pancytopenia with macrocytic anemia with erythrophagocytosis in BM aspirates. A
diagnosis of typhoid was made with a positive typhi dot IgM. The authors
present this case to highlight the importance of simple BM findings of
erythrophagocytosis and how awareness about this feature can point towards the
right diagnosis in the midst of atypical clinical and hematological features. J Microbiol Infect Dis 2018; 8(2):73-75.

Keywords

Bone marrow, typhoid fever, fever, macrophages, phagocytosis

References

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