Evaluation of Diagnostic Tests for Visceral Leishmaniasis in Iran: A Meta-Analysis

Year 2019, , 16 - 22, 15.03.2019

Azar Najafi Entezar Abbasi Somar Kourosh Sayehmiri Hamidreza Majidiani Asad Mirzaei

https://doi.org/10.5799/jmid.537150

Cited By: 1

Abstract

Objective: There exist various diagnostic tests to detect
visceral leishmaniasis, but the most efficient ones have not been demonstrated
yet. Herein, we evaluated the accuracy of these diagnostic tests in Iran.

Methodology: English and Persian database searching was done from
1993 to 2016. According to heterogeneity of the studies, estimations of the
study were pooled by random-effects model. Totally, twenty investigations were
eligible for current review with 2115 patients as pooled sample size.

Results:
The
overall pooled estimate of sensitivity and specificity for all diagnostic tests
were 0.92 ([95% CI = 0.90–0.95]) and 0.92 ([95% CI = 0.89–0.94]), respectively.
Also, the separate sensitivity and specificity of each test were as follow:
PCR: 1.00 ([95% CI = 0.99–1.01]) and 0.37 ([95% CI = 0.25–0.49]); DAT: 0.93
([95% CI = 0.89–0.96]) and 0.92 ([95% CI = 0.89–0.94]); ELISA: 0.78 ([95% CI =
0.47–1.09]) and 1.00 ([95% CI = 0.99–1.01]) as well as IFA: 0.50 ([95% CI =
0.29–0.72]) and 0.96 ([95% CI = 0.95–0.97]).

Conclusions: The specificity and sensitivity of PCR and DAT
as molecular and serological tests, respectively, are remarkable to detect
visceral leishmaniasis; hence, it is highly recommended to simultaneously
employ these diagnostic tests for this widespread infection. J Microbiol Infect Dis 2019; 9(1): 16-22

Keywords

Visceral Leishmaniasis, sensitivity, specificity, diagnostic tests, L. infantum, Iran

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