Case Report
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Year 2021, , 36 - 41, 15.03.2021
https://doi.org/10.5799/jmid.897222

Abstract

References

  • 1. Reploeg MD, Storch GA, Clifford DB. Bk virus: a clinical review. Clin Infect Dis an Off Publ Infect Dis Soc Am. 2001;33(2):191-202.
  • 2. Park SB, Kwak JH, Lee KT, et al. Polyoma Virus-Associated Nephropathy and Concurrent Cytomegalovirus Infection in the Kidney Transplant Recipients. Transplant Proc. 2006; 38(7):2059-2061.
  • 3. Cordero E, Casasola C, Ecarma R, Danguilan R. Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors. Transplant Proc. 2012;44(3):694-700.
  • 4. Hariharan S. BK virus nephritis after renal transplantation. Kidney Int. 2006;69(4):655-662.
  • 5. Yapa HMN, McLornan DP, Raj K, et al. Pneumonitis post-haematopoeitic stem cell transplant - cytopathology clinches diagnosis. J Clin Virol Off Publ Pan Am Soc Clin Virol. 2012;55(3):278-281.
  • 6. Yoshimura A, Tsuji T, Kawaji Y, Hirakawa Y, Uchiyama H, Hiraoka N. BK virus pneumonia following stem cell transplantation against diffuse large B-cell lymphoma. Respirol case reports. 2018;6(7): e00348.
  • 7. Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med. 2002;347(7):488-496.
  • 8. Galan A, Rauch CA, Otis CN. Fatal BK polyoma viral pneumonia associated with immunosuppression. Hum Pathol. 2005;36(9):1031-1034.
  • 9. Blazquez-Navarro A, Dang-Heine C, Wittenbrink N, et al. BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study. EBioMedicine. 2018; 34:113-121.
  • 10. Sandler ES, Aquino VM, Goss-Shohet E, Hinrichs S, Krisher K. BK papova virus pneumonia following hematopoietic stem cell transplantation. Bone Marrow Transplant. 1997;20(2):163-165.
  • 11. Toyoda M, Puliyanda DP, Amet N, et al. Co-infection of polyomavirus-BK and cytomegalovirus in renal transplant recipients. Transplantation. 2005;80(2):198-205.
  • 12. Akazawa Y, Terada Y, Yamane T, et al. Fatal BK virus pneumonia following stem cell transplantation. Transpl Infect Dis. 2012;14(6):E142-6.
  • 13. Zaman RA, Ettenger RB, Cheam H, Malekzadeh MH, Tsai EW. A novel treatment regimen for BK viremia. Transplantation. 2014;97(11):1166-1171.

BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy

Year 2021, , 36 - 41, 15.03.2021
https://doi.org/10.5799/jmid.897222

Abstract

BK virus (BKV) pneumonia is a rare entity especially seen in immunosuppressed patients, for which cidofovir is the used treatment option. We describe a case of a young female patient who presented for altered kidney function six months following kidney transplantation for focal segmental glomerulosclerosis and was found to have BKV nephritis. Her in-hospital stay was complicated by BKV pneumonia requiring mechanical ventilation, in addition to CMV colitis. She was treated with leflunomide/ciprofloxacin and ganciclovir for her pneumonia and colitis, respectively. The patient improved clinically except that her kidney function deteriorated. Leflunomide/ciprofloxacin combination may constitute an effective and safe alternative to cidofovir for the treatment of BKV pneumonia, in particular when cidofovir is not available. J Microbiol Infect Dis 2021; 11(1):36-41.

References

  • 1. Reploeg MD, Storch GA, Clifford DB. Bk virus: a clinical review. Clin Infect Dis an Off Publ Infect Dis Soc Am. 2001;33(2):191-202.
  • 2. Park SB, Kwak JH, Lee KT, et al. Polyoma Virus-Associated Nephropathy and Concurrent Cytomegalovirus Infection in the Kidney Transplant Recipients. Transplant Proc. 2006; 38(7):2059-2061.
  • 3. Cordero E, Casasola C, Ecarma R, Danguilan R. Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors. Transplant Proc. 2012;44(3):694-700.
  • 4. Hariharan S. BK virus nephritis after renal transplantation. Kidney Int. 2006;69(4):655-662.
  • 5. Yapa HMN, McLornan DP, Raj K, et al. Pneumonitis post-haematopoeitic stem cell transplant - cytopathology clinches diagnosis. J Clin Virol Off Publ Pan Am Soc Clin Virol. 2012;55(3):278-281.
  • 6. Yoshimura A, Tsuji T, Kawaji Y, Hirakawa Y, Uchiyama H, Hiraoka N. BK virus pneumonia following stem cell transplantation against diffuse large B-cell lymphoma. Respirol case reports. 2018;6(7): e00348.
  • 7. Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med. 2002;347(7):488-496.
  • 8. Galan A, Rauch CA, Otis CN. Fatal BK polyoma viral pneumonia associated with immunosuppression. Hum Pathol. 2005;36(9):1031-1034.
  • 9. Blazquez-Navarro A, Dang-Heine C, Wittenbrink N, et al. BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study. EBioMedicine. 2018; 34:113-121.
  • 10. Sandler ES, Aquino VM, Goss-Shohet E, Hinrichs S, Krisher K. BK papova virus pneumonia following hematopoietic stem cell transplantation. Bone Marrow Transplant. 1997;20(2):163-165.
  • 11. Toyoda M, Puliyanda DP, Amet N, et al. Co-infection of polyomavirus-BK and cytomegalovirus in renal transplant recipients. Transplantation. 2005;80(2):198-205.
  • 12. Akazawa Y, Terada Y, Yamane T, et al. Fatal BK virus pneumonia following stem cell transplantation. Transpl Infect Dis. 2012;14(6):E142-6.
  • 13. Zaman RA, Ettenger RB, Cheam H, Malekzadeh MH, Tsai EW. A novel treatment regimen for BK viremia. Transplantation. 2014;97(11):1166-1171.
There are 13 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Ali R. Chaitou This is me

Mouhamad Nasser This is me

Hussein Karnıb This is me

Amal Hamieh This is me

Publication Date March 15, 2021
Published in Issue Year 2021

Cite

APA Chaitou, A. R., Nasser, M., Karnıb, H., Hamieh, A. (2021). BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy. Journal of Microbiology and Infectious Diseases, 11(01), 36-41. https://doi.org/10.5799/jmid.897222
AMA Chaitou AR, Nasser M, Karnıb H, Hamieh A. BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy. J Microbil Infect Dis. March 2021;11(01):36-41. doi:10.5799/jmid.897222
Chicago Chaitou, Ali R., Mouhamad Nasser, Hussein Karnıb, and Amal Hamieh. “BK Virus Pneumonia With CMV Colitis in a Kidney Transplant Recipient: Successful Treatment With Non-Cidofovir Based Therapy”. Journal of Microbiology and Infectious Diseases 11, no. 01 (March 2021): 36-41. https://doi.org/10.5799/jmid.897222.
EndNote Chaitou AR, Nasser M, Karnıb H, Hamieh A (March 1, 2021) BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy. Journal of Microbiology and Infectious Diseases 11 01 36–41.
IEEE A. R. Chaitou, M. Nasser, H. Karnıb, and A. Hamieh, “BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy”, J Microbil Infect Dis, vol. 11, no. 01, pp. 36–41, 2021, doi: 10.5799/jmid.897222.
ISNAD Chaitou, Ali R. et al. “BK Virus Pneumonia With CMV Colitis in a Kidney Transplant Recipient: Successful Treatment With Non-Cidofovir Based Therapy”. Journal of Microbiology and Infectious Diseases 11/01 (March 2021), 36-41. https://doi.org/10.5799/jmid.897222.
JAMA Chaitou AR, Nasser M, Karnıb H, Hamieh A. BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy. J Microbil Infect Dis. 2021;11:36–41.
MLA Chaitou, Ali R. et al. “BK Virus Pneumonia With CMV Colitis in a Kidney Transplant Recipient: Successful Treatment With Non-Cidofovir Based Therapy”. Journal of Microbiology and Infectious Diseases, vol. 11, no. 01, 2021, pp. 36-41, doi:10.5799/jmid.897222.
Vancouver Chaitou AR, Nasser M, Karnıb H, Hamieh A. BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy. J Microbil Infect Dis. 2021;11(01):36-41.