Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta

Year 2017, Volume: 07 Issue: 01, 29 - 35, 01.03.2017

Mirari Prasadajudio

https://doi.org/10.5799/jmid.328842

Cited By: 1

Abstract

Objectives: Indonesia is known for high incidence of typhoid fever especially in children. This study aimed to observe
antibiotic susceptibility in circulating Salmonella typhi serotypes in children with typhoid.
Methods: A cross sectional study design was conducted. A total of 142 blood samples from children between 1-18
years old clinically diagnosed with suspected typhoid fever were recruited between January 2012 and July 2013 from
six health centers in Jakarta. Confirmed cases were retrieved based on S. typhi isolate finding in blood culture.
Antimicrobial susceptibility was investigated and PCR was used to detect S. typhi serotypes using fliB, fliC and aroC
genes.
Results: The prevalence of confirmed typhoid case based on isolate finding was 22 (15.5%). Twenty of S. typhi
isolates expressed fliC gene carrying H:d allele, the other two expressed j allele, while only two samples expressed
fliB, all showed no difference in pathogenicity and antimicrobial resistance.
Conclusions: Circulating serotypes found in typhoid children in Jakarta, Indonesia are still susceptible even to the
firstline antimicrobials. Thus, chloramphenicol, ampicillin and co-trimoxazole are still recommended. J Microbiol Infect
Dis 2017; 7(1): 29-35

Keywords

Salmonella typhi, child, serogroup, microbial sensitivity test

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