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Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta

Year 2017, Volume: 07 Issue: 01, 29 - 35, 01.03.2017
https://doi.org/10.5799/jmid.328842

Abstract

Objectives: Indonesia is known for high incidence of typhoid fever especially in children. This study aimed to observe
antibiotic susceptibility in circulating Salmonella typhi serotypes in children with typhoid.
Methods: A cross sectional study design was conducted. A total of 142 blood samples from children between 1-18
years old clinically diagnosed with suspected typhoid fever were recruited between January 2012 and July 2013 from
six health centers in Jakarta. Confirmed cases were retrieved based on S. typhi isolate finding in blood culture.
Antimicrobial susceptibility was investigated and PCR was used to detect S. typhi serotypes using fliB, fliC and aroC
genes.
Results: The prevalence of confirmed typhoid case based on isolate finding was 22 (15.5%). Twenty of S. typhi
isolates expressed fliC gene carrying H:d allele, the other two expressed j allele, while only two samples expressed
fliB, all showed no difference in pathogenicity and antimicrobial resistance.
Conclusions: Circulating serotypes found in typhoid children in Jakarta, Indonesia are still susceptible even to the
firstline antimicrobials. Thus, chloramphenicol, ampicillin and co-trimoxazole are still recommended. J Microbiol Infect
Dis 2017; 7(1): 29-35


References

  • 1. Crump JA, Luby SP, Mintz ED. The global burden of typhoid fever. Bull World Health Organ 2004;82:346-253.
  • 2. World Health Organization. Background document: The diagnosis, treatment and prevention of typhoid fever. Geneva: The Organization; 2003. http://www.who.int/rpc/TFGuideWHO.pdf
  • 3. Ochiai RL, Acosta CJ, Danovaro-Holliday MC, et al. A study of typhoid fever in five Asian countries: disease burden and implications for controls. Bull World Health Organ 2008; 86:260-268.
  • 4. Centers for Disease Control and Prevention Indonesia. Ministry of Health Republic of Indonesia ( 2007) Typhoid fever prevalence.
  • 5. Buckle GC, Walker CL, Black RE. Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. J Glob Health 2012; 2:010401.
  • 6. Parry CM, Threlfall EJ. Antimicrobial resistance in typhoidal and nontyphoidal salmonellae. Curr Opin Infect Dis. 2008; 21:531-538.
  • 7. Rowe B, Ward LR, Threlfall EJ. Multidrug-resistant Salmonella typhi: a worldwide epidemic. Clin Infect Dis 1997; 24 (Suppl 1):S106-9.
  • 8. Mirza SH, Beeching NJ, Hart CA. Multi-drug resistant typhoid: a global problem. J Med Microbiol 1996; 44:317-319.
  • 9. Hatta M, Ratnawati N. Enteric fever in endemic areas of Indonesia: an increasing problem of resistance. J Infect Dev Ctries 2008;2:279-282.
  • 10. Hatta M, Sultan AR, Pastoor R, Smits HL. New flagellin gene for Salmonella enterica serovar Typhi from the East Indonesian archipelago. Am J Trop Med Hyg 2011; 84:429-434.
  • 11. Moshitch S, Doll L, Rubinfeld BZ, et al. Mono- and bi-phasic Salmonella typhi: genetic homogeneity and distinguishing characteristics. Mol Microbiol 1992; 6:2589-2597.
  • 12. Grossman DA, Witham ND, Burr DH, et al. Flagellar serotypes of Salmonella typhi in Indonesia: relationships among motility, invasiveness, and clinical illness. J Infect Dis 1995; 171:212-216.
  • 13. Baker S, Holt K, van de Vosse E, Roumagnac P, et al. High-throughput genotyping of Salmonella enterica serovar Typhi allowing geographical assignment of haplotypes and pathotypes within an urban District of Jakarta, Indonesia. J Clin Microbiol 2008; 46:1741-1746.
  • 14. Le TA, Fabre L, Roumagnac P, Grimont PA, Scavizzi MR, Weill FX. Clonal expansion and microevolution of quinolone-resistant Salmonella enterica serotype typhi in Vietnam from 1996 to 2004. J Clin Microbiol 2007;45:3485-3492.
  • 15. Banoo S, Bell D, Bossuyt P, et al. Evaluation of diagnostic tests for infectious diseases: general principles. Natur Rev Microbiol 2006;4 (Suppl 9):S21-S31.
  • 16. Soenarto Y, Aman AT, Bakri A, et al. Burden of severe rotavirus diarrhea in indonesia. J Infect Dis. 2009;200 (Suppl 1):S188-S194.
  • 17. Dewan AM, Corner R, Hashizume M, Ongee ET. Typhoid Fever and its association with environmental factors in the Dhaka Metropolitan Area of Bangladesh: a spatial and time-series approach. PLoS Negl Trop Dis 2013; 7(1):e1998.
  • 18. Tam FC, Ling TK, Wong KT, Leung DT, Chan RC, Lim PL. The TUBEX test detects not only typhoidspecific antibodies but also soluble antigens and whole bacteria. J Med Microbiol 2008; 57:316-323.
  • 19. Clegg A, Passey M, Omena M, Karigifa K, Suve N. Re-evaluation of the Widal agglutination test in response to the changing pattern of typhoid fever in the highlands of Papua New Guinea. Acta Tropica 1994; 57:255-263.
  • 20. Gasem MH, Dolmans WM, Isbandrio BB, Wahyono H, Keuter M, Djokomoeljanto R. Culture of Salmonella typhi and Salmonella paratyphi from blood and bone marrow in suspected typhoid fever. Trop Geograph Med 1995; 47:164-167.
  • 21.Gonsalves WI, Cornish N, Moore M, Chen A, Varman M. Effects of volume and site of blood draw on blood culture results. J Clin Microbiol 2009; 47:3482-3485.
  • 22. Baker S, Hardy J, Sanderson KE, et al. A novel linear plasmid mediates flagellar variation in Salmonella typhi. PloS Pathogen 2007; 3:605-610.
  • 23. Moehario LH, Tjoa E, Kalay V, Abidin A. Antibiotic susceptibility patterns of Salmonella typhi in Jakarta and surounding areas. In: Kumar Y (Edt) Salmonella a diversified superbug. Rijeka: InTech 2012. p: 91-98.
Year 2017, Volume: 07 Issue: 01, 29 - 35, 01.03.2017
https://doi.org/10.5799/jmid.328842

Abstract

References

  • 1. Crump JA, Luby SP, Mintz ED. The global burden of typhoid fever. Bull World Health Organ 2004;82:346-253.
  • 2. World Health Organization. Background document: The diagnosis, treatment and prevention of typhoid fever. Geneva: The Organization; 2003. http://www.who.int/rpc/TFGuideWHO.pdf
  • 3. Ochiai RL, Acosta CJ, Danovaro-Holliday MC, et al. A study of typhoid fever in five Asian countries: disease burden and implications for controls. Bull World Health Organ 2008; 86:260-268.
  • 4. Centers for Disease Control and Prevention Indonesia. Ministry of Health Republic of Indonesia ( 2007) Typhoid fever prevalence.
  • 5. Buckle GC, Walker CL, Black RE. Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. J Glob Health 2012; 2:010401.
  • 6. Parry CM, Threlfall EJ. Antimicrobial resistance in typhoidal and nontyphoidal salmonellae. Curr Opin Infect Dis. 2008; 21:531-538.
  • 7. Rowe B, Ward LR, Threlfall EJ. Multidrug-resistant Salmonella typhi: a worldwide epidemic. Clin Infect Dis 1997; 24 (Suppl 1):S106-9.
  • 8. Mirza SH, Beeching NJ, Hart CA. Multi-drug resistant typhoid: a global problem. J Med Microbiol 1996; 44:317-319.
  • 9. Hatta M, Ratnawati N. Enteric fever in endemic areas of Indonesia: an increasing problem of resistance. J Infect Dev Ctries 2008;2:279-282.
  • 10. Hatta M, Sultan AR, Pastoor R, Smits HL. New flagellin gene for Salmonella enterica serovar Typhi from the East Indonesian archipelago. Am J Trop Med Hyg 2011; 84:429-434.
  • 11. Moshitch S, Doll L, Rubinfeld BZ, et al. Mono- and bi-phasic Salmonella typhi: genetic homogeneity and distinguishing characteristics. Mol Microbiol 1992; 6:2589-2597.
  • 12. Grossman DA, Witham ND, Burr DH, et al. Flagellar serotypes of Salmonella typhi in Indonesia: relationships among motility, invasiveness, and clinical illness. J Infect Dis 1995; 171:212-216.
  • 13. Baker S, Holt K, van de Vosse E, Roumagnac P, et al. High-throughput genotyping of Salmonella enterica serovar Typhi allowing geographical assignment of haplotypes and pathotypes within an urban District of Jakarta, Indonesia. J Clin Microbiol 2008; 46:1741-1746.
  • 14. Le TA, Fabre L, Roumagnac P, Grimont PA, Scavizzi MR, Weill FX. Clonal expansion and microevolution of quinolone-resistant Salmonella enterica serotype typhi in Vietnam from 1996 to 2004. J Clin Microbiol 2007;45:3485-3492.
  • 15. Banoo S, Bell D, Bossuyt P, et al. Evaluation of diagnostic tests for infectious diseases: general principles. Natur Rev Microbiol 2006;4 (Suppl 9):S21-S31.
  • 16. Soenarto Y, Aman AT, Bakri A, et al. Burden of severe rotavirus diarrhea in indonesia. J Infect Dis. 2009;200 (Suppl 1):S188-S194.
  • 17. Dewan AM, Corner R, Hashizume M, Ongee ET. Typhoid Fever and its association with environmental factors in the Dhaka Metropolitan Area of Bangladesh: a spatial and time-series approach. PLoS Negl Trop Dis 2013; 7(1):e1998.
  • 18. Tam FC, Ling TK, Wong KT, Leung DT, Chan RC, Lim PL. The TUBEX test detects not only typhoidspecific antibodies but also soluble antigens and whole bacteria. J Med Microbiol 2008; 57:316-323.
  • 19. Clegg A, Passey M, Omena M, Karigifa K, Suve N. Re-evaluation of the Widal agglutination test in response to the changing pattern of typhoid fever in the highlands of Papua New Guinea. Acta Tropica 1994; 57:255-263.
  • 20. Gasem MH, Dolmans WM, Isbandrio BB, Wahyono H, Keuter M, Djokomoeljanto R. Culture of Salmonella typhi and Salmonella paratyphi from blood and bone marrow in suspected typhoid fever. Trop Geograph Med 1995; 47:164-167.
  • 21.Gonsalves WI, Cornish N, Moore M, Chen A, Varman M. Effects of volume and site of blood draw on blood culture results. J Clin Microbiol 2009; 47:3482-3485.
  • 22. Baker S, Hardy J, Sanderson KE, et al. A novel linear plasmid mediates flagellar variation in Salmonella typhi. PloS Pathogen 2007; 3:605-610.
  • 23. Moehario LH, Tjoa E, Kalay V, Abidin A. Antibiotic susceptibility patterns of Salmonella typhi in Jakarta and surounding areas. In: Kumar Y (Edt) Salmonella a diversified superbug. Rijeka: InTech 2012. p: 91-98.
There are 23 citations in total.

Details

Subjects Health Care Administration
Journal Section ART
Authors

Mirari Prasadajudio This is me

Publication Date March 1, 2017
Published in Issue Year 2017 Volume: 07 Issue: 01

Cite

APA Prasadajudio, M. (2017). Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta. Journal of Microbiology and Infectious Diseases, 07(01), 29-35. https://doi.org/10.5799/jmid.328842
AMA Prasadajudio M. Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta. J Microbil Infect Dis. March 2017;07(01):29-35. doi:10.5799/jmid.328842
Chicago Prasadajudio, Mirari. “Antimicrobial Susceptibility Pattern in Children With Typhoid Fever and Serotype of Salmonella Typhi in Jakarta”. Journal of Microbiology and Infectious Diseases 07, no. 01 (March 2017): 29-35. https://doi.org/10.5799/jmid.328842.
EndNote Prasadajudio M (March 1, 2017) Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta. Journal of Microbiology and Infectious Diseases 07 01 29–35.
IEEE M. Prasadajudio, “Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta”, J Microbil Infect Dis, vol. 07, no. 01, pp. 29–35, 2017, doi: 10.5799/jmid.328842.
ISNAD Prasadajudio, Mirari. “Antimicrobial Susceptibility Pattern in Children With Typhoid Fever and Serotype of Salmonella Typhi in Jakarta”. Journal of Microbiology and Infectious Diseases 07/01 (March 2017), 29-35. https://doi.org/10.5799/jmid.328842.
JAMA Prasadajudio M. Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta. J Microbil Infect Dis. 2017;07:29–35.
MLA Prasadajudio, Mirari. “Antimicrobial Susceptibility Pattern in Children With Typhoid Fever and Serotype of Salmonella Typhi in Jakarta”. Journal of Microbiology and Infectious Diseases, vol. 07, no. 01, 2017, pp. 29-35, doi:10.5799/jmid.328842.
Vancouver Prasadajudio M. Antimicrobial susceptibility pattern in children with typhoid fever and serotype of Salmonella typhi in Jakarta. J Microbil Infect Dis. 2017;07(01):29-35.