Factors Associated with Treatment Failure among Smear Positive TB Patients in Khorasan-e-Razavi and Sistan-Baluchistan Provinces, Iran

Year 2016, Volume: 6 Issue: 4, 172 - 178, 01.12.2016

Hekmatollah Khoubfekr

https://doi.org/10.5799/jmid.328927

Abstract

Introduction: Tuberculosis (TB) treatment failure is one of the major problems of the health sector in developing countries.
Poor treatment of patients leads to drug resistance, relapse, death, and ultimately prevents TB control programs.
This study was conducted to determine the factors affecting tuberculosis treatment failure in Khorasan and Sistan- Balochistan
regions which have a high prevalence of TB.
Methods: In this case - control study 270 patients with tuberculosis (90 cases, 180 controls) were analyzed. New TB
patients registered with failure to treatment according to the national protocol between March 2008 - March 2012 were
chosen as cases and new TB patients with negative sputum smear in the same time frame were enrolled as control
group. Demographic data and clinical treatment outcomes were collected through interviews and file records. Multivariate
logistic regression analysis was used to determine the predictors of treatment failure in SPSS 19.
Results: Independent factors and predictors of failure treatment included illiteracy, a three plus positive sputum smear,
positive sputum smear at end of the second month, non-implementation of the Directly Observed Treatment Short
strategy by healthcare staff, history of addiction and history of diabetes.
Conclusion: Intervention programs for early detection and control of diabetes, drug control programs, giving priority to
providing DOTS by health care workers, more individual care and attention to patients with initial smear p + 3 or those
that remain sputum positive at the end of the second month or those who are less educated is necessary. J Microbiol
Infect Dis 2016;6(4): 172-178  

Keywords

Tuberculosis, Treatment failure, Iran

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