A Case of Meropenem Induced Cholestasis

Year 2016, Volume: 6 Issue: 4, 190 - 191, 01.12.2016

Büşra Canbaz

https://doi.org/10.5799/jmid.328938

Abstract

Meropenem is a broad-spectrum carbapenem antibiotic used for complicated hospital infections. Mild aminotransferase
elevations have been reported in meropenem recipients, but cholestasis is rare. A 70 year old man was admitted
for infected diabetic foot ulcer. ALP and GGT levels started increasing one week after the initiation of meropenem, with
normal ALT, AST and bilirubin levels. Meropenem induced intrahepatic cholestasis was suspected and meropenem was
discontinued, followed by normalization of liver enzymes.
Drug induced liver injury should be suspected in patients with unexplained liver enzyme elevations. J Microbiol Infect
Dis 2016;6(4): 190-191  

Keywords

Meropenem, drug induced, liver injury, cholestasis

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