Hemophagocytic Syndrome Associated with Herpes Virus 8 and Multicentric Castleman Diseases in A HIV-Negative Patient

Year 2017, Volume: 07 Issue: 04, 202 - 206, 01.12.2017

Arturo González Raya Eva Martín Salido Miguel Cantero Sánchez Gonzalo Callejón Martín María L. Hortas Nieto

https://doi.org/10.5799/jmid.369272

Abstract

The Hemophagocytic syndrome (HS) is a very rare
and aggressive disorder characterized by strong immunological activation of the
mononuclear phagocyte system sometimes triggered by viral infections such as Epstein-Barr
Virus. Castleman disease is a heterogeneous group of lymphoproliferative
disorders associated in some cases with the human immunodeficiency virus (HIV)
and human Herpes Virus 8 (HHV-8). The association of HHV-8, Multicentric
Castleman Disease (MCD) and Hemophagocytic Syndrome is extremely rare. There
are very few reported cases in literature, mostly in HIV positive elderly
patients with fatal prognosis.We report a case of Hemophagocytic syndrome,
HHV-8 and MCD on an HIV negative young adult. J Microbiol Infect Dis 2017; 7(4):202-206

Keywords

Hemophagocytic syndrome, Multicentric Castleman Disease, Herpes virus 8, HIV

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