Year 2019, Volume 09 , Issue 03, Pages 104 - 111 2019-09-15

Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan

Zakir Khan [1] , Naveed Ahmed [2] , Asim-ur- Rehman [3] , Faiz Ullah Khan [4] , Hazir Rahman [5]


ABSTRACT

Objectives: To investigate the utilization pattern of Surgical antibiotic prophylaxis (SAP) for the prevention of surgical infections in most common abdominal and orthopedic surgical procedures.

Methods: A prospective observational and non-intervention study was conducted at two teaching hospitals (PIMS and SIH) in Islamabad, Pakistan. Prescriptions records were reviewed to assess the utilization pattern of SAP during the nine-month duration. Data regarding most common surgical procedures, antimicrobial utilization, dose, route and administration timing of SAP were extracted for analysis. Observed practices were compared with standard treatment guidelines.

Results: Out of total 1512 surgical procedures about, 56.9% (n=860) of patients performed abdominal followed by 652 (43.1%) orthopedic surgical procedures. A total of 212 (14%) surgical procedures were completely correct in all steps. SAP were given in 1474 (97.5%) of surgical procedures. In 712 of the participants (48.3%) were given Ceftriaxone following by Cefazolin (n=247, 16.7%). Abdominal surgeries were majorly managed with Ceftriaxone (59%) while the orthopedic surgeries managed with Ceftriaxone (31.3%) and Cefazolin (30%). Appropriate choice of SAP was observed in (n=275; 18.6%) procedures and about half (n=719, 49%) received antibiotics within optimal timing. The appropriate choice/selection of SAP according to the guidelines was greater in orthopedic surgical procedures (n=212; 14.8%) than abdominal surgeries (n=63; 4.3%); p≤0.001. Compliance with respect to timing was significantly lower in an orthopedic surgical procedure (n=301) as compared to abdominal surgeries (n=418); p≤0.001. Similarly, a statistically significant difference observed between PIMS and SIH with respect to SAP practices; p≤0.001.

Conclusions: Inappropriate choice, the timing of administration and combination of SAP were observed in the current study. J Microbiol Infect Dis 2019; 9(3):104-111.

Surgery, perioperative, antibiotic, prophylaxis, hospital
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Primary Language en
Journal Section Research Article
Authors

Author: Zakir Khan (Primary Author)
Institution: Department of Pharmacy Quaid-i-Azam University Islamabad, Pakistan
Country: Pakistan


Author: Naveed Ahmed

Author: Asim-ur- Rehman

Author: Faiz Ullah Khan

Author: Hazir Rahman

Dates

Publication Date : September 15, 2019

Bibtex @research article { jmid614180, journal = {Journal of Microbiology and Infectious Diseases}, issn = {2146-3158}, eissn = {2146-9369}, address = {}, publisher = {Sağlık Araştırmaları Derneği}, year = {2019}, volume = {09}, pages = {104 - 111}, doi = {10.5799/jmid.614180}, title = {Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan}, key = {cite}, author = {Khan, Zakir and Ahmed, Naveed and Rehman, Asim-ur- and Khan, Faiz Ullah and Rahman, Hazir} }
APA Khan, Z , Ahmed, N , Rehman, A , Khan, F , Rahman, H . (2019). Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan. Journal of Microbiology and Infectious Diseases , 09 (03) , 104-111 . DOI: 10.5799/jmid.614180
MLA Khan, Z , Ahmed, N , Rehman, A , Khan, F , Rahman, H . "Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan". Journal of Microbiology and Infectious Diseases 09 (2019 ): 104-111 <https://dergipark.org.tr/en/pub/jmid/issue/48485/614180>
Chicago Khan, Z , Ahmed, N , Rehman, A , Khan, F , Rahman, H . "Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan". Journal of Microbiology and Infectious Diseases 09 (2019 ): 104-111
RIS TY - JOUR T1 - Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan AU - Zakir Khan , Naveed Ahmed , Asim-ur- Rehman , Faiz Ullah Khan , Hazir Rahman Y1 - 2019 PY - 2019 N1 - doi: 10.5799/jmid.614180 DO - 10.5799/jmid.614180 T2 - Journal of Microbiology and Infectious Diseases JF - Journal JO - JOR SP - 104 EP - 111 VL - 09 IS - 03 SN - 2146-3158-2146-9369 M3 - doi: 10.5799/jmid.614180 UR - https://doi.org/10.5799/jmid.614180 Y2 - 2019 ER -
EndNote %0 Journal of Microbiology and Infectious Diseases Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan %A Zakir Khan , Naveed Ahmed , Asim-ur- Rehman , Faiz Ullah Khan , Hazir Rahman %T Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan %D 2019 %J Journal of Microbiology and Infectious Diseases %P 2146-3158-2146-9369 %V 09 %N 03 %R doi: 10.5799/jmid.614180 %U 10.5799/jmid.614180
ISNAD Khan, Zakir , Ahmed, Naveed , Rehman, Asim-ur- , Khan, Faiz Ullah , Rahman, Hazir . "Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan". Journal of Microbiology and Infectious Diseases 09 / 03 (September 2019): 104-111 . https://doi.org/10.5799/jmid.614180
AMA Khan Z , Ahmed N , Rehman A , Khan F , Rahman H . Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan. J Microbil Infect Dis. 2019; 09(03): 104-111.
Vancouver Khan Z , Ahmed N , Rehman A , Khan F , Rahman H . Pattern of Surgical Antibiotic Prophylaxis for Surgical Site Infections in at two Teaching Hospitals, Islamabad, Pakistan. Journal of Microbiology and Infectious Diseases. 2019; 09(03): 111-104.