In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates

Year 2019, Volume: 09 Issue: 03, 112 - 115, 15.09.2019

Estelle Caine Ozlem Koyuncu Ozyurt Gozde Ongut Kubra Kasaroglu Emre Yıldız Dilara Ogunc Filiz Gunseren Dilek Colak Ozge Turhan Betil Ozhak

https://doi.org/10.5799/jmid.614195

Abstract

Objectives: Urinary tract infections (UTIs) remain one of the most
common infections for antibiotic prescription. Increased resistance to
antibiotics currently used to treat these infections may lead to significant
problems. Extended spectrum beta-lactamase (ESBL) production in organisms
causing UTIs are often responsible for the increase in resistance. The aim of
this study was to investigate the in vitro antimicrobial susceptibility of ESBL
producing community acquired urinary E.
coli isolates to Ceftazidime/Avibactam (CAZ/AVI) and other antimicrobial
agents using disk diffusion method.

Methods:
Between 2016 and 2017, a total of 100 ESBL producing E. coli urine isolates were collected from outpatients who had no
history of hospitalization in the last three months in Akdeniz University
Hospital. All isolates were tested for in vitro susceptibility to the CAZ/AVI
and other antimicrobial agents using disk diffusion method. Results: No CAZ/AVI and carbapenem
resistance were observed. Resistance rates to other antimicrobial agents were
as follows: ampicillin 100%, amoxicillin/clavulanate 85%, cefotaxime 98%,
ceftazidime 89%, cefepime 82%, gentamicin 41%, ciprofloxacin 65%, levofloxacin
39%, fosfomycin 3%, nitrofurantoin 2%, trimethoprim/sulfamethoxazole 72% and
Piperacillin/Tazobactam 41%.

Conclusions: Our results showed that ceftazidime / avibactam,
carbapenems, nitrofurantoin and fosfomycin may be among the first line
treatment options in the empirical therapy. In selected patients, CAZ/AVI could
be an option for the treatment of UTI caused by ESBL producing E.coli which may reduce the use of
carbapenems. J Microbiol Infect Dis
2019; 9(2):112-115.

Keywords

Ceftazidime-avibactam, ESBL, Urinary tract infections, in vitro

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