Year 2019, Volume 09 , Issue 03, Pages 112 - 115 2019-09-15

In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates

Estelle Caine [1] , Ozlem Koyuncu Ozyurt [2] , Gozde Ongut [3] , Kubra Kasaroglu [4] , Emre Yıldız [5] , Dilara Ogunc [6] , Filiz Gunseren [7] , Dilek Colak [8] , Ozge Turhan [9] , Betil Ozhak [10]


Objectives: Urinary tract infections (UTIs) remain one of the most common infections for antibiotic prescription. Increased resistance to antibiotics currently used to treat these infections may lead to significant problems. Extended spectrum beta-lactamase (ESBL) production in organisms causing UTIs are often responsible for the increase in resistance. The aim of this study was to investigate the in vitro antimicrobial susceptibility of ESBL producing community acquired urinary E. coli isolates to Ceftazidime/Avibactam (CAZ/AVI) and other antimicrobial agents using disk diffusion method.

Methods: Between 2016 and 2017, a total of 100 ESBL producing E. coli urine isolates were collected from outpatients who had no history of hospitalization in the last three months in Akdeniz University Hospital. All isolates were tested for in vitro susceptibility to the CAZ/AVI and other antimicrobial agents using disk diffusion method. Results: No CAZ/AVI and carbapenem resistance were observed. Resistance rates to other antimicrobial agents were as follows: ampicillin 100%, amoxicillin/clavulanate 85%, cefotaxime 98%, ceftazidime 89%, cefepime 82%, gentamicin 41%, ciprofloxacin 65%, levofloxacin 39%, fosfomycin 3%, nitrofurantoin 2%, trimethoprim/sulfamethoxazole 72% and Piperacillin/Tazobactam 41%.

Conclusions: Our results showed that ceftazidime / avibactam, carbapenems, nitrofurantoin and fosfomycin may be among the first line treatment options in the empirical therapy. In selected patients, CAZ/AVI could be an option for the treatment of UTI caused by ESBL producing E.coli which may reduce the use of carbapenems. J Microbiol Infect Dis 2019; 9(2):112-115.

Ceftazidime-avibactam, ESBL, Urinary tract infections, in vitro
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Primary Language en
Journal Section Research Article
Authors

Author: Estelle Caine
Country: United Kingdom


Author: Ozlem Koyuncu Ozyurt

Author: Gozde Ongut

Author: Kubra Kasaroglu

Author: Emre Yıldız

Author: Dilara Ogunc (Primary Author)
Institution: Akdeniz University, Faculty of Medicine, Department of Medical Microbiology, Antalya,
Country: Turkey


Author: Filiz Gunseren

Author: Dilek Colak

Author: Ozge Turhan

Author: Betil Ozhak

Dates

Publication Date : September 15, 2019

Bibtex @research article { jmid614195, journal = {Journal of Microbiology and Infectious Diseases}, issn = {2146-3158}, eissn = {2146-9369}, address = {}, publisher = {Sağlık Araştırmaları Derneği}, year = {2019}, volume = {09}, pages = {112 - 115}, doi = {10.5799/jmid.614195}, title = {In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates}, key = {cite}, author = {Caine, Estelle and Koyuncu Ozyurt, Ozlem and Ongut, Gozde and Kasaroglu, Kubra and Yıldız, Emre and Ogunc, Dilara and Gunseren, Filiz and Colak, Dilek and Turhan, Ozge and Ozhak, Betil} }
APA Caine, E , Koyuncu Ozyurt, O , Ongut, G , Kasaroglu, K , Yıldız, E , Ogunc, D , Gunseren, F , Colak, D , Turhan, O , Ozhak, B . (2019). In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. Journal of Microbiology and Infectious Diseases , 09 (03) , 112-115 . DOI: 10.5799/jmid.614195
MLA Caine, E , Koyuncu Ozyurt, O , Ongut, G , Kasaroglu, K , Yıldız, E , Ogunc, D , Gunseren, F , Colak, D , Turhan, O , Ozhak, B . "In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates". Journal of Microbiology and Infectious Diseases 09 (2019 ): 112-115 <https://dergipark.org.tr/en/pub/jmid/issue/48485/614195>
Chicago Caine, E , Koyuncu Ozyurt, O , Ongut, G , Kasaroglu, K , Yıldız, E , Ogunc, D , Gunseren, F , Colak, D , Turhan, O , Ozhak, B . "In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates". Journal of Microbiology and Infectious Diseases 09 (2019 ): 112-115
RIS TY - JOUR T1 - In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates AU - Estelle Caine , Ozlem Koyuncu Ozyurt , Gozde Ongut , Kubra Kasaroglu , Emre Yıldız , Dilara Ogunc , Filiz Gunseren , Dilek Colak , Ozge Turhan , Betil Ozhak Y1 - 2019 PY - 2019 N1 - doi: 10.5799/jmid.614195 DO - 10.5799/jmid.614195 T2 - Journal of Microbiology and Infectious Diseases JF - Journal JO - JOR SP - 112 EP - 115 VL - 09 IS - 03 SN - 2146-3158-2146-9369 M3 - doi: 10.5799/jmid.614195 UR - https://doi.org/10.5799/jmid.614195 Y2 - 2019 ER -
EndNote %0 Journal of Microbiology and Infectious Diseases In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates %A Estelle Caine , Ozlem Koyuncu Ozyurt , Gozde Ongut , Kubra Kasaroglu , Emre Yıldız , Dilara Ogunc , Filiz Gunseren , Dilek Colak , Ozge Turhan , Betil Ozhak %T In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates %D 2019 %J Journal of Microbiology and Infectious Diseases %P 2146-3158-2146-9369 %V 09 %N 03 %R doi: 10.5799/jmid.614195 %U 10.5799/jmid.614195
ISNAD Caine, Estelle , Koyuncu Ozyurt, Ozlem , Ongut, Gozde , Kasaroglu, Kubra , Yıldız, Emre , Ogunc, Dilara , Gunseren, Filiz , Colak, Dilek , Turhan, Ozge , Ozhak, Betil . "In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates". Journal of Microbiology and Infectious Diseases 09 / 03 (September 2019): 112-115 . https://doi.org/10.5799/jmid.614195
AMA Caine E , Koyuncu Ozyurt O , Ongut G , Kasaroglu K , Yıldız E , Ogunc D , Gunseren F , Colak D , Turhan O , Ozhak B . In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. J Microbil Infect Dis. 2019; 09(03): 112-115.
Vancouver Caine E , Koyuncu Ozyurt O , Ongut G , Kasaroglu K , Yıldız E , Ogunc D , Gunseren F , Colak D , Turhan O , Ozhak B . In Vitro Activities of Ceftazidime-Avibactam and Comparator Antimicrobial Agents Tested against ESBL Producing Urinary E. coli Isolates. Journal of Microbiology and Infectious Diseases. 2019; 09(03): 115-112.