DRESS Syndrome- Uncommon Drug Reaction with Common Disease Treatment: A Case Report

Year 2020, Volume: 10 Issue: 04, 225 - 229, 15.12.2020

B Saroj Kumar Prusty Majed Abdulbasit Momin Yugvaveer K Goud Kiran Kumar Ramineni Safina Perveen

https://doi.org/10.5799/jmid.839481

Abstract

Drug Reaction with Eosinophilia and Systemic symptoms (DRESS syndrome), is a severe adverse reaction associated with diverse collection of drugs, characterized by severe mucocutaneous rash, eosinophilia, fever, lymphadenopathy and extensive systemic involvement. We report a case of a 21-year-old female who developed clinical manifestations of fever, maculopapular rash, lymphadenopathy, eosinophilia and systemic symptoms after taking antitubercular medication for pulmonary tuberculosis, with subsequent development of acute liver failure with encephalopathy and coagulopathy. She was managed successfully with withdrawal of the offending medication and supportive care in intensive care unit. This case highlights the importance of consideration of antitubercular medication related drug reaction even with delayed onset of symptoms. J Microbiol Infect Dis 2020; 10(4): 225-229.

Keywords

Anti-tubercular treatment, DRESS syndrome,, Eosinophilia, Management

References

• 1. Cacoub P, Musette P, Descamps V et al. The DRESS syndrome: a literature review. Am J Med 2011;124: 588-97.
• 2. Tas S, Simonart T. Drug rash with eosinophilia and systemic symptoms (DRESS syndrome). Acta Clin Belg 1999; 54:197-200.
• 3. Bocquet H, Bagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). Semin Cutan Med Surg 1996; 15: 250-7.
• 4. Kardaun SH, Sidoroff A, Valeyrie-Allanore L et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 2007; 156:609-11.
• 5. Walsh SA, Creamer D. Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking. ClinExp Dermatol 2011;36:6–11.
• 6. De A, Rajagopalan M, Sarda A, Das S, Biswas P. Drug reaction with eosinophilia and systemic symptoms: An update and review of recent literature. Indian J Dermatol 2018; 63:30-40
• 7. Kömür S, Ulu A, Kurtaran B, İnal AS, Taşova Y, Aksu HS.Telaprevir-related DRESS syndrome complicating hepatitis C treatment. J Microbio Infect Dis 2015;5(01):36-7.
• 8. Sultan SJ, Sameem F, Ashraf M. Drug reaction with eosinophilia and systemic symptoms: manifestations, treatment, and outcome in 17 patients.Int J Dermatol 2015;54(5):537-42.
• 9. Shaughnessy K, Bouchard S, Mohr M, Herre J, Salkey K. Minocycline-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with persistent myocarditis. J Am Acad Dermatol 2010; 62: 315-318.
• 10. Palmero D, Castagnino J, Musella RM, Mosca C, González Montaner P, de Casado GC. Difficult clinical management of anti-tuberculosis DRESS syndrome. Int J Tuberc Lung Dis 2013; 17:76-8.
• 11. Ichai P, Laurent-Bellue A, Saliba F, et al. Acute liver failure/injury related to drug reaction with eosinophilia and systemic symptoms: outcomes and prognostic factors. Transplantation 2017; 101(8): 1830-7.