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Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2

Year 2022, Volume: 12 Issue: 01, 38 - 51, 15.03.2022
https://doi.org/10.5799/jmid.1086226

Abstract

ABSTRACT
The emergence of numerous variants of SARS-CoV-2 has caused massive setbacks and prolonged the COVID-19 pandemic. Some of the variants are still under investigation, while some have become a reason of grave concern. One such variant is B.1.617.2, known as the Delta variant, which was first detected in India. A comprehensive analysis and comparison of this particular variant have been done to the original Wuhan strain, and the possible reasons behind rapid mutation have also been discussed.
A comprehensive literature search was done to summarize the information on the variants of SARS-CoV-2 and the reasons behind their mutation, with a significant focus on the B.1.617.2 variant. Data were collected from various online sources such as PubMed, Google Scholar, MEDLINE, Worldometer, WHO, CDC, and GISAID. In addition, 3D structures of spike proteins were obtained from Protein Data Bank (PDB).
The data shows that the spike protein of the B.1.617.2 strain is highly mutated and has accumulated eight amino acid changes. Besides spike protein, changes in non-structural proteins (nsP2, nsP3, nsP4, nsP12, and nsP15), other structural proteins (nucleocapsid and membrane protein), and accessory proteins (ns3, ns7a) have been observed as well. Furthermore, in almost all the variants of SARS-CoV-2, D614G mutation occurs, suggesting its role in increased infectivity and transmission.
New variants are continuously emerging on which we have no control. Spike mutations are more favored and essential in the evolution of new variants because it increases the transmissibility and infectivity of the virus. Therefore, to maximally protect public health, knowledge of different variants is essential. J Microbiol Infect Dis 2022; 12(1):38-51.

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Year 2022, Volume: 12 Issue: 01, 38 - 51, 15.03.2022
https://doi.org/10.5799/jmid.1086226

Abstract

References

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  • 24. Shen X, Tang H, McDanal C, Wagh K, Fischer W, Theiler J, Yoon H, Li D, Haynes BF, Sanders KO, Gnanakaran S. SARS-CoV-2 variant B. 1.1. 7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines. Cell host & microbe. 2021; 29(4):529-539. doi:10.1101/2021.01.27.428516
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  • 27. Planas D, Bruel T, Grzelak L, et al. Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies. Nat Med. 2021;27(5):917-924. doi:10.1038/s41591-021-01318-5
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  • 32. Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern. World Health Organisation.2021. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern (Accessed on 29 November 2021)
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  • 42. Tegally H, Wilkinson E, Giovanetti M, et al. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature. 2021;592(7854):438-443. doi:10.1038/s41586-021-03402-9
  • 43. Cele S, Gazy I, Jackson L, et al. Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma. Nature. 2021;593(7857):142-146. doi:10.1038/s41586-021-03471-w
  • 44. Estimates of severity and transmissibility of novel South Africa SARS-CoV-2 variant 501Y.V2. GitHub 2021. Available: https://cmmid.github.io/topics/covid19/reports/sa-novel-variant/2021_01_11_Transmissibility_and_severity_of_501Y_V2_in_SA. (Accessed May 25, 2021).
  • 45. Davies NG, Abbott S, Barnard RC, et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science. 2021;372(6538). doi:10.1126/science.abg3055
  • 46. Davies NG, Jarvis CI, CMMID COVID-19 Working Group, et al. Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7. Nature. 2021;593(7858):270-274. doi:10.1038/s41586-021-03426-1
  • 47. CoVsurver Analysis of the sequences. GISAID. Available: https://www.gisaid.org/. (Accessed Nov 29, 2021).
There are 47 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Review
Authors

Mohd Fardeen Husain Shahanshah This is me

Saloni Jain This is me

Bhawna Sharma This is me

Ananya Grewall This is me

Shalini Swami This is me

Publication Date March 15, 2022
Published in Issue Year 2022 Volume: 12 Issue: 01

Cite

APA Shahanshah, M. F. H., Jain, S., Sharma, B., Grewall, A., et al. (2022). Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2. Journal of Microbiology and Infectious Diseases, 12(01), 38-51. https://doi.org/10.5799/jmid.1086226
AMA Shahanshah MFH, Jain S, Sharma B, Grewall A, Swami S. Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2. J Microbil Infect Dis. March 2022;12(01):38-51. doi:10.5799/jmid.1086226
Chicago Shahanshah, Mohd Fardeen Husain, Saloni Jain, Bhawna Sharma, Ananya Grewall, and Shalini Swami. “Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2”. Journal of Microbiology and Infectious Diseases 12, no. 01 (March 2022): 38-51. https://doi.org/10.5799/jmid.1086226.
EndNote Shahanshah MFH, Jain S, Sharma B, Grewall A, Swami S (March 1, 2022) Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2. Journal of Microbiology and Infectious Diseases 12 01 38–51.
IEEE M. F. H. Shahanshah, S. Jain, B. Sharma, A. Grewall, and S. Swami, “Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2”, J Microbil Infect Dis, vol. 12, no. 01, pp. 38–51, 2022, doi: 10.5799/jmid.1086226.
ISNAD Shahanshah, Mohd Fardeen Husain et al. “Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2”. Journal of Microbiology and Infectious Diseases 12/01 (March 2022), 38-51. https://doi.org/10.5799/jmid.1086226.
JAMA Shahanshah MFH, Jain S, Sharma B, Grewall A, Swami S. Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2. J Microbil Infect Dis. 2022;12:38–51.
MLA Shahanshah, Mohd Fardeen Husain et al. “Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2”. Journal of Microbiology and Infectious Diseases, vol. 12, no. 01, 2022, pp. 38-51, doi:10.5799/jmid.1086226.
Vancouver Shahanshah MFH, Jain S, Sharma B, Grewall A, Swami S. Comparative Analysis of B.1.617.2 (Delta) Variant of SARS-CoV-2. J Microbil Infect Dis. 2022;12(01):38-51.