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A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications

Year 2014, Volume: 4 Issue: 5, 54 - 57, 01.06.2014
https://doi.org/10.5799/ahinjs.02.2014.S1.0142

Abstract

Hantaviruses are enveloped tri-segmented negative-stranded RNA viruses. Infection from these viruses is growing in last decades. They are causative agent for two types of diseases: a) Hemorrhagic fever with renal syndrome (HFRS), mostly observed in Eurasia and b) Hantavirus cardiopulmonary syndrome (HPS), mostly observed in American continent. There are several Hantaviruses known to infect humans, and their main hosts are rodents. HFRS is caused from Hantaan, Dobrava, Saaremaa, Seoul and Puumala virus. The main factor, which determines the severity of Hantavirus infection, is the degree of increased permeability of infected endothelium, and the most common clinical findings in those patients are fever, headache, abdominal pains, backache, myalgia and nausea or/and vomiting. There are already numerous publications with regards to the involvement of two major systems such as renal and pulmonary in patients with HFRS. In this paper we would try to make a short review about the involvement of other organs and systems of our body in those patients. Extrarenal manifestations of Hantavirus infection include: acute ocular impairment with visual function, acute myopia, central nervous system (CNS) complications, cardiovascular impairment with myocarditis, gastrointestinal hemorrhages, but liver and pancreas may be also affected.

References

  • Muranyi W, Bahr U, Zeier M, van der Woude FJ. Hantavirus Infection. J Am Soc Nephrol 2005;16:3669-3679.
  • Vaheri A, Henttonen H, Voutilainen L, et al. Hantavirus infec- tions in Europe and their impact on public health. Rev. Med. Virol 2013;23:35-49.
  • Hautala N, Kauma H, Vapalahti O, et al. Prospective study on ocular findings in acute Puumala hantavirus infection in hos- pitalised patients. Br J Ophthalmol 2011; 95:559-562.
  • Puca E, Pilaca A, Pipero P, et al. Hemorrhagic Fever with Renal Syndrome Complicated by Orchitis. Virol. Sin 2011;26:284- 288
  • Zeier M, Handermann M, Bahr U, et al. New ecological as- pects of Hantavirus infection: A change of a paradigm and a challenge of prevention-A review. Virus Genes 2005;30:157- 180.
  • Plyusnin A. Genetics of Hantaviruses: Implications to taxono- my. Arch Virol 2002;147:665-682.
  • Hautala T, Sironen T, Vapalahti O, et al. Hypophyseal Hemor- rhage and Panhypopituitarism during Puumala Virus Infec- tion: Magnetic Resonance Imaging and Detection of Viral Antigen in the Hypophysis. Clin Infec Dis 2002;35:96-101.
  • Kanerva M, Paakkala A, Mustonen J, et al. Pulmonary involve- ment in nephropathia epidemica: radiological findings and their clinical correlations. Clin Nephrol 1996;46:369-378.
  • Hautala T, Hautala N, Mähönen SM, et al. Young male patients are at elevated risk of developing serious central nervous system complications during acute Puumala hantavirus in- fection BMC Infectious Diseases 2011;11:217-221.
  • Mähönen SM, Sironen T, Vapalahti O, et al. Puumala virus RNA in cerebrospinal fluid in a patient with uncomplicated nephropathia epidemica. J Clin Virol 2007;40:248-251.
  • Bui-Mansfield LT, Torrington KG, Kim T. Acute pancreatitis in patients with hemorrhagic fever with renal syndrome. Mil Med 2001;166:167-170.
  • Kang E S, Lee S, Kim W, et al. Acute pancreatitis associated with haemorrhagic fever with renal syndrome. Nephrology 2005;10:421-425.
  • Puca E, Pilaca A, Pipero P, et al. Hemorrhagic Fever with Renal Syndrome Associated with Acute Pancreatitis. Virol. Sin 2012;27:214-217.
  • Vapalahti K, Paunio M, Brummer- Korvenkontio M, et al. Puumala virus infections in Finland: increased occupa- tional risk for farmers. American Journal of Epidemiology 1999;149:1142-1151.
  • Kim BN, Choi BD. Hemorrhagic Fever with Renal Syndrome Complicated with Pregnancy: A Case Report. The Korean Journal of Internal Medicine 2006;21:150-153.
  • Avsic-Zupanc T, Petrovec M, Furlan P, et al. Hemorrhagic fe- ver with renal syndrome in the Dolenjska region of Slovenia- a 10-year survey. Clin Infect Dis 1999;28:860-865.
  • Roig IL, Musher DM, Tweardy DJ. Severe Pulmonary In- volvement in a Case Attributed to Domestically Acquired Seoul Hantavirus in the United States Clinical Infectious Dis- eases 2012;54:91-94.

A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications

Year 2014, Volume: 4 Issue: 5, 54 - 57, 01.06.2014
https://doi.org/10.5799/ahinjs.02.2014.S1.0142

Abstract

Hantaviruslar zarflı üç seğmentli negatif sarmallı RNA virüslerindendir. Hantavirüslerden kaynaklanan enfeksiyonlar son dekadlarda artış gösterdi. İki farklı klinik tabloya neden olurlar: a) Renal sendromlu hemorajik ateş (HFRS), hemen tüm vakalar Avrasya’da gözlenir, b) Hantavirus kardiyopulmoner sendromu (HPS), hemen tüm vakalar Amerika kıtasında görülmektedir.İnsanları enfekte ettiği bilinen bir çok Hantavirus vardır ve ana konakları rodentlerdir. HFRS Hantaan, Dobrava, Saaremaa, Seoul ve Puumala virus türlerinden kaynaklanır. Hantavirüs enfeksiyonlarının şiddetini belirleyen ana faktörlerin başında enfekte endoteldeki artmış permeabilite gelmektedir. En yaygın klinik belirtiler ateş, başağrısı, karın ağrısı, başağrısı, sırtağrısı, myalji ve bulantı/kusmadır. HFRS’li hastalarda iki majör sistem olarak böbrek ve pulmoner sistemin etkilendiğine dair çok sayıda çalışma mevcuttur. Bu makalede ise HFRS’li hastalarda diğer sistem ve organların tutulumuna dair kısa bir derleme sunmak istiyoruz. Hantavirus infeksiyonunun ekstra-renal manifestasyonları olarak görme fonksiyonunda akut bozukluk, akut myopi, SSS komplikasyonları, myokardit şeklinde kardiyovasküler bozukluklar, gastrointestinal hemorajiler ile karaciğer ve pankreas organlarının etkilenmesi sayılabilir

References

  • Muranyi W, Bahr U, Zeier M, van der Woude FJ. Hantavirus Infection. J Am Soc Nephrol 2005;16:3669-3679.
  • Vaheri A, Henttonen H, Voutilainen L, et al. Hantavirus infec- tions in Europe and their impact on public health. Rev. Med. Virol 2013;23:35-49.
  • Hautala N, Kauma H, Vapalahti O, et al. Prospective study on ocular findings in acute Puumala hantavirus infection in hos- pitalised patients. Br J Ophthalmol 2011; 95:559-562.
  • Puca E, Pilaca A, Pipero P, et al. Hemorrhagic Fever with Renal Syndrome Complicated by Orchitis. Virol. Sin 2011;26:284- 288
  • Zeier M, Handermann M, Bahr U, et al. New ecological as- pects of Hantavirus infection: A change of a paradigm and a challenge of prevention-A review. Virus Genes 2005;30:157- 180.
  • Plyusnin A. Genetics of Hantaviruses: Implications to taxono- my. Arch Virol 2002;147:665-682.
  • Hautala T, Sironen T, Vapalahti O, et al. Hypophyseal Hemor- rhage and Panhypopituitarism during Puumala Virus Infec- tion: Magnetic Resonance Imaging and Detection of Viral Antigen in the Hypophysis. Clin Infec Dis 2002;35:96-101.
  • Kanerva M, Paakkala A, Mustonen J, et al. Pulmonary involve- ment in nephropathia epidemica: radiological findings and their clinical correlations. Clin Nephrol 1996;46:369-378.
  • Hautala T, Hautala N, Mähönen SM, et al. Young male patients are at elevated risk of developing serious central nervous system complications during acute Puumala hantavirus in- fection BMC Infectious Diseases 2011;11:217-221.
  • Mähönen SM, Sironen T, Vapalahti O, et al. Puumala virus RNA in cerebrospinal fluid in a patient with uncomplicated nephropathia epidemica. J Clin Virol 2007;40:248-251.
  • Bui-Mansfield LT, Torrington KG, Kim T. Acute pancreatitis in patients with hemorrhagic fever with renal syndrome. Mil Med 2001;166:167-170.
  • Kang E S, Lee S, Kim W, et al. Acute pancreatitis associated with haemorrhagic fever with renal syndrome. Nephrology 2005;10:421-425.
  • Puca E, Pilaca A, Pipero P, et al. Hemorrhagic Fever with Renal Syndrome Associated with Acute Pancreatitis. Virol. Sin 2012;27:214-217.
  • Vapalahti K, Paunio M, Brummer- Korvenkontio M, et al. Puumala virus infections in Finland: increased occupa- tional risk for farmers. American Journal of Epidemiology 1999;149:1142-1151.
  • Kim BN, Choi BD. Hemorrhagic Fever with Renal Syndrome Complicated with Pregnancy: A Case Report. The Korean Journal of Internal Medicine 2006;21:150-153.
  • Avsic-Zupanc T, Petrovec M, Furlan P, et al. Hemorrhagic fe- ver with renal syndrome in the Dolenjska region of Slovenia- a 10-year survey. Clin Infect Dis 1999;28:860-865.
  • Roig IL, Musher DM, Tweardy DJ. Severe Pulmonary In- volvement in a Case Attributed to Domestically Acquired Seoul Hantavirus in the United States Clinical Infectious Dis- eases 2012;54:91-94.
There are 17 citations in total.

Details

Primary Language English
Journal Section Review
Authors

Edmond Puca This is me

Arben Pilaca This is me

Pellumb Pipero This is me

Tritan Kalo This is me

Gentian Stroni This is me

Elda Qyra This is me

Entela Y Puca This is me

Dhimiter Kraja This is me

Publication Date June 1, 2014
Published in Issue Year 2014 Volume: 4 Issue: 5

Cite

APA Puca, E., Pilaca, A., Pipero, P., Kalo, T., et al. (2014). A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications. Journal of Microbiology and Infectious Diseases, 4(5), 54-57. https://doi.org/10.5799/ahinjs.02.2014.S1.0142
AMA Puca E, Pilaca A, Pipero P, Kalo T, Stroni G, Qyra E, Puca EY, Kraja D. A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications. J Microbil Infect Dis. June 2014;4(5):54-57. doi:10.5799/ahinjs.02.2014.S1.0142
Chicago Puca, Edmond, Arben Pilaca, Pellumb Pipero, Tritan Kalo, Gentian Stroni, Elda Qyra, Entela Y Puca, and Dhimiter Kraja. “A Short Review of Hemorrhagic Fever With Renal Syndrome and it'S Extrarenal Complications”. Journal of Microbiology and Infectious Diseases 4, no. 5 (June 2014): 54-57. https://doi.org/10.5799/ahinjs.02.2014.S1.0142.
EndNote Puca E, Pilaca A, Pipero P, Kalo T, Stroni G, Qyra E, Puca EY, Kraja D (June 1, 2014) A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications. Journal of Microbiology and Infectious Diseases 4 5 54–57.
IEEE E. Puca, A. Pilaca, P. Pipero, T. Kalo, G. Stroni, E. Qyra, E. Y. Puca, and D. Kraja, “A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications”, J Microbil Infect Dis, vol. 4, no. 5, pp. 54–57, 2014, doi: 10.5799/ahinjs.02.2014.S1.0142.
ISNAD Puca, Edmond et al. “A Short Review of Hemorrhagic Fever With Renal Syndrome and it'S Extrarenal Complications”. Journal of Microbiology and Infectious Diseases 4/5 (June 2014), 54-57. https://doi.org/10.5799/ahinjs.02.2014.S1.0142.
JAMA Puca E, Pilaca A, Pipero P, Kalo T, Stroni G, Qyra E, Puca EY, Kraja D. A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications. J Microbil Infect Dis. 2014;4:54–57.
MLA Puca, Edmond et al. “A Short Review of Hemorrhagic Fever With Renal Syndrome and it'S Extrarenal Complications”. Journal of Microbiology and Infectious Diseases, vol. 4, no. 5, 2014, pp. 54-57, doi:10.5799/ahinjs.02.2014.S1.0142.
Vancouver Puca E, Pilaca A, Pipero P, Kalo T, Stroni G, Qyra E, Puca EY, Kraja D. A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications. J Microbil Infect Dis. 2014;4(5):54-7.