Comparison of resistance in isolates of Enterococcus faecalis and Enterococcus faecium

Year 2011, Volume: 1 Issue: 01, 10 - 13, 01.03.2011

Fırat Zafer Mengeloğlu Derya Çakır Hüseyin Agah Terzi

https://doi.org/10.5799/ahinjs.02.2011.01.0003

Cited By: 1

Abstract

Objectives: Enterococci are Gram positive cocci causing hospital- and community-acquired infections even though they are found in normal flora and they have low-virulence. Their most common species detected as the causative agent are Enterococcus faecalis and Enterococcus faecium. This study aimed to evaluate the differences between the antibiotic susceptibilities of the isolates of these two species isolated from various clinical specimens. Materials and methods: In this study, 68 enterococci strains (40 E.faecalis and 28 E.faecium) isolated from the specimens sent to the clinical microbiology laboratory of Zonguldak Karaelmas Practice and Research Hospital in 2007-2008 were evaluated. Identification at species level and the susceptibilities were performed by using MicroScan WalkAway system (Dade Behring, USA). Results: No resistance to glycopeptides were detected among these isolates. High rates of resistance to ciprofloxacin, rifampicin and erytromycin were observed. Resistance rates to penicillin, ampicillin, ciprofloxacin, rifampicin, erytromycin and high-level gentamicin and streptomycin in E.faecium isolates were found statistically higher than the rates of E.faecalis group (p<0.05). Conclusions: As concordant with the literature, this study observed that E.faecium isolates were significantly more resistant. In enterococcal infections, performing the identification at the species level and determining the antibiotic susceptibility will be helpful in managing of the treatment.

Keywords

-

Comparison of resistance in isolates of Enterococcus faecalis and Enterococcus faecium

Abstract

Keywords

-

References

• Soysal A. Enterokoklar. J Pediatr Inf 2007; 1: 39-42.
• Ünlü M, Vardar Ünlü G, Bakıcı MZ, Şahin A. Resistance of Enterococcus faecalis and Enterococcus faecium strains isolated from clinical samples to various antibiotics. İnfek Derg 2002; 16: 471-475.
• Hoşgör M, Çavuşoğlu C, Tünger A, Özinel MA. High-level aminoglycozide resistance in enterococci. İnfek Derg 1997; 11: 7-9.
• Shepard BD, Gilmore MS. Antibiotic resistant enterococci: the mechanisms and dynamics of drug introduction and resistance. Microb Infect 2002; 4: 215-224.
• Mert Dinç B, Aykut Arca E, Yağcı S, Karabiber N. In-vitro antibiotic susceptibility of Enterococcus faecalis and Enterococcus faecium strains isolated from various clinical samples. Türkiye Hijyen ve Deneysel Biyoloji Dergisi 2009; 66: 117-121.
• Çaylan R, Üstünakın M, Kadımov V, Aydın K, Köksal İ. Antibiotic susceptibilities of Enterococcus strains isolated from stool and clinical samples. Türk Mikrobiyol Cem Derg 2004; 34: 24-28.
• Meriç M, Rüzgar M, Gündeş S, Willke A. Enterococcus species isolated from hospitalized patients and their antibiotic resistance patterns. ANKEM Derg 2004; 18: 141-144.
• Gazi H, Kurutepe S, Sürücüoğlu S, Ecemiş T, Özbakkaloğlu B. Antimicrobial resistance in nosocomial Enterococcus faecalis and Enterococcus faecium strains. ANKEM Derg 2004; 18: 49-52.
• Kaçmaz B, Akça G, Çağlar K, Sultan N. Antimicrobial susceptibility of enterococci. ANKEM Derg 2003; 17: 28-32.
• Karadenizli A, Kolaylı F. Enterococcus species and their antibiotic susceptibilities isolated in Kocaeli University Medical Faculty. Türk Mikrobiyol Cem Derg 2002; 32: 212-5.
• Moaddab SR, Töreci K. Species level identification and investigation of resistance to vancomycin and some other antibiotics in Enterococcus strains. Türk Mikrobiyol Cem Derg 2000; 30:77-84.
• Öztürk R, Eroğlu C, Köksal F, Mert A, Aygün G. Antibiotic resistance and high-level gentamicin resistance in enterococci. ANKEM Derg 1995;9: 351-354.
• Ulusoy S, Hoşgör M, Özkan F, Özinel M, Tokbaş A. Investigation of antibiotic resistance of Enterococcus faecalis and Enterococcus faecium. ANKEM Derg 1995; 9: 12-16.
• Çınar T, Leblebicioğlu H, Sünbül M, Eroğlu C, Esen Ş, Günaydın M. Determination of high-level gentamicin and streptomycin resistance in enterococci. Flora 1999; 4:114-119.
• Gülsoy Ö, Kocazeybek B, Arıtürk S. Investigation of the susceptibility to various antibiotics and high level aminoglycosides resistance in enterococci isolated from surgical intensive care unit. Ankem Derg 2002; 16:96-99.
• Akıncı E, Balık İ, Tekeli E. Antimicrobial susceptibility of Enterococcus species collected from clinical specimens. Flora 1999; 4: 40-45.
• Schouten MA, Voss A. Hoogkamp-Korstanje JAA. The European VRE Study Group. Antimicrobial susceptibility patterns of enterococci causing infections in Europe, Antimicrob Agents Chemother 1999; 43: 2542-2546.
• Simonsen GS, Smabrekke L,Monnet DL et al. Prevalence of resistance to ampicillin, gentamicin and vancomycin in Enterococcus faecalis ve Enterococcus faecium isolates from clinical specimens and use of antimicrobials in five Nordic hospitals, J Antimicrob Chemother 2003; 51: 323-331.
• Doern GV, Jones RN, Pfaller MA, Kugler K, Beach ML. Bacterial pathogens isolated from patients with skin and soft tissue infections: frequencies of occurence and antimicrobial susceptibility patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997), DiagnMicrobiol Infect Dis 1999; 34: 65-72.