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Middle East Respiratory Syndrome: MERS

Year 2015, Volume: 5 Issue: 2, 93 - 98, 16.07.2015

Emine Parlak

https://doi.org/10.5799/ahinjs.02.2015.02.0184
Cited By: 1

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging respiratory virus. It was first identified in Saudi Arabia in 2012. MERS-CoV infection is characterized by a spectrum of illness ranging from mild to acute and fulminant disease. The majority of patients present with fever, fever with chills/rigors, cough, shortness of breath, and dry cough. Cases of human-to-human transmission have been documented. There is currently no specific treatment and vaccination for MERS-CoV infection. Surveillance and infection-control measures are of vital importance to an ef­ficient public health response. J Microbiol Infect Dis 2015;5(2): 93-98

Key words: Coronavirus, Middle East Respiratory Syndrome, MERS-CoV polymerase-chain-reaction, respiratory symptoms

Keywords

Coronavirus Middle East Respiratory Syndrome MERS-CoV polymerase-chain-reaction respiratory symptoms

References

  • De Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the coronavirus
  • study group. J Virol 2013;87:7790-7792.
  • MacIntyre CR. The discrepant epidemiology of Middle East respiratory
  • syndrome coronavirus (MERS-CoV). Environ Syst Decis 2014;34:383-390.
  • Bermingham A, Chand MA, Brown CS, et al. Severe respiratory illness
  • caused by a novel coronavirus, in a patient transferred to the United
  • Kingdom from the Middle East, September 2012. Euro Surveill.
  • ;17:20290.
  • Announcement of the Coronavirus Study Group. Middle East Respiratory Syn 1 drome Coronavirus (MERS-CoV). J. Virol 2013;87:7790-7792.
  • Raj VS, Osterhaus AD, Fouchier RM, et al. MERS: emergence of a
  • novel human coronavirus. Curr Opin Virol 2014;5:58-62.
  • Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel
  • coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012;367:1814-1820.
  • Al-Tawfiq JA, Assiri A, Memish ZA. Middle East respiratory syndrome
  • novel corona (MERS-CoV) infection Epidemiology and outcome update.
  • Saudi Med J 2013;34:991-994.
  • World Health Organization. Global alert and response (GAR): andemic
  • and epidemic diseases (http://www.who.int/csr/disease/en/)
  • Guery B, Poissy J, el Mansouf L, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory syndrome coronavirus: A report of nosocomial transmission. Lancet
  • ;381:2265-2272.
  • Breban R, Riou J, Fontanet A. Interhuman transmissibility of Middle
  • East respiratory syndrome coronavirus: estimation of pandemic risk.
  • Lancet 2013;382:694-699.
  • Memish ZA, Zumla AI, Al-Hakeem RF, et al. Family cluster of Middle
  • East respiratory syndrome coronavirus infections. N Engl J Med
  • ;368:2487-2494.
  • Health Protection Agency (HPA) UK Novel Coronavirus Investigation
  • Team. Evidence of person-to-person transmission within a family
  • cluster of novel coronavirus infections, United Kingdom, February
  • Euro Surveill 2013;18:20427.
  • Puzelli S, Azzi A, Santini MG, et al. Investigation of an imported case of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection
  • in Florence, Italy, May to June 2013. Euro Surveill 2013;18:20564.
  • Abroug F, Slim A, Ouanes-Besbes L. Family cluster of Middle East
  • respiratory syndrome coronavirus infections, Tunisia, 2013 Emerg
  • Infect Dis 2014;20:1527-1530.
  • Assiri A, McGeer A, Perl TM, et al. Hospital outbreak of Middle East
  • respiratory syndrome coronavirus. N Engl J Med 2013;369:407-416.
  • Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of
  • the Middle East respiratory syndrome coronavirus in Saudi Arabia: a
  • descriptive genomic study. Lancet 2013;382:1993-2002.
  • Omrani AS, Matin MA, Haddad Q, et al. A family cluster of Middle East
  • respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case. Int J Infect Dis 2013;17:e668-
  • e672.
  • De Sousa R, Reusken C, Koopmans M. MERS coronavirus: Data
  • gaps for laboratory preparedness. J Clin Virol 2014;59:4-11.
  • Bauch CT, Oraby T. Assessing the pandemic potential of MERS-CoV.
  • Lancet 2013;382:662-664.
  • Drosten C, Seilmaier M, Corman VM, et al. Transmission of MERSCoronavirus in household contacts. N Engl J Med 2014;371:828-835.
  • Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 2013;13:752-761.
  • Memish ZA, Almasri M, Turkestani A, et al. Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program. Int J Infec Dis 2014;25:186-190.
  • Eckerle I, Müller MA, Kallies S, et al. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J 2013;10:359.
  • Memish ZA, Al-Tawfig JA, Makhdoom HQ, et al. Screening for Middle
  • East respiratory syndrome coronavirus infection in hospital patients
  • and their healthcare worker and family contacts: a prospective descriptive study. Clin Microbiol Infect 2014;20(5):469-474.
  • http://who.int/csr/disease/coronavirus_infections/MERS_home
  • Memish MA, Cotton M, Meyer B, et al. Human Infection with MERS
  • Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013.
  • Emerg Infect Dis 2014;20:1012-1015.
  • Reusken CB, Lina PH, Pielaat A, et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis 2013;13:859-
  • -
  • Azhar EI, El-Kafrawy S A, Farraj S A, et al. Evidence for Camelto-Human Transmission of MERS Coronavirus. N Engl J Med 2014;370:2499-2505.
  • Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of
  • the Middle East respiratory syndrome coronavirus in Saudi Arabia: a
  • descriptive genomic study. Lancet 2013;382:1993-2002.
  • Corman V, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction.Euro Surveill 2012;17:20285.
  • Hijawi B, Abdallat M, Sayaydeh A, et al. Novel coronavirus infections
  • in Jordan, April 2012: epidemiological findings from a retrospective
  • investigation. East Mediterr Health J. 2013;19:S12-18.
  • Momattin H, Mohammed K, Zumla A, et al. Therapeutic Options for
  • Middle East Respiratory Syndrome Coronavirus (MERS-CoV) - possible
  • lessons from a systematic review of SARS-CoV therapy. Int J Infect Dis 2013;17:e792-e798.
  • Balkhair A, Al Maamari K, Alawi FB. The struggle against MERS-CoV
  • (The Novel Coronavirus). Oman Med J 2013;28:226-227.
  • Wilde AH, Raj S, Oudshoorn D, et al. MERS-coronavirus replication
  • induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment. J Gen Virol 2013;94:1749-1760.
  • Omrani AS, Saad MM, Baig K, et al. Ribavirin and interferon alfa-2a
  • for severe Middle East respiratory syndrome coronavirus infection:
  • a retrospective cohort study. Lancet Infect Dis 2014;14:1090-1095.
  • Pavli A, Tsiodras S, Maltezou HC. Middle East respiratory syndrome
  • coronavirus (MERS-CoV): Prevention in travelers. Travel Med and
  • Infect Dis 2014;12:602-608.

-

Year 2015, Volume: 5 Issue: 2, 93 - 98, 16.07.2015

Emine Parlak

https://doi.org/10.5799/ahinjs.02.2015.02.0184
Cited By: 1

Abstract

Orta Doğu Solunum Sendromu coronovirüsü (MERS-CoV) yeni ortaya çıkan bir solunum virüsüdür. Bu virus ilk olarak 2012 yılında Suudi Arabistan’da tanımlanmıştır. Orta Doğu solunum sendromu koronavirüs enfeksiyonu akut hafif bir hastalık ile fulminan hastalık arasında değişen bir klinik spektrum ile karakterizedir. Hastaların çoğunluğunda ateş, ateş ile titreme, öksürük, nefes darlığı ve kuru öksürük bildirilmiştir. İnsandan insana bulaşan vakalar belgelenmiştir. MERSCoV enfeksiyonu için günümüzde özel bir tedavi ve aşılama yoktur. Sürveyans ve infeksiyon kontrol önlemleri halk sağlığı için hayati öneme sahiptir

Keywords

Coronavirüs Ortadoğu solunum sendromu MERS-CoV polimeraz zincir reaksiyonu solunum semptomları

References

  • De Groot RJ, Baker SC, Baric RS, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the coronavirus
  • study group. J Virol 2013;87:7790-7792.
  • MacIntyre CR. The discrepant epidemiology of Middle East respiratory
  • syndrome coronavirus (MERS-CoV). Environ Syst Decis 2014;34:383-390.
  • Bermingham A, Chand MA, Brown CS, et al. Severe respiratory illness
  • caused by a novel coronavirus, in a patient transferred to the United
  • Kingdom from the Middle East, September 2012. Euro Surveill.
  • ;17:20290.
  • Announcement of the Coronavirus Study Group. Middle East Respiratory Syn 1 drome Coronavirus (MERS-CoV). J. Virol 2013;87:7790-7792.
  • Raj VS, Osterhaus AD, Fouchier RM, et al. MERS: emergence of a
  • novel human coronavirus. Curr Opin Virol 2014;5:58-62.
  • Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel
  • coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012;367:1814-1820.
  • Al-Tawfiq JA, Assiri A, Memish ZA. Middle East respiratory syndrome
  • novel corona (MERS-CoV) infection Epidemiology and outcome update.
  • Saudi Med J 2013;34:991-994.
  • World Health Organization. Global alert and response (GAR): andemic
  • and epidemic diseases (http://www.who.int/csr/disease/en/)
  • Guery B, Poissy J, el Mansouf L, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory syndrome coronavirus: A report of nosocomial transmission. Lancet
  • ;381:2265-2272.
  • Breban R, Riou J, Fontanet A. Interhuman transmissibility of Middle
  • East respiratory syndrome coronavirus: estimation of pandemic risk.
  • Lancet 2013;382:694-699.
  • Memish ZA, Zumla AI, Al-Hakeem RF, et al. Family cluster of Middle
  • East respiratory syndrome coronavirus infections. N Engl J Med
  • ;368:2487-2494.
  • Health Protection Agency (HPA) UK Novel Coronavirus Investigation
  • Team. Evidence of person-to-person transmission within a family
  • cluster of novel coronavirus infections, United Kingdom, February
  • Euro Surveill 2013;18:20427.
  • Puzelli S, Azzi A, Santini MG, et al. Investigation of an imported case of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection
  • in Florence, Italy, May to June 2013. Euro Surveill 2013;18:20564.
  • Abroug F, Slim A, Ouanes-Besbes L. Family cluster of Middle East
  • respiratory syndrome coronavirus infections, Tunisia, 2013 Emerg
  • Infect Dis 2014;20:1527-1530.
  • Assiri A, McGeer A, Perl TM, et al. Hospital outbreak of Middle East
  • respiratory syndrome coronavirus. N Engl J Med 2013;369:407-416.
  • Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of
  • the Middle East respiratory syndrome coronavirus in Saudi Arabia: a
  • descriptive genomic study. Lancet 2013;382:1993-2002.
  • Omrani AS, Matin MA, Haddad Q, et al. A family cluster of Middle East
  • respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case. Int J Infect Dis 2013;17:e668-
  • e672.
  • De Sousa R, Reusken C, Koopmans M. MERS coronavirus: Data
  • gaps for laboratory preparedness. J Clin Virol 2014;59:4-11.
  • Bauch CT, Oraby T. Assessing the pandemic potential of MERS-CoV.
  • Lancet 2013;382:662-664.
  • Drosten C, Seilmaier M, Corman VM, et al. Transmission of MERSCoronavirus in household contacts. N Engl J Med 2014;371:828-835.
  • Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 2013;13:752-761.
  • Memish ZA, Almasri M, Turkestani A, et al. Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program. Int J Infec Dis 2014;25:186-190.
  • Eckerle I, Müller MA, Kallies S, et al. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J 2013;10:359.
  • Memish ZA, Al-Tawfig JA, Makhdoom HQ, et al. Screening for Middle
  • East respiratory syndrome coronavirus infection in hospital patients
  • and their healthcare worker and family contacts: a prospective descriptive study. Clin Microbiol Infect 2014;20(5):469-474.
  • http://who.int/csr/disease/coronavirus_infections/MERS_home
  • Memish MA, Cotton M, Meyer B, et al. Human Infection with MERS
  • Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013.
  • Emerg Infect Dis 2014;20:1012-1015.
  • Reusken CB, Lina PH, Pielaat A, et al. Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study. Lancet Infect Dis 2013;13:859-
  • -
  • Azhar EI, El-Kafrawy S A, Farraj S A, et al. Evidence for Camelto-Human Transmission of MERS Coronavirus. N Engl J Med 2014;370:2499-2505.
  • Cotten M, Watson SJ, Kellam P, et al. Transmission and evolution of
  • the Middle East respiratory syndrome coronavirus in Saudi Arabia: a
  • descriptive genomic study. Lancet 2013;382:1993-2002.
  • Corman V, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction.Euro Surveill 2012;17:20285.
  • Hijawi B, Abdallat M, Sayaydeh A, et al. Novel coronavirus infections
  • in Jordan, April 2012: epidemiological findings from a retrospective
  • investigation. East Mediterr Health J. 2013;19:S12-18.
  • Momattin H, Mohammed K, Zumla A, et al. Therapeutic Options for
  • Middle East Respiratory Syndrome Coronavirus (MERS-CoV) - possible
  • lessons from a systematic review of SARS-CoV therapy. Int J Infect Dis 2013;17:e792-e798.
  • Balkhair A, Al Maamari K, Alawi FB. The struggle against MERS-CoV
  • (The Novel Coronavirus). Oman Med J 2013;28:226-227.
  • Wilde AH, Raj S, Oudshoorn D, et al. MERS-coronavirus replication
  • induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment. J Gen Virol 2013;94:1749-1760.
  • Omrani AS, Saad MM, Baig K, et al. Ribavirin and interferon alfa-2a
  • for severe Middle East respiratory syndrome coronavirus infection:
  • a retrospective cohort study. Lancet Infect Dis 2014;14:1090-1095.
  • Pavli A, Tsiodras S, Maltezou HC. Middle East respiratory syndrome
  • coronavirus (MERS-CoV): Prevention in travelers. Travel Med and
  • Infect Dis 2014;12:602-608.
There are 81 citations in total.

Details

Primary Language English
Journal Section Review
Authors

Emine Parlak

Publication Date July 16, 2015
Published in Issue Year 2015 Volume: 5 Issue: 2

Cite

APA Parlak, E. (2015). Middle East Respiratory Syndrome: MERS. Journal of Microbiology and Infectious Diseases, 5(2), 93-98. https://doi.org/10.5799/ahinjs.02.2015.02.0184
AMA Parlak E. Middle East Respiratory Syndrome: MERS. J Microbil Infect Dis. July 2015;5(2):93-98. doi:10.5799/ahinjs.02.2015.02.0184
Chicago Parlak, Emine. “Middle East Respiratory Syndrome: MERS”. Journal of Microbiology and Infectious Diseases 5, no. 2 (July 2015): 93-98. https://doi.org/10.5799/ahinjs.02.2015.02.0184.
EndNote Parlak E (July 1, 2015) Middle East Respiratory Syndrome: MERS. Journal of Microbiology and Infectious Diseases 5 2 93–98.
IEEE E. Parlak, “Middle East Respiratory Syndrome: MERS”, J Microbil Infect Dis, vol. 5, no. 2, pp. 93–98, 2015, doi: 10.5799/ahinjs.02.2015.02.0184.
ISNAD Parlak, Emine. “Middle East Respiratory Syndrome: MERS”. Journal of Microbiology and Infectious Diseases 5/2 (July 2015), 93-98. https://doi.org/10.5799/ahinjs.02.2015.02.0184.
JAMA Parlak E. Middle East Respiratory Syndrome: MERS. J Microbil Infect Dis. 2015;5:93–98.
MLA Parlak, Emine. “Middle East Respiratory Syndrome: MERS”. Journal of Microbiology and Infectious Diseases, vol. 5, no. 2, 2015, pp. 93-98, doi:10.5799/ahinjs.02.2015.02.0184.
Vancouver Parlak E. Middle East Respiratory Syndrome: MERS. J Microbil Infect Dis. 2015;5(2):93-8.

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