Apelin-13 ve Epilepsi

Abstract

Bir nöropeptid olan Apelin, G proteinine bağlı olan apelin reseptörü APJ'nin tipik bir endojen ligandıdır. Apelin mRNA'sı, proteinleri ve APJ periferik dokularda ve merkezi sinir sisteminde (MSS) yaygın olarak bulunur. Apelin-APJ sistemi epilepsi gibi birçok fizyolojik ve patolojik süreçlere dahil olabilir. Epilepsi ciddi kronik bir nörolojik hastalıktır ve dünya çapında milyonlarca insanı etkilemektedir. Eksitasyon ve inhibisyon arasındaki dengenin bozulması epilepsiye neden olabilir. Apelin ve epilepsi arasındaki ilişkiyi inceleyen az sayıda çalışma bulunmaktadır. Apelinin epilepsi üzerindeki etkisinin aydınlatılması tedavinin geliştirilmesi açısından önemli olacaktır.

Keywords

• Apelin-13
• APJ
• Neuroproteksiyon
• Epilepsi

Apelin-13 and Epilepsy

Abstract

Apelin, a neuropeptide, is a typical endogenous ligand of G protein-coupled apelin receptor, APJ. Apelin mRNAs, proteins and APJ are commonly found in peripheral tissues and the central nervous system (CNS). Thus apelin-APJ system may be related to many physiological and pathological processes such as epilepsy. Epilepsy is severe chronic neurological disease and affects millions of people worldwide. Disruption of the balance between excitation and inhibition can cause epilepsy. There are few studies about apelin and epilepsy interactions. Clarifying the effect of apelin on epilepsy will be important for the development of treatment.

Keywords

• Apelin-13
• APJ
• Neuroprotection
• Epilepsy

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