Research Article
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Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory

Year 2024, Volume: 13 Issue: 2, 165 - 174, 31.08.2024
https://doi.org/10.54187/jnrs.1529229

Abstract

Trifolium pratense L. flowers (TPF) were collected and dried in shade in this study. After extraction in methanol, a diluted solution was applied to the liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) device to determine the bioactive compounds quantitatively. Isoquercitrin (38.64 mg/g extract), coumarin (13.66 mg/g extract), and catechin (12.52 mg/g extract) were verified as major products. Antioxidant activity of TPF was performed using a potentiometric PVC membrane sensor to evaluate 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and total phenolic content of TPF. TPF inhibited the DPPH radical as 31.4 ± 0.02% at the 500-ppm concentration. However, the DPPH activity of gallic acid was determined as 81.43 ± 0.07% and 92.44 ± 0.1% at the TPF concentrations of 12.5 ppm and 25 ppm, respectively. In addition, the total phenolic content was calculated to be 82.4 ± 0.15 mg gallic acid eq/g extract. It was observed that TPF has the potential to be an antioxidant and a valuable source of isoquercitrin, coumarin, and catechin.

Ethical Statement

No approval from the Board of Ethics is required.

References

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Year 2024, Volume: 13 Issue: 2, 165 - 174, 31.08.2024
https://doi.org/10.54187/jnrs.1529229

Abstract

References

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  • M. Elmastas, L. Ozturk, I. Gokce, R. Erenler, H. Y. Aboul‐Enein, Determination of antioxidant activity of marshmallow flower (Althaea officinalis L.), Analytical Letters 37 (9) (2004) 1859-1869.
  • A. Sahin Yaglioglu, B. Akdulum, R. Erenler, I. Demirtas, I. Telci, S. Tekin, Antiproliferative activity of pentadeca-(8E, 13Z) dien-11-yn-2-one and (E)-1,8-pentadecadiene from Echinacea pallida (Nutt.) Nutt. roots, Medicinal Chemistry Research 22 (6) (2013) 2946-2953.
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  • Z. Heyem, B. Nassima, M. Ahmed, R. Erenler, Z. Lahcene, B. Fadila, S. Ameddah, Phytochemical profile, anti-lipid peroxidation and anti-diabetic activities of Thymus algeriensis Boiss. & Reut, Egyptian Journal of Chemistry 65 (12) (2022) 695-705.
  • F. Z. Houari, R. Erenler, A. Hariri, Biological activities and chemical composition of Rubia tinctorum (L.) root and aerial part extracts thereof, Acta Biológica Colombiana 27 (3) (2022) 403-414.
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  • R. Erenler, J. F. Biellmann, Facile conversion of pyridine propargylic alcohols to enones: Stereochemistry of protonation of allenol, Tetrahedron Letters 46 (34) (2005) 5683-5685.
  • O. Cakmak, R. Erenler, A. Tutar, N. Celik, Synthesis of new anthracene derivatives, Journal of Organic Chemistry 71 (5) (2006) 1795-1801.
  • R. Erenler, J. F. Biellmann, Synthesis of pentafluorophenyl- and pyridinyl-3 allenes, Journal of the Chinese Chemical Society 54 (1) (2007) 103-108.
  • R. Erenler, M. Uno, T. V. Goud, J. F. Biellmanna, Preparation of some heterocyclic enones and ynones by isomerisation of the propargylic alcohols, Journal of Chemical Research 2009 (7) (2009) 459-464.
  • J. Lu, I. Maezawa, S. Weerasekara, R. Erenler, T. D. T. Nguyen, J. Nguyen, L. Z. Swisher, J. Li, L.W. Jin, A. Ranjan, S. K. Srivastava, D. H. Hua, Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines, Bioorganic and Medicinal Chemistry Letters 24 (15) (2014) 3392-3397.
  • R. Erenler, S. Yilmaz, H. Aksit, O. Sen, N. Genc, M. Elmastas, I. Demirtas, Antioxidant activities of chemical constituents isolated from Echinops orientalis Trauv, Records of Natural Products 8 (1) (2014) 32-36.
  • E. A. T. Khodja, R. A. Abd El Hamid Khabtane, D. Benouchenne, M. S. Bensaad, C. Bensouici, R. Erenler, In vitro assessment of antioxidant, neuroprotective, anti-urease and anti-tyrosinase capacities of Tamarix africana leaves extracts, Journal of Traditional Chinese Medicine 43 (2) (2023) 252.
  • M. Elmastaş, İ. Telci, H. Akşit, R. Erenler, Comparison of total phenolic contents and antioxidant capacities in mint genotypes used as spices, Turkish Journal of Biochemistry 40 (6) (2015) 456-462.
  • R. Erenler, O. Sen, H. Aksit, I. Demirtas, A. S. Yaglioglu, M. Elmastas, İ. Telci, Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities, Journal of the Science of Food and Agriculture 96 (3) (2016) 822-836.
  • R. Erenler, T. Adak, T. Karan, M. Elmastas, I. Yildiz, H. Aksit, G. Topcu, M. A. Sanda, Chemical Constituents isolated from Origanum solymicum with Antioxidant activities, The Eurasia Proceedings of Science, Technology, Engineering & Mathematics 1 (2017) 139-145.
  • R. Erenler, B. Meral, O. Sen, M. Elmastas, A. Aydin, O. Eminagaoglu, G. Topcu, Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities, Pharmaceutical Biology 55 (1) (2017) 1646-1653.
  • A. Guzel, H. Aksit, M. Elmastas, R. Erenler, Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) Manden. and Scheng., Pharmacognosy Magazine 13 (50) (2017) 316-320.
  • R. Erenler, E. N. Gecer, N. Genc, D. Yanar, Antioxidant activity of silver nanoparticles synthesized from Tagetes erecta L. leaves, International Journal of Chemistry and Technology 5 (2) (2021) 141-146.
  • E.N. Gecer, Green synthesis of silver nanoparticles from Salvia aethiopis L. and their antioxidant activity, Journal of Inorganic and Organometallic Polymers and Materials 31 (11) (2021) 4402-4409.
  • N. Genc, Biosynthesis of silver nanoparticles using Origanum onites extract and investigation of their antioxidant activity, Particulate Science and Technology 39 (5) (2021) 562-568.
  • N. Genc, I. Yildiz, R. Chaoui, R. Erenler, C. Temiz, M. Elmastas, Biosynthesis, characterization and antioxidant activity of oleuropein-mediated silver nanoparticles, Inorganic and Nano-Metal Chemistry 51 (3) (2021) 411-419.
  • B. Dag, Green synthesis, characterization, and antioxidant activity of silver nanoparticles using Stachys annua L. subsp. annua var. annua, Particulate Science and Technology 40 (4) (2022) 512-520.
  • R. Erenler, B. Dag, Biosynthesis of silver nanoparticles using Origanum majorana L. and evaluation of their antioxidant activity, Inorganic and Nano-Metal Chemistry 52 (4) (2022) 485-492.
  • R. Erenler, E. N. Gecer, Green synthesis of silver nanoparticles from Astragalus logopodioides L. leaves, Turkish Journal of Agriculture-Food Science and Technology 10 (6) (2022) 1112-1115.
  • R. Erenler, E. N. Gecer, Synthesis of Silver Nanoparticles Using Sideritis montana L. Leaf Extract: Characterization, catalytic degradation of methylene blue and antioxidant activity, Journal of Nano Research 75 (2022) 17-28.
  • E. N. Gecer, R. Erenler, Biosynthesis of silver nanoparticles using Dittrichia graveolens (Asteraceae) leaves extract: Characterisation and assessment of their antioxidant activity, Turkish Journal of Biodiversity 5 (1) (2022) 50-56.
  • E. N. Gecer, R. Erenler, Biosynthesis of silver nanoparticles using Echinacea pallida (Nutt.) Nutt. and antioxidant activity thereof, Journal of the Chemical Society of Pakistan 44 (6) (2022) 610-617.
  • E. N. Gecer, R. Erenler, C. Temiz, N. Genc, I. Yildiz, Green synthesis of silver nanoparticles from Echinacea purpurea (L.) Moench with antioxidant profile, Particulate Science and Technology 40 (1) (2022) 50-57.
  • T. Karan, R. Erenler, B. Bozer Moran, Synthesis and characterization of silver nanoparticles using curcumin: Cytotoxic, apoptotic, and necrotic effects on various cell lines, Zeitschrift für Naturforschung C 77 (7-8) (2022) 343-350.
  • A. Sahin Yaglioglu, R. Erenler, E. N. Gecer, N. Genc, Biosynthesis of silver nanoparticles using astragalus flavesces leaf: Identification, antioxidant activity, and catalytic degradation of methylene blue, Journal of Inorganic and Organometallic Polymers and Materials 32 (2022) 3700-3707.
  • R. Erenler, R. Chaoui, I. Yildiz, N. Genc, E. N. Gecer, C. Temiz, S. Akkal, Biosynthesis, characterisation, and antioxidant activity of silver nanoparticles using Schinus molle L, Trends in Sciences 20 (10) (2023) 6105-6105.
  • R. Erenler, E. N. Gecer, I. Hosaflioglu, L. Behcet, Green synthesis of silver nanoparticles using Stachys spectabilis: Identification, catalytic degradation, and antioxidant activity, Biochemical and Biophysical Research Communications 659 (2023) 91-95.
  • R. Erenler, I. Hosaflioglu, Green synthesis of silver nanoparticles using Onobrychis sativa L.: Characterization, catalytic degradation of methylene blue, antioxidant activity, and quantitative analysis of bioactive compounds, Materials Today Communications 35 (2023) 105863.
  • R. Erenler, R. A. Ojelade, T. Karan, E. N. Gecer, N. Genc, C. Yaman, Facile, efficient synthesis of silver nanoparticles using Salvia absconditiflora: Assessment of their antioxidant capacity and catalytic activity, Inorganic Chemistry Communications 158 (2023) 111623.
  • E. N. Gecer, Synthesis and characterization of silver nanoparticles using Origanum onites leaves: Cytotoxic, apoptotic, and necrotic effects on Capan-1, L929, and Caco-2 cell lines, Green Processing and Synthesis 12 (1) (2023) Article ID 20228126 8 pages.
  • E. N. Gecer, R. Erenler, Biogenic synthesis of silver nanoparticles using Echium vulgare: Characterisation, quantitative analysis of bioactive compounds, antioxidant activity and catalytic degradation, Journal of the Indian Chemical Society 100 (5) (2023) Article ID 101003 8 pages.
  • T. Karan, R. Erenler, Z. Gonulalan, U. Kolemen, Biogenic synthesis of silver nanoparticles using Sambucus nigra leaves: elucidation, antimicrobial, antioxidant activities and quantification of phenolics, Chemical Papers 78 (1) (2024) 473-481.
  • T. Karan, Z. Gonulalan, R. Erenler, U. Kolemen, O. Eminagaoglu, Green synthesis of silver nanoparticles using Sambucus ebulus leaves extract: Characterization, quantitative analysis of bioactive molecules, antioxidant and antibacterial activities, Journal of Molecular Structure 1296 (2024) Article ID 136836 8 pages.
  • Y. B. Karan, R. Erenler, Synthesis of silver nanoparticles using potato cultivars with their antioxidant activity, Communications in Soil Science and Plant Analysis 55 (9) (2024) 1249-1257.
  • N. Nayel, S. Marah, T. Ozen, I. Yıldız, R. Erenler, L. Behcet, Characterization and comparative investigation of in vitro bioactivities for Lactuca Anatolica root aqueous extract and their green-chemical synthesized nanoparticles; Molecular Docking Studies, BioNanoScience (2024) https://doi.org/10.1007/s12668-024-01353-9
  • A. Seçme, B. M. Bozer, A. Y. Kocaman, R. Erenler, M. H. Calimli, Synthesis, characterization, and anticancer properties of Ag nanoparticles derived from walnut leaves tested on cells of L929, MCF-7 and H1299, Journal of Drug Delivery Science and Technology 94 (2024) Article ID 105478 9 pages.
  • C. Yaman, R. Erenler, M. N. Atalar, Ş. Adem, U. K. Çalişkan, Phytochemical properties, antioxidant and in vitro/in silico anti-acetylcholinesterase activities of hypericum heterophyllum leaf from Türkiye, Brazilian Archives of Biology and Technology 67 (2024) Article ID 24230043 14 pages.
  • F. Z. Houari, M. Brahmi, R. Erenler, A. Hariri, Chemical profile, antibacterial and antioxidant properties of Rubia tinctorum L. essential oils, Natural Product Research (2024) 1-10.
  • B. Bakchiche, G. Hadjira, R. Erenler, İ. Yildiz, A. S. Mohamed, M. A.m. El-shazly, Mineral contents, antioxidant and antimicrobial activities of algerian terfezia claveryi extracts, Fabad Journal of Pharmaceutical Sciences 49 (1) (2024) 19-36.
  • M. Elmastas, S. M. Celik, N. Genc, H. Aksit, R. Erenler, İ. Gulcin, Antioxidant activity of an Anatolian herbal tea—Origanum minutiflorum: Isolation and characterization of its secondary metabolites, International Journal of Food Properties 21 (1) (2018) 374-384.
  • Ö. Isildak, I. Yildiz, N. Genc, A new potentiometric PVC membrane sensor for the determination of DPPH radical scavenging activity of plant extracts, Food Chemistry 373 (2022) Article ID 131420 6 pages.
  • Ö. Işıldak, İ. Yıldız, New potentiometric sensor for total phenolic assay of plant extracts, Bulletin of the Chemical Society of Japan 97 (5) (2024) Article ID uoae043 8 pages.
  • Y. Başar, İ. Hosaflıoğlu, R. Erenler, Phytochemical analysis of Robinia pseudoacacia flowers and leaf: quantitative analysis of natural compounds and molecular docking application, Turkish Journal of Biodiversity 7 (1) (2024) 1-10.
  • I. Demirtas, R. Erenler, M. Elmastas, A. Goktasoglu, Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction, Food Chemistry 136 (1) (2013) 34-40.
  • W. Hassan, G. Rongyin, A. Daoud, L. Ding, L. Wang, J. Liu, J. Shang, Reduced oxidative stress contributes to the lipid-lowering effects of isoquercitrin in free fatty acids induced hepatocytes, Oxidative Medicine and Cellular Longevity 2014 (1) (2014) Article ID 313602 18 pages.
  • X.-M. Peng, G. L. V. Damu, H. Zhou, Current developments of coumarin compounds in medicinal chemistry, Current Pharmaceutical Design 19 (21) (2013) 3884-3930.
  • A. Ganeshpurkar, A. Saluja, The pharmacological potential of catechin, Indian Journal of Biochemistry and Biophysics (IJBB) 57 (5) (2020) 505-511.
  • J. L. Boatwright, K. Pajerowska‐Mukhtar, Salicylic acid: An old hormone up to new tricks, Molecular Plant Pathology 14 (6) (2013) 623-634.
There are 66 citations in total.

Details

Primary Language English
Subjects Sensor Technology
Journal Section Articles
Authors

Ramazan Erenler 0000-0002-0505-3190

İbrahim Hosaflıoğlu 0000-0002-0455-0515

İlyas Yıldız 0000-0003-1254-1069

Mehmet Nuri Atalar 0000-0003-2993-2605

Süleyman Muhammed Çelik 0000-0001-6025-8298

Mehmet Hakkı Alma 0000-0001-7011-3965

Early Pub Date August 30, 2024
Publication Date August 31, 2024
Submission Date August 6, 2024
Acceptance Date August 30, 2024
Published in Issue Year 2024 Volume: 13 Issue: 2

Cite

APA Erenler, R., Hosaflıoğlu, İ., Yıldız, İ., Atalar, M. N., et al. (2024). Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory. Journal of New Results in Science, 13(2), 165-174. https://doi.org/10.54187/jnrs.1529229
AMA Erenler R, Hosaflıoğlu İ, Yıldız İ, Atalar MN, Çelik SM, Alma MH. Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory. JNRS. August 2024;13(2):165-174. doi:10.54187/jnrs.1529229
Chicago Erenler, Ramazan, İbrahim Hosaflıoğlu, İlyas Yıldız, Mehmet Nuri Atalar, Süleyman Muhammed Çelik, and Mehmet Hakkı Alma. “Quantitative Analysis of Phenolics in Trifolium Pratense L. Flowers and Evaluation of Antioxidant Activity by Sensory”. Journal of New Results in Science 13, no. 2 (August 2024): 165-74. https://doi.org/10.54187/jnrs.1529229.
EndNote Erenler R, Hosaflıoğlu İ, Yıldız İ, Atalar MN, Çelik SM, Alma MH (August 1, 2024) Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory. Journal of New Results in Science 13 2 165–174.
IEEE R. Erenler, İ. Hosaflıoğlu, İ. Yıldız, M. N. Atalar, S. M. Çelik, and M. H. Alma, “Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory”, JNRS, vol. 13, no. 2, pp. 165–174, 2024, doi: 10.54187/jnrs.1529229.
ISNAD Erenler, Ramazan et al. “Quantitative Analysis of Phenolics in Trifolium Pratense L. Flowers and Evaluation of Antioxidant Activity by Sensory”. Journal of New Results in Science 13/2 (August 2024), 165-174. https://doi.org/10.54187/jnrs.1529229.
JAMA Erenler R, Hosaflıoğlu İ, Yıldız İ, Atalar MN, Çelik SM, Alma MH. Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory. JNRS. 2024;13:165–174.
MLA Erenler, Ramazan et al. “Quantitative Analysis of Phenolics in Trifolium Pratense L. Flowers and Evaluation of Antioxidant Activity by Sensory”. Journal of New Results in Science, vol. 13, no. 2, 2024, pp. 165-74, doi:10.54187/jnrs.1529229.
Vancouver Erenler R, Hosaflıoğlu İ, Yıldız İ, Atalar MN, Çelik SM, Alma MH. Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory. JNRS. 2024;13(2):165-74.


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