The Effect of Mobile Application on Subcutaneous Anti-TNF Drug Administration in Ankylosing Spondylitis Patients: A Randomized Experimental Study

Year 2025,

Füsun Uzgör , Ayşe Özkaraman , Cengiz Korkmaz

https://doi.org/10.17049/jnursology.1430186

Abstract

Objective: This study was conducted to develop an Android mobile application for the subcutaneous (SC) administration of anti-TNF drugs in ankylosing spondylitis patients and to evaluate its effect on drug administration.

Methods: In the first stage of this randomized experimental study, a mobile application for SC anti-TNF drug therapy was developed. In the second stage, 32 patients who met the sampling criteria were randomized to mobil and booklet groups. Patients in both groups were evaluated using the Individual Identification Form, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), the Ankylosing Spondylitis Quality of Life Scale (ASQoL) and Subcutaneous Anti-TNF Treatment Questionnaire once every 6 weeks for 6 months.

Results: In the first stage, the concordance coefficient of the five experts’ opinions on the information provided in the mobile application was calculated as W:0.272, P=.130. For both patient groups, the mean scores of BASDAI, BASFI, and ASQoL were statistically significantly lower at the last evaluation than at the first. More patients in the education booklet group had their medication applied by someone else (P=.011).

Conclusion: The mobile application developed for SC anti-TNF therapy in AS patients is highly informative and reliable, and it facilitates the administration of SC anti-TNF drugs to patients.

Keywords

Ankylosing spondylitis, tumor necrosis factor inhibitors, subcutaneous injections, mobile applications, nursing

Project Number

2017.2_16

Ankilozan Spondilit Hastalarında Mobil Uygulamanın Subkütan Anti-TNF İlaç Uygulamasına Etkisi: Randomize Deneysel Bir Çalışma

Abstract

Amaç: Bu çalışma, ankilozan spondilit (AS) hastalarının subkütan (SC) anti-TNF ilaç uygulamasına yönelik bir Android mobil uygulama geliştirmek ve bu uygulamanın ilaç uygulamasına etkisini değerlendirmek amacıyla yapıldı.

Yöntemler: Bu deneysel çalışmanın ilk aşamasında SC anti-TNF ilaç tedavisine yönelik mobil bir uygulama geliştirildi. İkinci aşamada örnekleme kriterlerini karşılayan 32 hasta mobil ve kitapçık gruplarına randomize edildi. Her iki gruptaki hastalar 6 ay boyunca her 6 haftada bir Bireysel Tanıtım Formu, Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI), Bath Ankilozan Spondilit Fonksiyonel İndeksi (BASFI), Ankilozan Spondilit Yaşam Kalitesi Anketi (ASQoL) ve Subkütan Anti-TNF Tedavi Anketi kullanılarak değerlendirildi.

Bulgular: İlk aşamada 5 uzmanın mobil uygulamada sunulan bilgilere ilişkin görüşlerinin uyum katsayısı W:0,272, P=.130 olarak hesaplandı. Her iki hasta grubunda da BASDAI, BASFI ve ASQoL ortalama puanları son değerlendirmede ilk değerlendirmeye göre istatistiksel olarak anlamlı derecede düşüktü. Eğitim kitapçığı grubunda ilacını başkasına yaptıran hasta sayısı daha fazlaydı (P=.011).

Sonuç: AS hastalarında SC anti-TNF tedavisi için geliştirilen mobil uygulamanın bilgi kalitesi ve güvenilirliği yüksek olup hastaların SC anti-TNF ilaçları uygulamasını kolaylaştırmıştır.

Keywords

Ankilozan spondilit, Tümör nekroz faktörü inhibitörleri, subkütan enjeksiyonlar, mobil uygulamalar, hemşirelik

Supporting Institution

Koç University Semahat Arsel Nursing Education and Research Center (SANERC).

Project Number

2017.2_16

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