Research Article
BibTex RIS Cite

Does Surgical Technique Influence Radial and Axillary Nerve Injury After Long PHILOS Plate Fixation in Proximally Extending Humeral Shaft Fractures?

Year 2026, Volume: 2 Issue: 1 , 8 - 13 , 30.03.2026
https://doi.org/10.5281/zenodo.18997903
https://izlik.org/JA57WG96TJ

Abstract

Abstract Background: Proximally extending humeral shaft fractures (PEHSFs) pose significant surgical challenges due to the complex fracture anatomy and proximity to the axillary and radial nerves. While long proximal humeral internal locking system (PHILOS) plates are commonly used, the impact of surgical technique and implant length on neurological safety remains unclear. This study aimed to evaluate the relationship between surgical technique (Open Reduction–Internal Fixation [ORIF] versus Minimally Invasive Plate Osteosynthesis [MIPO]) and the occurrence of iatrogenic nerve palsy in patients with PEHSFs. Methods: A retrospective study was conducted on 18 patients treated with long PHILOS plates for PEHSFs between January 2022 and January 2025. Patients were stratified into ORIF (n=10) and MIPO (n=8) groups. Axillary and radial nerve functions were assessed preoperatively, immediately postoperatively, and at the final follow-up. The impact of surgical approach, intraoperative nerve exploration, and plate length (9-, 11-, and 12-hole) on neurological outcomes were analyzed. Results: The overall rate of immediate postoperative nerve palsy was 16.7% for the axillary nerve and 22.2% for the radial nerve. After a median follow-up of 8 months, persistent nerve palsy was observed in 3 patients (16.7%). Although the difference did not reach statistical significance (p=0.147), all permanent nerve injuries occurred in the ORIF group (30%), whereas no long-term deficits were observed in the MIPO group (0%). A statistically significant association was identified between plate length and persistent nerve palsy (p=0.002); all cases of permanent nerve palsy were associated with the use of 12-hole plates. Conclusion: While MIPO demonstrated a favorable safety profile with no permanent nerve injuries, the use of 12-hole long locking plates emerged as a significant independent risk factor for persistent neurological deficit in PEHSFs. These findings suggest that adopting soft-tissue-sparing techniques and selecting the shortest implant capable of providing adequate stability may reduce the risk of iatrogenic nerve injury.

References

  • Aksu, N., Karaca, S., Kara, A. N., & Işiklar, Z. U. (2012). Minimally invasive plate osteosynthesis (MIPO) in diaphyseal humerus and proximal humerus fractures. Acta Orthopaedica et Traumatologica Turcica, 46(3), 154–160. https://doi.org/10.3944/aott.2012.2592
  • Bergdahl, C., Ekholm, C., Wennergren, D., Nilsson, F., & Möller, M. (2016). Epidemiology and patho-anatomical pattern of 2,011 humeral fractures: Data from the Swedish Fracture Register. BMC Musculoskeletal Disorders, 17, 159. https://doi.org/10.1186/s12891-016-1009-8
  • Boadi, P. J., Da Silva, A., Mizels, J., Joyce, C. D., Anakwenze, O. A., Klifto, C. S., & Chalmers, P. N. (2024). Intramedullary versus locking plate fixation for proximal humerus fractures: Indications and technical considerations. JSES Reviews, Reports & Techniques, 4(3), 615–624. https://doi.org/10.1016/j.xrrt.2024.01.001
  • Carlan, D., Pratt, J., Patterson, J. M., Weiland, A. J., Boyer, M. I., & Gelberman, R. H. (2007). The radial nerve in the brachium: An anatomic study in human cadavers. Journal of Hand Surgery (American Volume), 32(8), 1177–1182. https://doi.org/10.1016/j.jhsa.2006.07.001
  • Cho, E., Schoenfeldt, T., McMartin, T., Summers, H., Cohen, J. B., & Levack, A. E. (2023). Proximal fracture line extension in humeral shaft fractures. Journal of Clinical Orthopaedics and Trauma, 44, 102248. https://doi.org/10.1016/j.jcot.2023.102248
  • Contreras, J. J., Meissner, A., Valenzuela, A., Liendo, R., de Marinis, R., Calvo, C., & Soza, F. (2022). Establishing safe zones to avoid nerve injury in the posterior minimally invasive plate osteosynthesis for humerus fractures: A magnetic resonance imaging study. JSES International, 6(6), 1015–1022. https://doi.org/10.1016/j.jseint.2022.08.003
  • Esmailiejah, A. A., Abbasian, M. R., Safdari, F., & Ashoori, K. (2015). Treatment of humeral shaft fractures: Minimally invasive plate osteosynthesis versus open reduction and internal fixation. Trauma Monthly, 20(3), e26271. https://doi.org/10.5812/traumamon.26271
  • Hegeman, E. M., Polmear, M., Scanaliato, J. P., Nesti, L., & Dunn, J. C. (2020). Incidence and management of radial nerve palsies in humeral shaft fractures: A systematic review. Cureus, 12(11), e11490. https://doi.org/10.7759/cureus.11490
  • Jiamton, C., Rungchamrussopa, P., Taweekitikul, P., Leelasestaporn, T., Anantasinkul, P., & Apivatthakakul, T. (2024). Lateral minimally invasive plate osteosynthesis (MIPO) with long PHILOS for proximal metaphyseal-diaphyseal humeral fracture: Surgical techniques and a clinical series. European Journal of Orthopaedic Surgery & Traumatology, 34(1), 689–697. https://doi.org/10.1007/s00590-023-03722-8
  • Li, F., Liu, X., Wang, F., Gu, Z., Tao, Q., Yao, C., Luo, X., & Nie, T. (2019). Comparison between minimally invasive plate osteosynthesis and open reduction–internal fixation for proximal humeral fractures: A meta-analysis based on 1050 individuals. BMC Musculoskeletal Disorders, 20(1), 550. https://doi.org/10.1186/s12891-019-2936-y
  • Li, Y., Ning, G., Wu, Q., Wu, Q., Li, Y., & Feng, S. (2013). Review of literature of radial nerve injuries associated with humeral fractures—An integrated management strategy. PLoS ONE, 8(11), e78576. https://doi.org/10.1371/journal.pone.0078576
  • Marmor, M. T., Agel, J., Dumpe, J., Kellam, J. F., Marecek, G. S., Meinberg, E., Nguyen, M. P., Sims, S., Soles, G. L., & Karam, M. D. (2022). Comparison of the Neer classification to the 2018 update of the Orthopedic Trauma Association/AO fracture classification for classifying proximal humerus fractures. OTA International, 5(3), e200. https://doi.org/10.1097/OI9.0000000000000200
  • Palm, D. S., Parikh, P. P., Schoonover, B., Lebamoff, D., & McCarthy, M. C. (2013). Axillary arterial entrapment and brachial plexus injury due to proximal humeral fracture. Injury Extra, 44(8), 67–69. https://doi.org/10.1016/j.injury.2013.05.010
  • Pimple, M., Chidambaram, R., & Mok, D. (2010). Long PHILOS plate fixation for complex humeral fractures. Shoulder & Elbow, 2, 10–15. https://doi.org/10.1111/j.1758-5740.2010.00085.x
  • Rancan, M., Dietrich, M., Lamdark, T., Can, U., & Platz, A. (2010). Minimal invasive long PHILOS® plate osteosynthesis in metadiaphyseal fractures of the proximal humerus. Injury, 41(12), 1277–1283. https://doi.org/10.1016/j.injury.2010.07.235
  • Rocchi, M., Tarallo, L., Mugnai, R., & Adani, R. (2016). Humerus shaft fracture complicated by radial nerve palsy: Is surgical exploration necessary? Musculoskeletal Surgery, 100(Suppl 1), 53–60. https://doi.org/10.1007/s12306-016-0414-3
  • Saran, N., Bergeron, S. G., Benoit, B., Reindl, R., Harvey, E. J., & Berry, G. K. (2010). Risk of axillary nerve injury during percutaneous proximal humerus locking plate insertion using an external aiming guide. Injury, 41(10), 1037–1040. https://doi.org/10.1016/j.injury.2010.04.014
  • Shao, Y. C., Harwood, P., Grotz, M. R. W., Limb, D., & Giannoudis, P. V. (2005). Radial nerve palsy associated with fractures of the shaft of the humerus: A systematic review. Journal of Bone and Joint Surgery. British Volume, 87(12), 1647–1652. https://doi.org/10.1302/0301-620X.87B12.16132 Tubbs, R. S., Oakes, W. J., Blount, J. P., Elton, S., Salter, G., & Grabb, P. A. (2001). Surgical landmarks for the proximal portion of the axillary nerve. Journal of Neurosurgery, 95(6), 998–1000. https://doi.org/10.3171/jns.2001.95.6.0998
  • Wang, J., Wei, Y., Yang, Y., Guo, X., Liu, Z., Lin, H., & Yang, X. (2025). A new method of predicting radial nerve location: A cadaveric study. Anatomical Science International. Advance online publication. https://doi.org/10.1007/s12565-025-00880-z
  • Yang, J., Liu, D., Zhang, L., Lu, Z., Liu, T., & Tao, C. (2021). Treatment of humeral shaft fractures: A new minimally invasive plate osteosynthesis versus open reduction and internal fixation: A case-control study. BMC Surgery, 21(1), 349. https://doi.org/10.1186/s12893-021-01347-4
  • Younis, Z., Hamid, M. A., Amin, J., Khan, M. M., Gurukiran, G., Sapra, R., Singh, R., Wani, K. F., & Younus, Z. (2024). Proximal humerus fractures: A review of anatomy, classification, management strategies, and complications. Cureus, 16(11), e73075. https://doi.org/10.7759/cureus.73075
  • Zhang, Z., Lin, Z., Qiu, Q., Xiao, X., Su, S., Wen, X., & He, B. (2024). Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury. European Journal of Medical Research, 29(1), 385. https://doi.org/10.1186/s40001-024-01981-7
  • Zlotolow, D. A., Catalano, L. W., Barron, O. A., & Glickel, S. Z. (2006). Surgical exposures of the humerus. Journal of the American Academy of Orthopaedic Surgeons, 14(13), 754–765. https://doi.org/10.5435/00124635-200612000-00007

Proksimale Uzanan Humerus Cisim Kırıklarında Uzun PHILOS Plak Fiksasyonu Sonrası Radial ve Aksiller Sinir Yaralanmalarını Cerrahi Teknik Etkiler mi?

Year 2026, Volume: 2 Issue: 1 , 8 - 13 , 30.03.2026
https://doi.org/10.5281/zenodo.18997903
https://izlik.org/JA57WG96TJ

Abstract

Amaç: Proksimale uzanan humerus cisim kırıkları (PEHSF’ler), karmaşık kırık anatomisi ve aksiller ile radial sinirlere olan yakınlık nedeniyle önemli cerrahi zorluklar oluşturur. Uzun proksimal humerus internal kilitli sistem (PHILOS) plakları yaygın olarak kullanılmasına rağmen, cerrahi teknik ve implant uzunluğunun nörolojik güvenlik üzerindeki etkisi net değildir. Bu çalışmanın amacı, PEHSF’li hastalarda cerrahi teknik (Açık Redüksiyon–İnternal Fiksasyon [ARİF] ve Minimal İnvaziv Plak Osteosentezi [MIPO]) ile iyatrojenik sinir felci gelişimi arasındaki ilişkiyi değerlendirmektir. Yöntemler: Ocak 2022–Ocak 2025 tarihleri arasında PEHSF nedeniyle uzun PHILOS plakları ile tedavi edilen 18 hasta retrospektif olarak incelendi. Hastalar ARİF (n=10) ve MIPO (n=8) gruplarına ayrıldı. Aksiller ve radial sinir fonksiyonları preoperatif dönemde, ameliyat sonrası erken dönemde ve son kontrolde değerlendirildi. Cerrahi yaklaşım, intraoperatif sinir eksplorasyonu ve plak uzunluğunun (9, 11 ve 12 delikli) nörolojik sonuçlar üzerindeki etkisi analiz edildi. Bulgular: Ameliyat sonrası erken dönemde sinir felci oranı aksiller sinir için %16,7, radial sinir için %22,2 olarak saptandı. Medyan 8 aylık takip süresi sonunda, 3 hastada (%16,7) kalıcı sinir felci izlendi. İstatistiksel olarak anlamlılığa ulaşmamakla birlikte (p=0,147), kalıcı sinir yaralanmalarının tamamı ORIF grubunda (%30) görülürken, MIPO grubunda uzun dönem nörolojik defisit izlenmedi (%0). Plak uzunluğu ile kalıcı sinir felci arasında istatistiksel olarak anlamlı bir ilişki saptandı (p=0,002); kalıcı sinir felci gelişen tüm olgularda 12 delikli plak kullanılmıştı. Sonuç: MIPO tekniği kalıcı sinir yaralanması izlenmemesiyle daha güvenli bir profil sergilerken, 12 delikli uzun kilitli plak kullanımı PEHSF’lerde kalıcı nörolojik defisit için anlamlı ve bağımsız bir risk faktörü olarak belirlendi. Bu bulgular, yumuşak dokuya saygılı cerrahi tekniklerin tercih edilmesinin ve yeterli stabiliteyi sağlayabilecek en kısa implantın seçilmesinin iyatrojenik sinir yaralanması riskini azaltabileceğini düşündürmektedir. Anahtar Kelimeler: Humerus kırığı; Radial sinir felci; Aksiller sinir felci; PHILOS plak; MIPO; ORIF.

References

  • Aksu, N., Karaca, S., Kara, A. N., & Işiklar, Z. U. (2012). Minimally invasive plate osteosynthesis (MIPO) in diaphyseal humerus and proximal humerus fractures. Acta Orthopaedica et Traumatologica Turcica, 46(3), 154–160. https://doi.org/10.3944/aott.2012.2592
  • Bergdahl, C., Ekholm, C., Wennergren, D., Nilsson, F., & Möller, M. (2016). Epidemiology and patho-anatomical pattern of 2,011 humeral fractures: Data from the Swedish Fracture Register. BMC Musculoskeletal Disorders, 17, 159. https://doi.org/10.1186/s12891-016-1009-8
  • Boadi, P. J., Da Silva, A., Mizels, J., Joyce, C. D., Anakwenze, O. A., Klifto, C. S., & Chalmers, P. N. (2024). Intramedullary versus locking plate fixation for proximal humerus fractures: Indications and technical considerations. JSES Reviews, Reports & Techniques, 4(3), 615–624. https://doi.org/10.1016/j.xrrt.2024.01.001
  • Carlan, D., Pratt, J., Patterson, J. M., Weiland, A. J., Boyer, M. I., & Gelberman, R. H. (2007). The radial nerve in the brachium: An anatomic study in human cadavers. Journal of Hand Surgery (American Volume), 32(8), 1177–1182. https://doi.org/10.1016/j.jhsa.2006.07.001
  • Cho, E., Schoenfeldt, T., McMartin, T., Summers, H., Cohen, J. B., & Levack, A. E. (2023). Proximal fracture line extension in humeral shaft fractures. Journal of Clinical Orthopaedics and Trauma, 44, 102248. https://doi.org/10.1016/j.jcot.2023.102248
  • Contreras, J. J., Meissner, A., Valenzuela, A., Liendo, R., de Marinis, R., Calvo, C., & Soza, F. (2022). Establishing safe zones to avoid nerve injury in the posterior minimally invasive plate osteosynthesis for humerus fractures: A magnetic resonance imaging study. JSES International, 6(6), 1015–1022. https://doi.org/10.1016/j.jseint.2022.08.003
  • Esmailiejah, A. A., Abbasian, M. R., Safdari, F., & Ashoori, K. (2015). Treatment of humeral shaft fractures: Minimally invasive plate osteosynthesis versus open reduction and internal fixation. Trauma Monthly, 20(3), e26271. https://doi.org/10.5812/traumamon.26271
  • Hegeman, E. M., Polmear, M., Scanaliato, J. P., Nesti, L., & Dunn, J. C. (2020). Incidence and management of radial nerve palsies in humeral shaft fractures: A systematic review. Cureus, 12(11), e11490. https://doi.org/10.7759/cureus.11490
  • Jiamton, C., Rungchamrussopa, P., Taweekitikul, P., Leelasestaporn, T., Anantasinkul, P., & Apivatthakakul, T. (2024). Lateral minimally invasive plate osteosynthesis (MIPO) with long PHILOS for proximal metaphyseal-diaphyseal humeral fracture: Surgical techniques and a clinical series. European Journal of Orthopaedic Surgery & Traumatology, 34(1), 689–697. https://doi.org/10.1007/s00590-023-03722-8
  • Li, F., Liu, X., Wang, F., Gu, Z., Tao, Q., Yao, C., Luo, X., & Nie, T. (2019). Comparison between minimally invasive plate osteosynthesis and open reduction–internal fixation for proximal humeral fractures: A meta-analysis based on 1050 individuals. BMC Musculoskeletal Disorders, 20(1), 550. https://doi.org/10.1186/s12891-019-2936-y
  • Li, Y., Ning, G., Wu, Q., Wu, Q., Li, Y., & Feng, S. (2013). Review of literature of radial nerve injuries associated with humeral fractures—An integrated management strategy. PLoS ONE, 8(11), e78576. https://doi.org/10.1371/journal.pone.0078576
  • Marmor, M. T., Agel, J., Dumpe, J., Kellam, J. F., Marecek, G. S., Meinberg, E., Nguyen, M. P., Sims, S., Soles, G. L., & Karam, M. D. (2022). Comparison of the Neer classification to the 2018 update of the Orthopedic Trauma Association/AO fracture classification for classifying proximal humerus fractures. OTA International, 5(3), e200. https://doi.org/10.1097/OI9.0000000000000200
  • Palm, D. S., Parikh, P. P., Schoonover, B., Lebamoff, D., & McCarthy, M. C. (2013). Axillary arterial entrapment and brachial plexus injury due to proximal humeral fracture. Injury Extra, 44(8), 67–69. https://doi.org/10.1016/j.injury.2013.05.010
  • Pimple, M., Chidambaram, R., & Mok, D. (2010). Long PHILOS plate fixation for complex humeral fractures. Shoulder & Elbow, 2, 10–15. https://doi.org/10.1111/j.1758-5740.2010.00085.x
  • Rancan, M., Dietrich, M., Lamdark, T., Can, U., & Platz, A. (2010). Minimal invasive long PHILOS® plate osteosynthesis in metadiaphyseal fractures of the proximal humerus. Injury, 41(12), 1277–1283. https://doi.org/10.1016/j.injury.2010.07.235
  • Rocchi, M., Tarallo, L., Mugnai, R., & Adani, R. (2016). Humerus shaft fracture complicated by radial nerve palsy: Is surgical exploration necessary? Musculoskeletal Surgery, 100(Suppl 1), 53–60. https://doi.org/10.1007/s12306-016-0414-3
  • Saran, N., Bergeron, S. G., Benoit, B., Reindl, R., Harvey, E. J., & Berry, G. K. (2010). Risk of axillary nerve injury during percutaneous proximal humerus locking plate insertion using an external aiming guide. Injury, 41(10), 1037–1040. https://doi.org/10.1016/j.injury.2010.04.014
  • Shao, Y. C., Harwood, P., Grotz, M. R. W., Limb, D., & Giannoudis, P. V. (2005). Radial nerve palsy associated with fractures of the shaft of the humerus: A systematic review. Journal of Bone and Joint Surgery. British Volume, 87(12), 1647–1652. https://doi.org/10.1302/0301-620X.87B12.16132 Tubbs, R. S., Oakes, W. J., Blount, J. P., Elton, S., Salter, G., & Grabb, P. A. (2001). Surgical landmarks for the proximal portion of the axillary nerve. Journal of Neurosurgery, 95(6), 998–1000. https://doi.org/10.3171/jns.2001.95.6.0998
  • Wang, J., Wei, Y., Yang, Y., Guo, X., Liu, Z., Lin, H., & Yang, X. (2025). A new method of predicting radial nerve location: A cadaveric study. Anatomical Science International. Advance online publication. https://doi.org/10.1007/s12565-025-00880-z
  • Yang, J., Liu, D., Zhang, L., Lu, Z., Liu, T., & Tao, C. (2021). Treatment of humeral shaft fractures: A new minimally invasive plate osteosynthesis versus open reduction and internal fixation: A case-control study. BMC Surgery, 21(1), 349. https://doi.org/10.1186/s12893-021-01347-4
  • Younis, Z., Hamid, M. A., Amin, J., Khan, M. M., Gurukiran, G., Sapra, R., Singh, R., Wani, K. F., & Younus, Z. (2024). Proximal humerus fractures: A review of anatomy, classification, management strategies, and complications. Cureus, 16(11), e73075. https://doi.org/10.7759/cureus.73075
  • Zhang, Z., Lin, Z., Qiu, Q., Xiao, X., Su, S., Wen, X., & He, B. (2024). Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury. European Journal of Medical Research, 29(1), 385. https://doi.org/10.1186/s40001-024-01981-7
  • Zlotolow, D. A., Catalano, L. W., Barron, O. A., & Glickel, S. Z. (2006). Surgical exposures of the humerus. Journal of the American Academy of Orthopaedic Surgeons, 14(13), 754–765. https://doi.org/10.5435/00124635-200612000-00007
There are 23 citations in total.

Details

Primary Language English
Subjects Orthopaedics
Journal Section Research Article
Authors

Orhan Mert 0000-0001-6634-1797

Soner Sarı 0000-0001-8863-9332

Berat Mert Aktaş 0009-0007-8591-3763

Furkan Hanege 0000-0001-9511-1608

Batuhan Gencer 0000-0003-0041-7378

Özgür Doğan 0000-0002-5913-0411

Submission Date December 30, 2025
Acceptance Date February 10, 2026
Publication Date March 30, 2026
DOI https://doi.org/10.5281/zenodo.18997903
IZ https://izlik.org/JA57WG96TJ
Published in Issue Year 2026 Volume: 2 Issue: 1

Cite

APA Mert, O., Sarı, S., Aktaş, B. M., Hanege, F., Gencer, B., & Doğan, Ö. (2026). Does Surgical Technique Influence Radial and Axillary Nerve Injury After Long PHILOS Plate Fixation in Proximally Extending Humeral Shaft Fractures? Journal of Baltalimanı, 2(1), 8-13. https://doi.org/10.5281/zenodo.18997903