Protection against the cisplatin-induced testis injury by administering Ceratonia siliqua L. extract in Sprague dawley rats

Year 2022, Volume: 1 Issue: 1, 1 - 11, 13.10.2022

Gülşah Yıldız Deniz Esra Laloglu Selim Comaklı Arzu Gezer Nimet Yıgıt

Abstract

The purpose of this study was to show the possible ameliorative effect of Ceratonia siliqua L. (CS) extract on the cisplatin (CP) induced testis damage in rats. The physiological saline was applied to the control group and CS was injected in two different doses for two groups, that is, the low-dose CS group and the high dose group. The CP injection was divided into three groups (CP group, CP + low dose CS group, CP + high dose CS group). At the end of the experiment, the animals were sacrificed and their testis tissues were removed for the biochemical and histopathological investigation. Total antioxidant status (TAS) and total oxidant status (TOS) levels were determined and finally the histopathological changes int he testis tissues were examined using hematoxylin-eosin staining method. It was found that applying CS extract could revert the level of fertility hormones and suppress the histomorphological alterations and DNA damages. CS provided the evidence that it might have a therapeutic role in free radical mediated diseases.

Keywords

Chemotherapy, Ceratonia siliqua, Cisplatin, Cu / Zn SOD, Sprague dawley, Testis.

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