SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES

Abstract

Hydrazones were considered as signiŞcant substrates in drug discovery process. Therefore, a seriesof some new 1- 4- 1- 2- 4-substitutedphenyl hydrazono ethyl phenyl -3- 4-nitrophenyl ureaderivatives were synthesized as potential urease inhibitory agents. The synthesizedcompounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis C, H, N . Allcompounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds,8, 7, 6, and 4 showed excellent activities IC50 i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and22.95±0.47 µM, respectively. This study has culminated in the identiŞcation of some compoundswhich can serve as leads for new potent urease inhibitors

Keywords

• organic synthesis,Urease inhibition activity,Hydrazone,Enzyme inhibitors,Urea

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