Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials
Abstract
Prostate cancer is perhaps the most dominant cancer in men. The increased resistance to therapeutic agents and deficiency of targeted therapy for prostate cancer cells offer motivation to find new scaffolds for the treatment. The current study investigates substituted biscoumarin analogs (1-19) anticancer activity in the prostate cancer (PC3) cell line and its antioxidant potential. Out of these nineteen analogs, the compounds 1, 8, 9, 10, 12, 14, 16, 18 and 19 showed good PC3 cell line inhibitory potential when compared with the standard doxorubicin. Compounds 1-19 were also checked for DPPH radical scavenging potential. Compounds 2, 5, and 17 showed good potential. All analogs were also evaluated for superoxide anion scavenging activity and found to be inactive. The docking analysis shows that the biscoumarin is an anti-cancer ligand and has the ability to inhibit the activity of the human histone acetyltransferase. Overall this study has contributed for anticancer and antioxidant agents.
Keywords
References
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Details
Primary Language
English
Subjects
Organic Chemistry
Journal Section
Research Article
Publication Date
July 15, 2020
Submission Date
April 13, 2020
Acceptance Date
-
Published in Issue
Year 2020 Volume: 5 Number: 1