Nasopharyngeal and laryngeal amyloidosis: a case report

Abstract

A 49-year-old woman admitted to our clinic due to a progressive hoarse voice for 4 years, foreign body sensation in the back of her throat, otalgia, hoarseness and mouth breathing. Nasolaryngoscopy demonstrated a right nasopharyngeal mass extending to oropharynx. Indirect laryngoscopy revealed a granulomatous lesion originating from right band ventricle and extending on the right vocal fold. The granulomatous lesion did not alter correct laryngeal mobility. There was no history of difficulty in swallowing. A contrast enhanced computed tomography showed a smooth mass involving nasopharynx and glottis. A direct laryngoscopy was planned for excisional biopsy of the lesion. Histopathological examination revealed nasopharyngeal and laryngeal amyloidosis. Further evaluations were negative for systemic amyloidosis. The aim of the report is to present an extremely rare case of isolated primary nasopharyngeal and laryngeal amyloidosis and discuss by using current literature knowledge.

Keywords

• Primary amyloidosis, nasopharynx, larynx

Nazofarenks ve larenks amiloidozisi: Bir olgu sunumu

Abstract

Kırk dokuz yaşındaki kadın hasta 4 yıldan beri ilerleyen kısık ses, boğazının arka tarafında yabancı cisim hissi, kulak ağrısı, ses kısıklığı ve ağızdan soluma yakınmalarıyla kliniğimize kabul edildi. Nazolarengoskopi orofarenkse doğru uzanan bir sağ nazofarengeal kitleyi göstermekteydi. İndirekt larengoskopi sağ ventrikül bandından kaynaklanan ve sağ vokal kordun üzerine doğru uzanan bir granülomatöz kitleyi ortaya çıkardı. Granülomatöz kitle normal larenks mobilitesini bozmuyordu. Yutma zorluğu öyküsü yoktu. Kontrastlı bilgisayarlı tomografi nazofarenks ve glotisi tutan düzgün yüzeyli bir kitlenin var olduğunu gösterdi. Lezyonun eksizyonel biyopsisi için direkt larengoskopi planlandı. Histopatolojik inceleme nazofarenks ve larenks amiloidozunu ortaya çıkardı. İleri değerlendirmelerde sistemik amiloidoz saptanmadı. Bu olgu sunumunun amacı son derecede seyrek görülen izole primer nazofarenks ve larenks amiloidozu olgusunu sunmak ve güncel literatür bilgilerini kullanarak tartışmaktır.

Keywords

• Primer amiloidoz, nazofarenks, larenks

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19. Please cite this article as: Yurttafl V, Bozdemir K, Tarlak B, Yazgan A. Nasopharyngeal and laryngeal amyloidosis: a case report. J Med Updates 2014;4(3):130–133.