Investigation of the effects of fascia lata on neochondrogenesis in a rabbit model

Abstract

Objective: The impact of fascia lata on neochondrogenesis placed between both leaflets of the perichondrium after full thickness submucoperichondrial cartilage resection was investigated in a rabbit septum model. Methods: Twenty adult New Zealand rabbits were studied in two groups with equal number of animals in each group. Full thickness cartilage with an area of 1 cm² was resected to create a cartilage defect in all rabbits. Autogenous fascia lata was interposed between both leaflets of the perichondrium and the surgical field was closed (fascia lata group). Any material was not interposed between both leaflets of the perichondrium of the defective area (control group). Rabbits were sacrificed on postoperative 90th days and their septa were totally excised. Neochondrogenesis was investigated histopathologically with a light microscope. The preparations were evaluated as for thickness of newly formed cartilage (in mm), inflammatory reaction and presence of macroscopic perforation. Results: Thickness of the cartilage in the fascia lata group was significantly greater than that of the control group (M-W-U=15,000, p

Keywords

• Neochondrogenesis, nasal septum, fascia lata

Fasia latanın neokondrogenezis üzerine olan etkilerinin tavşan modelinde araştırılması

Öz

Amaç: Submukoperikondrial tam kat kıkırdak rezeksiyonu sonrası her iki perikondrium yaprağı arasına konan fasia latanın neokondrogenezis üzerine olan etkilerinin araştırılması. Yöntem: Yirmi adet genç erişkin Yeni Zelanda tavşanı eşit sayıda iki gruba ayrıldı. Her tavşanın nazal septumlarından 1 cm²'lik tam kat kıkırdak rezeksiyonu yapıldı. Oluşan kıkırdak defektine ilk grupta tavşanın kendisinden alınan fasia lata submukoperikondrial olarak yerleştirildi (fasia lata grubu). Diğer gruba herhangi bir materyal konmadı (kontrol grubu). Operasyon sonrası 90. günde defekt bölgesini de içine alacak şekilde subtotal septum rezeksiyonu yapıldı. Yeni kıkırdak oluşumu histopatolojik olarak, ışık mikroskobuyla incelendi. Değerlendirmede perikondrium kökenli yeni kıkırdak oluşumu, iltihabi reaksiyon ve nekroz, makroskopik olarak da perforasyon oluşumu göz önüne alındı. Bulgular: Fasia lata yerleştirilen çalışma grubunda oluşan yeni kıkırdak dokusu kontrol grubuna oranla anlamlı derecede fazla bulundu (M-W-U=15.000, p

Anahtar Kelimeler

• Neokondrogenezis, nazal septum, fasia lata

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23. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY
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26. Please cite this article as: Yılmaz Ş, Bilkay Ö, Özdemir ‹, Avcı A, Adadan Güvenç I. Investigation of the effects of fascia lata on neochondrogenesis in
27. a rabbit model. J Med Updates 2014;4(2):66-70.