Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome

Abstract

Stiff person syndrome(SPS) is a rare clinical condition which is characterized by progressive muscle stiffness, rigidity and muscle spasms which are worsened by emotional stres and some triggers. SPS has three variants : autoimmune, idiopathic and paraneoplastic. Paraneoplastic variant is associated with neoplasms. There is non-organ-spesifi c antibodies, but
not anti-GAD or anti-islet cell antibodies in circulation. Paraneoplastic variant was reported in patients with breast cancer and small cell lung cancer before. However, there is no report with pancreatic cancer at literature. We think that this case is the fi rst one showing the relation of SPS with pancreatic cancer.

Keywords

• Stiff person syndrome,paraneoplastic,pancreatic cancer

Stiff Person Syndrome in A Patient With Pancreatic Adenocarcinoma: An Unusual Paraneoplastic Syndrome

Abstract

Stiff person sendromu (SPS), progresif kas katılığı, rijiditesi ve kas spazmı ile giden, emosyonel stress ve bazı tetikleyici faktörlerle daha da kötüleşebilen nadir bir klinik durumdur. SPS’nin otoimmün, idiyopatik ve paraneoplastik olmak üzere üç varyantı vardır. Paraneoplastik tipi neoplaziler ile ilişkilidir. Paraneoplastik varyant, meme kanseri ve küçük hücreli akciğer kanserli hastalarda bildirilmiştir. Ancak literatürde pankreas kanseri ile ilişkisi bildirilmemiştir. Bu olgu sunumu ile pankreas kanserinin SPS ile ilişkisini ilk olarak gösterdiğimizi düşünmekteyiz.

Keywords

• Stiff person sendromu, paraneoplastik, pankreas kanseri

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