D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi

Abstract

D vitamini kalsiyum ve fosfor metabolizmasını düzenleyen, yağda eriyen vitaminler arasında yer alan ve diğer vitaminlerden farklı olarak vücutta üretilen hormon ve hormon öncüleri olan bir grup steroldür. D vitamininin sadece kemik, böbrek ve bağırsak üzerinde değil, aynı zamanda beyin, prostat, meme, kolon, pankreas, immün hücreler, kaslar, endotel ve miyokard olmak üzere pek çok organ üzerinde de etkisi olduğu belirtilmektedir. D vitamini pankreasta Beta hücreleri üzerinde stokinlerin neden olduğu hücre harabiyetini engeller, insülin salınımını uyarır, kardiyovasküler sistemde köpük hücre oluşumunu ve makrofajların kolesterol alımını inhibe eder, ayrıca vasküler düz kas hücrelerin proliferasyonunu azaltır, lenfositlerden salınan sitokinlerin inhibisyonu ile endotel hücrelerinde adezyon moleküllerinin üretimini baskılayarak ateroskleroz gelişimini engeller. Aynı zamanda vitamin D' nin aktif formu olan 1,25(OH)2D, renin seviyelerini baskılayarak antihipertansif etki gösterir. Vitamin D’nin endokrin ve kardiyovasküler sisteme olan bu etkileri göz önüne alındığında eksikliğinin pek çok hastalığa yol açabileceği düşünülmektedir. Son yıllarda yapılan çalışmalarda D vitamini eksikliğinin insulin direncini, metabolik sendrom riskini artırdığı, obezite, kanser, Tip 1, Tip 2 DM ve hipertansiyon gibi birçok hastalık için risk faktörü olduğu görülmektedir. Çalışma, D vitamini eksikliğinin obezite, diabetes mellitus, hipertansiyon ve kanser arasındaki ilişki üzerine mevcut literatürü gözden geçirmeyi hedeflemektedir.

Keywords

• D vitamini eksikliği
• Obezite
• Diabetes Mellitus
• Hipertansiyon
• Kanser

D Vitaminin Obezite, Diabetes Mellitus, Hipertansiyon ve Kanser İle İlişkisi

Abstract

Vitamin D is a group of sterols that regulate calcium and phosphorus metabolisma are one of the fat-soluble vitamins and among hormones and hormone precursors produced in the
body unlike the other vitamins. Vitamin D is reported to have an effect not only on bone, kidney, and intestine, but also on many organs such as brain, prostate, breast, colon, pancreas,
immune cells, muscles, and including myocardium and endothelium. Vitamin D prevents the damage of cells caused by cytokines in the pancreason Beta cells, stimulates insulin secretion,
inhibits formation of the foam cell in the cardiovascular system and the cholesterol intake of macrophages, and also reduces the proliferation of vascular smooth muscle cells,and inhibits
the development of atherosclerosis by suppressing the production of adhesion molecules in endothelial cells with the inhibition of cytokines released from lymphocytes. At the same
time, 1,25(OH)2D,which is the active form of vitamin D shows an antihypertensive effect by suppressing the levels of renin. Upon taking those effects of vitamin D on endocrine and
cardiovascular systems into account, a lack of it is thought to lead to many health problems. Studies having been conducted in recent years show that vitamin D deficiency increases
insulin resistance and the risk of metabolic syndrome and seems to be a risk factor for many diseases such as obesity, cancer, Type1, Type 2 Diabetes Mellitus (DM) and hypertension.
Our study aims to review existing literature on relationship between vitamin D deficiency and obesity, diabetes mellitus , hypertension and cancer

Keywords

• Vitamin D deficiency
• diabetes mellitus
• hypertension
• cancer

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