DISTRIBUTION OF SELENOPROTEIN W1 (rs3786777) GENOTYPES IN TURKISH PREECLAMPTIC WOMEN

Abstract

Objective: Preeclampsia is characterized by hypertension, proteinuria and edema during pregnancy, It causes. intrauterine growth retardation, premature birth, fetal and maternal mortality. The selenium takes place in the structure of selenoproteins which are mostly showing oxidoreductase activity in human. Some studies were reported that selenoproteins W (SelW) plays an important role as an antioxidant in the developing brain and embryo. SelW expression level in the fetal muscle and heart tissue depends on fetal selenium levels. SelW function is not completely elucidated yet. The purpose of this study was to determine whether common variation in selenoprotein W1 (SEPW1) alters the risk of preeclampsia (PE).

 

Materials and Methods: 82 pregnant women with PE and 85 healthy pregnant women from the same geographic region were included in the study. Allele-specific Polymerase Chain Reaction (ASPCR) analysis was used to identify polymorphism of the SEPW1 gene (rs3786777).

 

Results: Serum lipids, total protein and albumin levels were measured in all cases. We found that fetal weight, total protein and albumin levels significantly decreased in preeclamptic pregnancies compared to healthy pregnant (p=0.001, for each).  Systolic and diastolic blood pressure, body mass index, total cholesterol and triglyceride levels were significantly increased in preeclamptic patients when compared to healthy control group (p=0.001, p=0.001, p=0.001, p=0.05, p=0.01, respectively). The frequencies of the CC, CA and AA genotypes were found as 23 %, 67 % and 10 % in pregnant women with PE and 27 %, 57 % and 16 % in healthy pregnant women, respectively. Our results indicated that the distribution of the SEPW1 genotypes and alleles did not differ significantly among subjects with or without PE (p>0.05).

 

Conclusions: In some study SelW is associated with fetal development, so we thought that its gene distribution may be involved in the occurrence of preeclampsia or its complication. SEPW1 polymorphism did not alter the risk of PE in our population. However, clarification by further studies in larger populations is needed. SEPW1 (rs3786777) polymorphism has no role in etiopathogenesis of preeclamptic Turkish women.

Keywords

• Preeclampsia; Selenoprotein W1 gene; Polymorphism

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