Paclitaxel-Carboplatin based therapy in elderly patients with Non-small Cell Lung Cancer

Abstract

Background: Nonsmall cell lung cancer (NSCLC) is increasingly seen in the elderly population. At the time of diagnosis, more than half of the patients are over 65 years of age.

Method: We retrospectively analyzed our hospital records. NSCLC patients treated with combination either chemotherapy or combination with radiation according to the stage.

Results: The median follow up period was 20 months and 9 (32%) patients died during this period. Patients with stage IV patients had 7.9 months median OS, patients who had locally advanced stage had 19 months median OS. Serum uric acid levels were significantly correlated with overall survival and overall response rates in locally advanced disease (HR 1.01-2.4, P=0.05 and 0.02, respectively).

Conclusion: Our results showed that combination therapy with taxanes and platinums can be effective choice for selected elderly patients and we can use serum uric acid levels as a prognostic factor who had advanced NSCLC.

Keywords

• elderly patients,uric acid

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