EMBRİYO İMPLANTASYONUNUN MOLEKÜLER MEKANİZMASI

Öz

İnsan embriyosunun uterus duvarına implantasyonu, blastosist ve reseptif endometriyum arasındaki karşılıklı etkileşim sonucu gerçekleşir. Fertilizasyondan yaklaşık 6-7 gün sonra implantasyon başlar. İmplantasyonun meydana gelebileceği uygun olgunluk düzeyine ulaşmak için, hem blastosist hem de uterus birbirine paralel olarak farklılaşmalıdır.  Trofoekdoterm (TE) ile uterus yüzeyini kaplayan lüminal epitel (LE) arasındaki etkileşim, implantasyonu başlatır. TE ve LE arasındaki ilk bağlantıda bir dizi hücre-yüzey molekülü rol alır. Bu bileşenlerin rolüne dair kanıtlar tartışmalıdır. Biz de çalışmamızda implantasyon olayının tüm aşamalarında hangi sinyalizasyon ağlarının rol aldığını ve implantasyon esnasında meydana gelen olayların mekanizmalarını moleküler düzeyde literatür bilgisi ışığında derlemeyi amaçladık.

Anahtar Kelimeler

• Embriyonik implantasyon,uterus reseptivitesi,hücre yüzey molekülleri,endometriyal sitokinler

MOLECULAR MECHANISM OF EMBRIONIC IMPLANTATION

Abstract

The implantation of the human embryo into the uterine wall results from the interaction between the blastocyst and the receptive endometrium. Approximately 6-7 days after fertilization, implantation begins. Both the blastocyst and the uterus must be differentiated in parallel to achieve the proper maturity at which implantation can occur. The interaction between trophoecdotherm (TE) and the luminal epithelium (LE) covering the uterine surface initiates implantation. A number of cell-surface molecules are involved in the initial connection between TE and LE. Evidence of the role of these components is controversial. In this study, we aimed to review which signaling networks are involved in all stages of implantation and the mechanisms of events occurring during implantation in the light of the literature.

Keywords

• Embryonic implantation,uterine reseptivity,cell surface molecules,endometrial cytokines

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