Effect of Olmesartan on Left Ventricular Hypertrophy in Hypertensive Patients

Abstract

Objective: Detection of left ventricular hypertrophy (LVH) regression with antihypertensive treatment in hypertensive patients is associated with decreased risk of cardiovascular disease. Angiotensin receptor blockers (ARBs) that were decreased left ventricular hypertophy in hypertensive patients. In this study, we aimed to investigate the effect of olmesartan on LVH in hypertensive patients. Method: In this study we enrolled hypertensive patients whom have LVH. 16 patients received olmesartan 20 mgr/day and 16 patients received atenolol 50 mgr/day. Echocardiography was performed at the begining and in the first and sixth month. Left ventricular mass index (LVMI) were calculated using Devereux Formula. Results: In the olmesartan group, initial left ventricular mass index (LVMI) was 127.7 ± 21.8 g / m2, 124.2 ± 19.7 g / m2 in the first month and 107.3 ± 17.2 g / m2 in the sixth month. The initial LVMI in the atenolol group was 128.7 ± 24.2 g / m2, 128.3 ± 24.2 g / m2 in the first month and 123.1 ± 22.7 g / m2 in the sixth monthThere was no significant difference between LVMI in both groups at baseline and at 1 month. LVMI regressed more in the group receiving olmesartan in the sixth month ( p= 0,034). Conclusion: LVMI regressed significantly in the group receiving olmesartan at the end of the 6th month. The decrease in LVMI in Olmesartan group suggests that ARBs have molecular effect besides blood pressure decrease.

Keywords

• Hypertension,Left ventricle hypertrophy

Hipertansif Hastalarda Olmesartan’ın Sol Ventrikül Hipertrofisi Üzerine Etkisi

Öz

Amaç: Antihipertansif tedavi ile sol ventrikül hipertrofisi (SVH) gerilemesi saptanması kardiyovasküler hastalık riskinde azalma ile ilişkilidir. Angiotensin reseptor blokerleri (ARB) hipertansiyona bağlı SVH’ ni geriletmede etkili ajanlardır. Biz çalışmamızda olmesartan’ın SVH üzerine etkisini araştırmayı amaçladık. Metod: Çalışmamıza SVH olan hipertansif hastaları dahil ettik. Çalışmaya 16 olmesartan 20 mgr/gün ve 16 atenolol 50 mgr/gün alan hasta dahil edildi. Ekokardiyografi tüm hastalara başlangıçta, 1. ve 6. ayda uygulandı. Sol ventrikül kütle indeksi (SVKİ) Devereux formülü ile hesaplandı. Bulgular: Olmesartan grubunda başlangıç SVKİ 127,7 ± 21,8 gr/m2, birinci ayda 124,2 ± 19,7 gr/m2 ve altıncı ayda 107,3 ± 17,2 gr/m2 olarak bulundu. Atenolol grubunda başlangıç SVKİ 128,7 ± 24,2 gr/m2, birinci ayda 128,3 ± 24,2 gr/m2 ve altıncı ayda 123,1 ± 22,7 gr/m2 olarak bulundu. Her iki grup SVKİ değerleri arasında başlangıçta anlamlı fark yoktu. 1. aydaki iki grup SVKİ’ i değerleri arasında anlamlı fark saptanmadı. 6. aydaki SVKİ arasında olmesartan lehine istatistiksel olarak anlamlı fark tespit edildi. ( p= 0,034). Sonuç: İki grup arasında SVKİ’leri 6.ay sonunda olmesartan alan grupta anlamlı olarak daha fazla geriledi. Olmesartan grubundaki SVKİ deki azalmanın kan basıncı düşürmesinin yanında ARB’lerin moleküler etkisi olduğunu düşündürmektedir.

Anahtar Kelimeler

• Hipertansiyon

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