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Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü

Year 2015, Volume: 1 Issue: 2, 42 - 45, 20.06.2015

Derya Güzel

Abstract

Büyüme ve gelişme ile yara iyileşmesi gibi fi zyolojik süreçlerde doku beslenme mekanizmasının doğru çalışması organ
gelişimi ve fonksiyonu için önemlidir. Kanser gibi kontrolsüz ve disfonksiyonel büyüme ile devam eden patolojik süreçlerde
ise damar oluşumunun önlenmesi tedavi açısından önem taşır. Damarlanmanın oluşmasında temel molekül olan; VEGF
mitogenez, anjiyogenez ve endotelyal fonksiyonların düzenlenmesi dahil birçok önemli görev yapar. Bu makale ile; damar
oluşum mekanizmaları, görevli büyüme faktörleri, bu faktörlerin etkileştiği reseptör yapıları ve bu etkileşime neden olan
koşulların belirtilmesi amaçlanmıştır

Keywords

Angiogenesis VEGF VEGFR

References

  • Fong GH. Mechanisms of adaptive angiogenesis of tissue hypoxia. Angiogenesis. 2008; 11: 121-140.
  • Hamilton WJ, Boyd JD, Mossmann HW. Human embryology. Baltimore: Williams & Wilkins. 1962.
  • Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol. 1995; 11: 73–91.
  • Risau W. Mechanisms of angiogenesis. Nature. 1997; 386: 671–674.
  • Djonov V, Baum O, Burri PH. Vascular remodeling by intussusceptive angiogenesis. Cell Tissue Res. 2003; 314: 107-117.
  • Hurz H, Burre PH, Djonov V. Angiogenesis and vascular remodeling by intussusception: from form to function. News Physiol. Sci 2003;18: 65-70.
  • Egginton S, Zhou AL, Brown MD, Hudlicka O. Unorhodox angiogenesis in skelatal muscle. Cardiovasc. Res. 2001; 49: 634-646.
  • Hansen- Smith FM, Hudlicka O, Egginton S. In vivo angiogenesis in adult rat skelatal muscle: early changes in capillary network architecture and ultrastructure. Cell Tissue Res. 1996; 286: 123-136.
  • Liao EC, Zon LI. Conservation of themes in vertebrate blood development. In: Moody SA. Cell Lineage and Fate Determination. San Diego: Academic Press. 1999: 569-582.
  • Hirota K, Semenza GL, Regulation of angiogenesis by hypoxia-inducible factor 1.Critical Reviews in Oncology/Hematology. 2006; 59: 15-26.
  • Buschamannn I, Heil M, Jost M, Schaper W. Influence of inflamatory cytokines on arterigenesis. Microcirculation. 2003; 10: 371-379.
  • Van Royen N, Piek JJ, Buschamannn I, Hoefer I, Voskuil M, Schaper W. Stümaliton of arteriogenesis: a new concept for the treatment of arterial occlusive disease. Cardiovasc Res. 2001; 49: 543-553.
  • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989; 246: 1306–1309.
  • Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989; 246: 1309–1312.
  • Vincenti V, Cassano C, Rocchi M, Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation. 1996; 93: 1493–1495.
  • Ferrara N. Vascular Endothelial Growth Factor: Basic Science and Clinical Progress. Endocrine Reviews. 2004; 25(4): 581–611.
  • Vaisman N, Gospodarowicz D, Neufeld G. Characterization of the receptors for vascular endothelial growth factor. J Biol Chem. 1990; 265: 19461– 19466.
  • Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest. 1992; 89: 244–253.
  • Shen H, Clauss M, Ryan J, Schmidt AM, Tijburg P, Borden L, Connolly D, Stern D, Kao J. Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood. 1993; 81: 2767–2773.
  • De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992; 255: 989–991.
  • Gerber HP, Condorelli F, Park J, Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem. 1997; 272: 23659–23667.
  • Matsumoto T, Claesson-Welsh L. VEGF receptor signal transduction. Trends Biochem Sci. 2003; 28(9): 488-494.
  • Ferrara N, Gerber HP; Claesson-Welsh L. The biology of VEGF and its receptors. Nat Med. 2003; 9: 669-676.
  • Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time- dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci USA. 1996; 93: 14765–14770.
  • Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, Pan YC, Olander JV, Connolly DT, Stern D. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med. 1990; 172: 1535–1545.
  • Broxmeyer HE, Cooper S, Li ZH, Lu L, Song HY, Kwon BS, Warren RE, Donner DB Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor. Int J Hematol. 1995; 62: 203–215.
  • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983; 219: 983–985.
  • Ku DD, Zaleski JK, Liu S, Brock TA. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am J Physiol. 1993; 265: H586–H592
  • 149 Yang R, Thomas GR, Bunting S, Ko A. Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J Cardiovasc Pharmacol. 1996; 27: 838–844.
  • Frank S, Hubner G, Breier G, Longaker MT, Greenhalgh DG, Werner S. Regulation of VEGF expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem. 1995; 270: 12607– 12613.
  • Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor in fibroblastic and epithelial cells. J Biol Chem. 1994; 269: 6271–6274.
  • Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem. 1996; 271: 29483–29488.
  • Ben-Av P, Crofford LJ, Wilder RL, Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts. FEBS Lett. 1995; 372: 83–87.
  • Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem. 1996; 271:736–741.
  • Soh EY, Sobhi SA, Wong MG, Meng YG, Siperstein AE, Clark OH, Duh QY Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines. Surgery. 1996; 120: 944–947.
  • Shifren JL, Mesiano S, Taylor RN, Ferrara N, Jaffe RB. Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells. J Clin Endocrinol Metab. 1998; 83: 1342–1347.

Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü

Year 2015, Volume: 1 Issue: 2, 42 - 45, 20.06.2015

Derya Güzel

Abstract

Tıp Fakültesi Dekanlığı, Korucuk Mahallesi, Konuralp Bulvarı,No:81/1 Korucuk Kampüsü, Adapazarı/SakaryaTel: 0 (264) 295 66 30 Fax: 0 (264) 295 66 29 ankara.medicine@gmail.com

Keywords

Angiogenesis VEGF VEGFR

References

  • Fong GH. Mechanisms of adaptive angiogenesis of tissue hypoxia. Angiogenesis. 2008; 11: 121-140.
  • Hamilton WJ, Boyd JD, Mossmann HW. Human embryology. Baltimore: Williams & Wilkins. 1962.
  • Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol. 1995; 11: 73–91.
  • Risau W. Mechanisms of angiogenesis. Nature. 1997; 386: 671–674.
  • Djonov V, Baum O, Burri PH. Vascular remodeling by intussusceptive angiogenesis. Cell Tissue Res. 2003; 314: 107-117.
  • Hurz H, Burre PH, Djonov V. Angiogenesis and vascular remodeling by intussusception: from form to function. News Physiol. Sci 2003;18: 65-70.
  • Egginton S, Zhou AL, Brown MD, Hudlicka O. Unorhodox angiogenesis in skelatal muscle. Cardiovasc. Res. 2001; 49: 634-646.
  • Hansen- Smith FM, Hudlicka O, Egginton S. In vivo angiogenesis in adult rat skelatal muscle: early changes in capillary network architecture and ultrastructure. Cell Tissue Res. 1996; 286: 123-136.
  • Liao EC, Zon LI. Conservation of themes in vertebrate blood development. In: Moody SA. Cell Lineage and Fate Determination. San Diego: Academic Press. 1999: 569-582.
  • Hirota K, Semenza GL, Regulation of angiogenesis by hypoxia-inducible factor 1.Critical Reviews in Oncology/Hematology. 2006; 59: 15-26.
  • Buschamannn I, Heil M, Jost M, Schaper W. Influence of inflamatory cytokines on arterigenesis. Microcirculation. 2003; 10: 371-379.
  • Van Royen N, Piek JJ, Buschamannn I, Hoefer I, Voskuil M, Schaper W. Stümaliton of arteriogenesis: a new concept for the treatment of arterial occlusive disease. Cardiovasc Res. 2001; 49: 543-553.
  • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989; 246: 1306–1309.
  • Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989; 246: 1309–1312.
  • Vincenti V, Cassano C, Rocchi M, Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation. 1996; 93: 1493–1495.
  • Ferrara N. Vascular Endothelial Growth Factor: Basic Science and Clinical Progress. Endocrine Reviews. 2004; 25(4): 581–611.
  • Vaisman N, Gospodarowicz D, Neufeld G. Characterization of the receptors for vascular endothelial growth factor. J Biol Chem. 1990; 265: 19461– 19466.
  • Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest. 1992; 89: 244–253.
  • Shen H, Clauss M, Ryan J, Schmidt AM, Tijburg P, Borden L, Connolly D, Stern D, Kao J. Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood. 1993; 81: 2767–2773.
  • De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992; 255: 989–991.
  • Gerber HP, Condorelli F, Park J, Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem. 1997; 272: 23659–23667.
  • Matsumoto T, Claesson-Welsh L. VEGF receptor signal transduction. Trends Biochem Sci. 2003; 28(9): 488-494.
  • Ferrara N, Gerber HP; Claesson-Welsh L. The biology of VEGF and its receptors. Nat Med. 2003; 9: 669-676.
  • Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time- dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci USA. 1996; 93: 14765–14770.
  • Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, Pan YC, Olander JV, Connolly DT, Stern D. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med. 1990; 172: 1535–1545.
  • Broxmeyer HE, Cooper S, Li ZH, Lu L, Song HY, Kwon BS, Warren RE, Donner DB Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor. Int J Hematol. 1995; 62: 203–215.
  • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983; 219: 983–985.
  • Ku DD, Zaleski JK, Liu S, Brock TA. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. Am J Physiol. 1993; 265: H586–H592
  • 149 Yang R, Thomas GR, Bunting S, Ko A. Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J Cardiovasc Pharmacol. 1996; 27: 838–844.
  • Frank S, Hubner G, Breier G, Longaker MT, Greenhalgh DG, Werner S. Regulation of VEGF expression in cultured keratinocytes. Implications for normal and impaired wound healing. J Biol Chem. 1995; 270: 12607– 12613.
  • Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor in fibroblastic and epithelial cells. J Biol Chem. 1994; 269: 6271–6274.
  • Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem. 1996; 271: 29483–29488.
  • Ben-Av P, Crofford LJ, Wilder RL, Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts. FEBS Lett. 1995; 372: 83–87.
  • Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem. 1996; 271:736–741.
  • Soh EY, Sobhi SA, Wong MG, Meng YG, Siperstein AE, Clark OH, Duh QY Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines. Surgery. 1996; 120: 944–947.
  • Shifren JL, Mesiano S, Taylor RN, Ferrara N, Jaffe RB. Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells. J Clin Endocrinol Metab. 1998; 83: 1342–1347.
There are 36 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Derya Güzel This is me

Publication Date June 20, 2015
Submission Date June 20, 2015
Published in Issue Year 2015 Volume: 1 Issue: 2

Cite

APA Güzel, D. (2015). Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü. Journal of Human Rhythm, 1(2), 42-45.
AMA Güzel D. Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü. Journal of Human Rhythm. June 2015;1(2):42-45.
Chicago Güzel, Derya. “Damar Oluşum Fizyolojisi Ve Vasküler Endotelyal Büyüme Faktörü”. Journal of Human Rhythm 1, no. 2 (June 2015): 42-45.
EndNote Güzel D (June 1, 2015) Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü. Journal of Human Rhythm 1 2 42–45.
IEEE D. Güzel, “Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü”, Journal of Human Rhythm, vol. 1, no. 2, pp. 42–45, 2015.
ISNAD Güzel, Derya. “Damar Oluşum Fizyolojisi Ve Vasküler Endotelyal Büyüme Faktörü”. Journal of Human Rhythm 1/2 (June 2015), 42-45.
JAMA Güzel D. Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü. Journal of Human Rhythm. 2015;1:42–45.
MLA Güzel, Derya. “Damar Oluşum Fizyolojisi Ve Vasküler Endotelyal Büyüme Faktörü”. Journal of Human Rhythm, vol. 1, no. 2, 2015, pp. 42-45.
Vancouver Güzel D. Damar Oluşum Fizyolojisi ve Vasküler Endotelyal Büyüme Faktörü. Journal of Human Rhythm. 2015;1(2):42-5.