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BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA

Year 2017, Volume: 3 Issue: 1, 50 - 55, 30.03.2017

Halil Komek Hasan Morcalı Serdar Altındağ Canan Can Timur Ugur

Abstract

Background: There have been different biodistribution
of Ga-68 PMSA in normal organs.

Methods: SUVmax and SUVmean values was evuluated
 of 66 patients who underwent Ga-68 PSMA,
without radical prostatectomy, relapse in the prostate gland, extensive
metastasis, or metastasis in the target.

Results: The SUVmax and SUVmean values of the
patients included in the study were determined to range from high to low as
bladder, kidney, submandibular gland, parotid salivary gland, duodenum 3rd
part, jejunum, spleen, liver and lachrymal gland. The highest uptake was
observed in the bladder, kidneys and salivary gland.







Conclusions: High PSMA expressions were observed
in the kidney, salivary glands and duodenum 3rd part, medium PSMA
expressions were observed in the liver and lachrymal glands, low PSMA
expressions were observed in normal prostate tissue, stomach, ileum and
pancreas and no PSMA expression was observed in cerebral and cerebellar
cortexes. The bladder should be emptied before examination and reporting and
the proximal small bowel should be examined more carefully as it can show
higher PSMA expression. 

Keywords

Prostate Cancer Ga-68 PMSA Biodistribution

References

  • 1. Silver DA, Pellicer I, Fair WR et al (1997) Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res 3:81–85
  • 2. Sweat SD, Pacelli A, Murphy GP, Bostwick DG. Prostate-specific membrane antigen expression is greatest in prostate adenocarcino ma and lymph node metastases. Urology 1998;52(4):637–40.
  • 3. Mannweiler S, Amersdorfer P, Trajanoski S, Terrett JA, King D,Mehes G. Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. Pathol Oncol Res 2009;15(2):167–72.
  • 4. Schuhmacher J, Maier-Borst W. A new 68Ge/68Ga radioisotope generator system for production of 68Ga in dilute HCl. Int J Appl Radiat Isot 1981;32:31–6.
  • 5. Bander NH. Technology insight: monoclonal antibody imaging of prostate cancer. Nat Clin Pract Urol 2006;3(4):216–25
  • 6. Afshar-Oromieh A, Haberkorn U, Eder M, Eisenhut M, Zechmann C. [(68)Ga]Gallium-labeled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with (18)F-FECH. Eur J Nucl Med Mol Imaging 2012;39(6):1085–6.
  • 7. Eder M, Schafer M, Bauder-Wüst U, Hull WE, Wangler C, Mier W, et al. (68)Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PEt imaging. Bioconjug Chem 2012;23:688-97
  • 8. Ghosh A, Heston WD. Tumor target prostate specific membraneantigen (PSMA) and its regulation in prostate cancer. J Cell Bio-chem 2004;91:528–39.
  • 9. Human protein atlas. FOLH1. http://www.proteinatlas.org/ ENSG00000086205/normal.
  • 10. Israeli R. S., Powell C.T., Corr J.G., Fair W.R., and Heston W.D.W.. Expression oft he prostate-specific membrane antigen. Cancer Res.,54: 1807-1811,1994.
  • 11. Troyer J.K., Beckett M.L., and Wright G.L., Jr. Detection and characterization oft he prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int. J. Cancer, 62:552-558,1995.
  • 12. Pinto J., Suffoletto B., Berzin T., Qaio C., Lin S., Tong W., and Heston W.D.W.. İdentification of a membrane-bound pteroyl poly gamma-glutamyl carboxypeptidase (folate hydrolase) that is highly expressed in human prostatic carcinoma cells (Abstract 2862). FASEB J., 10:A496,1996.

Year 2017, Volume: 3 Issue: 1, 50 - 55, 30.03.2017

Halil Komek Hasan Morcalı Serdar Altındağ Canan Can Timur Ugur

Abstract

References

  • 1. Silver DA, Pellicer I, Fair WR et al (1997) Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res 3:81–85
  • 2. Sweat SD, Pacelli A, Murphy GP, Bostwick DG. Prostate-specific membrane antigen expression is greatest in prostate adenocarcino ma and lymph node metastases. Urology 1998;52(4):637–40.
  • 3. Mannweiler S, Amersdorfer P, Trajanoski S, Terrett JA, King D,Mehes G. Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. Pathol Oncol Res 2009;15(2):167–72.
  • 4. Schuhmacher J, Maier-Borst W. A new 68Ge/68Ga radioisotope generator system for production of 68Ga in dilute HCl. Int J Appl Radiat Isot 1981;32:31–6.
  • 5. Bander NH. Technology insight: monoclonal antibody imaging of prostate cancer. Nat Clin Pract Urol 2006;3(4):216–25
  • 6. Afshar-Oromieh A, Haberkorn U, Eder M, Eisenhut M, Zechmann C. [(68)Ga]Gallium-labeled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with (18)F-FECH. Eur J Nucl Med Mol Imaging 2012;39(6):1085–6.
  • 7. Eder M, Schafer M, Bauder-Wüst U, Hull WE, Wangler C, Mier W, et al. (68)Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PEt imaging. Bioconjug Chem 2012;23:688-97
  • 8. Ghosh A, Heston WD. Tumor target prostate specific membraneantigen (PSMA) and its regulation in prostate cancer. J Cell Bio-chem 2004;91:528–39.
  • 9. Human protein atlas. FOLH1. http://www.proteinatlas.org/ ENSG00000086205/normal.
  • 10. Israeli R. S., Powell C.T., Corr J.G., Fair W.R., and Heston W.D.W.. Expression oft he prostate-specific membrane antigen. Cancer Res.,54: 1807-1811,1994.
  • 11. Troyer J.K., Beckett M.L., and Wright G.L., Jr. Detection and characterization oft he prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int. J. Cancer, 62:552-558,1995.
  • 12. Pinto J., Suffoletto B., Berzin T., Qaio C., Lin S., Tong W., and Heston W.D.W.. İdentification of a membrane-bound pteroyl poly gamma-glutamyl carboxypeptidase (folate hydrolase) that is highly expressed in human prostatic carcinoma cells (Abstract 2862). FASEB J., 10:A496,1996.
There are 12 citations in total.

Details

Journal Section Articles
Authors

Halil Komek This is me

Hasan Morcalı This is me

Serdar Altındağ This is me

Canan Can This is me

Timur Ugur This is me

Publication Date March 30, 2017
Submission Date March 31, 2017
Acceptance Date March 22, 2017
Published in Issue Year 2017 Volume: 3 Issue: 1

Cite

APA Komek, H., Morcalı, H., Altındağ, S., Can, C., et al. (2017). BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA. Journal of Human Rhythm, 3(1), 50-55.
AMA Komek H, Morcalı H, Altındağ S, Can C, Ugur T. BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA. Journal of Human Rhythm. March 2017;3(1):50-55.
Chicago Komek, Halil, Hasan Morcalı, Serdar Altındağ, Canan Can, and Timur Ugur. “BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA”. Journal of Human Rhythm 3, no. 1 (March 2017): 50-55.
EndNote Komek H, Morcalı H, Altındağ S, Can C, Ugur T (March 1, 2017) BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA. Journal of Human Rhythm 3 1 50–55.
IEEE H. Komek, H. Morcalı, S. Altındağ, C. Can, and T. Ugur, “BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA”, Journal of Human Rhythm, vol. 3, no. 1, pp. 50–55, 2017.
ISNAD Komek, Halil et al. “BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA”. Journal of Human Rhythm 3/1 (March 2017), 50-55.
JAMA Komek H, Morcalı H, Altındağ S, Can C, Ugur T. BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA. Journal of Human Rhythm. 2017;3:50–55.
MLA Komek, Halil et al. “BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA”. Journal of Human Rhythm, vol. 3, no. 1, 2017, pp. 50-55.
Vancouver Komek H, Morcalı H, Altındağ S, Can C, Ugur T. BIODISTRIBUTION OF Ga 68 PSMA IN NORMAL ORGANS OF PATIENTS WITH PROSTATE CARCINOMA. Journal of Human Rhythm. 2017;3(1):50-5.