IS THERE A RELATIONSHIP BETWEEN SELENOPROTEIN P1 (SEPP1) GENE POLYMORPHISM AND GESTATIONAL DIABETES MELLITUS IN TURKISH WOMEN

Year 2017, Volume: 3 Issue: 1, 56 - 61, 30.03.2017

Ayşe Yücel Fatma Behice Cinemre Hakan Cinemre M. Aytaç Yüksel Abdullah Tüten Nevin Yılmaz Birsen Aydemir

Abstract

Objective: Diabetes Mellitus (DM) is
a complex disease caused by a combination of genetic and environmental factors.
Selenoprotein P (SeP) appears to play a key role in the etiopathogenesis of DM.
Recently, it has been demonstrated that SeP played an important role in
glucose metabolism and the regulation of insulin sensitivity as a new
hepatokine. The purpose of this study was to
determine whether common variations in selenoprotein P1 (SEPP1) alter the risk
of Gestational Diabetes Mellitus (GDM).

Materials and Methods: 72 pregnant women with GDM and 64 healthy pregnant
women from the same geographic region were included in the study.
Allele-specific Polymerase Chain Reaction (ASPCR) analysis was used to identify
polymorphisms of the SEPP1 gene
(rs3877899).

Results: We found that fasting glucose, insulin, HOMA-IR, HbA1c, total
cholesterol levels and weight of fetus were higher in gestational diabetic
pregnants compared group to healthy pregnant women group. The frequencies of
the AA, GA and GG genotypes were found as 28 %, 43 % and 29 % in pregnant women
with GDM and 24 %, 50 % and 26 % in healthy pregnant women, respectively. Our
results indicated that the distribution of the SePP1 genotypes and alleles did
not differ significantly among subjects with or without GDM (p>0.05).

Conclusions: Although SeP plays a key role in glucose metabolism
and the regulation of insulin sensitivity, the SEPP1 polymorphism did not
changed occurrence of GDM in our population. Different mechanisms may be
involved in etiopathogenesis of GDM. However, it should be clarified with
further studies in larger populations. SEPP1 (rs3877899) polymorphism has no
role in development of gestational diabetes in Turkish women.

Keywords

Gestational diabetes mellitus; Selenoprotein P gene; Polymorphism

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