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Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering

Year 2021, Volume: 3 Issue: 2, 46 - 57, 31.12.2021

Merve Nur Soykan Tayfun Şengel Aliakbar Ebrahimi Murat Kaya Burcugül Altuğ Tasa Hamed Ghorbanpoor Onur Uysal Ayla Eker Sarıboyacı Huseyin Avci

https://doi.org/10.51934/jomit.1016838
Cited By: 1

Abstract

The complex process behind the brain topology, which has been extensively studied for the last ten years, is still unclear. Therefore, neural tissue engineering studies are needed to better understand cortical folds. With the development of 4-dimensional (4D) bioprinters using cell-loaded smart materials, a promising path has been opened in the mimicry of the neural tissue. In our study, we review the usage areas of 4D printers, which have been developing in recent years, in modelling brain tissue. As a result of development of smart materials printed with 3-dimensional (3D) printers caused emerging of 4D printers, rapidly. Smart materials can change their properties based on physical, chemical and biological stimuli, and this change can be a reversible process. Cell-loaded printed smart materials should have little effect on cell viability of both the incoming stimulus and the physical change. It is also important that the material used is non-toxic and the solvent is suitable for cell viability. On the other hand, hydrogels are frequently studied to mimic the complex neural network of neural tissue. Agents that affect the crosslinking or degree of crosslinking of hydrogels can be easily controlled and changed. In addition, studies with neural stem cells have shown that hydrogels have a supportive effect on the proliferation and maturation of neural stem cells. Since the folding time, strength and location of smart materials cannot be known precisely, it can be an advantage of 4D bioprinters as it can be controlled and studied whether the results of the stress on the cells in this region will affect other cells. It is an ideal methodology to study the effect of cortical folding on neural stem cells, especially thanks to the ease of experimental manipulations provided by 4D bioprinters. It is expected that 4D bioprinters will be adopted and rapid developments will occur in the multidisciplinary field of tissue engineering of brain tissue in the near coming years.

Keywords

Neural-tissue engineering Neural modeling 4D Printer Smart biomaterial Shape memory

Supporting Institution

Turkish Scientific and Technological Council (TÜBİTAK) and Eskisehir Osmangazi University (Scientific Research Foundation)

Thanks

We gratefully acknowledge Turkish Scientific and Technological Council (TÜBİTAK) and Eskisehir Osmangazi University (Scientific Research Foundation) for their support.

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Gelişmiş Modellemede Yeni Alan Dört Boyutlu Baskı Teknolojisi ve Beyin Doku Mühendisliğinde Uygulamaları

Year 2021, Volume: 3 Issue: 2, 46 - 57, 31.12.2021

Merve Nur Soykan Tayfun Şengel Aliakbar Ebrahimi Murat Kaya Burcugül Altuğ Tasa Hamed Ghorbanpoor Onur Uysal Ayla Eker Sarıboyacı Huseyin Avci

https://doi.org/10.51934/jomit.1016838
Cited By: 1

Abstract

Son on yıldır kapsamlı çalışmalar yapılan beyin topolojisinin arkasında yatan süreç henüz belirsizdir. Kortikal katlanmaların daha iyi anlaşılabilmesi için nöral doku mühendisliği çalışmalarına ihtiyaç vardır. Hücre yüklü akıllı malzemelerin kullanıldığı 4 boyutlu (4B) biyoyazıcıların gelişmesi ile nöral dokunun mimik edilmesinde umut verici bir yol açılmıştır. Çalışmamızda son yıllarda gelişmekte olan 4B yazıcıların beyin dokusunun modellenmesinde kullanım alanlarını gözden geçirmekteyiz. 3 boyutlu (3B) yazıcılar ile basılan akıllı malzemelerin gelişmesiyle 4B yazıcılar ortaya çıkmıştır. Akıllı malzemeler fiziksel, kimyasal ve biyolojik uyaranlara dayalı olarak özelliklerini değiştirebilirler ve bu değişiklik geri dönüşümlü bir süreçtir. Hücre yüklü olarak basılan akıllı malzemeler hem gelen uyarıcının hem de fiziksel değişimin hücre canlılığı üzerinde çok az bir etki yaratması gerekir. Ayrıca kullanılan malzemenin toksik olmaması ve çözücünü hücre canlılığına uygun olması da önemlidir. Nöral dokunun karmaşık sinir ağının mimik edilebilmesi için hidrojeller ile sıklıkla çalışılmaktadır. Hidrojellerin çapraz bağlanmasını veya çapraz bağlanma derecesini etkileyen ajanlar kolaylıkla kontrol edilebilir ve değiştirilebilir. Ayrıca nöral kök hücreler ile yapılan çalışmalarda hidrojellerin nöral kök hücrelerin proliferasyon ve olgunlaşması üzerinde destekleyici bir etkiye sahip olduğu gösterilmiştir. Akıllı malzemelerin katlanma zamanı, kuvveti ve yeri kesin olarak bilinemediği için bu bölgede bulunan hücreler üzerindeki stresin sonuçlarının diğer hücreleri etkileyip etkilemeyeceğinin ön görülmesi zorluğu 4B biyoyazıcıların bir avantajı olarak karşımıza çıkma ihtimalini göstermektedir. Burada özellikle 4B biyoyazıcıların sağladığı deneysel manipülasyonların kolaylığı sayesinde kortikal katlanmanın nöral kök hücreler üzerine etkisini incelemek için ideal bir metodolojidir. Önümüzdeki yakın yıllarda multidisipliner olan beyin doku mühendisliği alanında 4B biyoyazıcıların benimseneceği ve hızlı gelişmelerin olacağını düşünmekteyiz.

Son on yıldır kapsamlı çalışmalar yapılan beyin topolojisinin arkasında yatan süreç henüz belirsizdir. Kortikal katlanmaların daha iyi anlaşılabilmesi için nöral doku mühendisliği çalışmalarına ihtiyaç vardır. Hücre yüklü akıllı malzemelerin kullanıldığı 4 boyutlu (4B) biyoyazıcıların gelişmesi ile nöral dokunun mimik edilmesinde umut verici bir yol açılmıştır. Çalışmamızda son yıllarda gelişmekte olan 4B yazıcıların beyin dokusunun modellenmesinde kullanım alanlarını gözden geçirmekteyiz. 3 boyutlu (3B) yazıcılar ile basılan akıllı malzemelerin gelişmesiyle 4B yazıcılar ortaya çıkmıştır. Akıllı malzemeler fiziksel, kimyasal ve biyolojik uyaranlara dayalı olarak özelliklerini değiştirebilirler ve bu değişiklik geri dönüşümlü bir süreçtir. Hücre yüklü olarak basılan akıllı malzemeler hem gelen uyarıcının hem de fiziksel değişimin hücre canlılığı üzerinde çok az bir etki yaratması gerekir. Ayrıca kullanılan malzemenin toksik olmaması ve çözücünü hücre canlılığına uygun olması da önemlidir. Nöral dokunun karmaşık sinir ağının mimik edilebilmesi için hidrojeller ile sıklıkla çalışılmaktadır. Hidrojellerin çapraz bağlanmasını veya çapraz bağlanma derecesini etkileyen ajanlar kolaylıkla kontrol edilebilir ve değiştirilebilir. Ayrıca nöral kök hücreler ile yapılan çalışmalarda hidrojellerin nöral kök hücrelerin proliferasyon ve olgunlaşması üzerinde destekleyici bir etkiye sahip olduğu gösterilmiştir. Akıllı malzemelerin katlanma zamanı, kuvveti ve yeri kesin olarak bilinemediği için bu bölgede bulunan hücreler üzerindeki stresin sonuçlarının diğer hücreleri etkileyip etkilemeyeceğinin ön görülmesi zorluğu 4B biyoyazıcıların bir avantajı olarak karşımıza çıkma ihtimalini göstermektedir. Burada özellikle 4B biyoyazıcıların sağladığı deneysel manipülasyonların kolaylığı sayesinde kortikal katlanmanın nöral kök hücreler üzerine etkisini incelemek için ideal bir metodolojidir. Önümüzdeki yakın yıllarda multidisipliner olan beyin doku mühendisliği alanında 4B biyoyazıcıların benimseneceği ve hızlı gelişmelerin olacağını düşünmekteyiz

Keywords

Nöral doku mühendisliği Nöral modelleme 4B yazıcı Akıllı biyomalzeme Şekil hafızası

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There are 70 citations in total.

Details

Primary Language English
Subjects Tissue Engineering, Biomaterial
Journal Section Review
Authors

Merve Nur Soykan 0000-0003-1231-9791

Tayfun Şengel 0000-0002-1162-6979

Aliakbar Ebrahimi 0000-0001-6437-7796

Murat Kaya 0000-0002-4277-6304

Burcugül Altuğ Tasa 0000-0003-4460-8467

Hamed Ghorbanpoor 0000-0002-2665-8172

Onur Uysal 0000-0001-6800-5607

Ayla Eker Sarıboyacı 0000-0003-4536-9859

Huseyin Avci 0000-0002-2475-1963

Publication Date December 31, 2021
Published in Issue Year 2021 Volume: 3 Issue: 2

Cite

APA Soykan, M. N., Şengel, T., Ebrahimi, A., Kaya, M., et al. (2021). Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering. Journal of Medical Innovation and Technology, 3(2), 46-57. https://doi.org/10.51934/jomit.1016838
AMA Soykan MN, Şengel T, Ebrahimi A, Kaya M, Altuğ Tasa B, Ghorbanpoor H, Uysal O, Eker Sarıboyacı A, Avci H. Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering. Journal of Medical Innovation and Technology. December 2021;3(2):46-57. doi:10.51934/jomit.1016838
Chicago Soykan, Merve Nur, Tayfun Şengel, Aliakbar Ebrahimi, Murat Kaya, Burcugül Altuğ Tasa, Hamed Ghorbanpoor, Onur Uysal, Ayla Eker Sarıboyacı, and Huseyin Avci. “Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering”. Journal of Medical Innovation and Technology 3, no. 2 (December 2021): 46-57. https://doi.org/10.51934/jomit.1016838.
EndNote Soykan MN, Şengel T, Ebrahimi A, Kaya M, Altuğ Tasa B, Ghorbanpoor H, Uysal O, Eker Sarıboyacı A, Avci H (December 1, 2021) Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering. Journal of Medical Innovation and Technology 3 2 46–57.
IEEE M. N. Soykan, “Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering”, Journal of Medical Innovation and Technology, vol. 3, no. 2, pp. 46–57, 2021, doi: 10.51934/jomit.1016838.
ISNAD Soykan, Merve Nur et al. “Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering”. Journal of Medical Innovation and Technology 3/2 (December 2021), 46-57. https://doi.org/10.51934/jomit.1016838.
JAMA Soykan MN, Şengel T, Ebrahimi A, Kaya M, Altuğ Tasa B, Ghorbanpoor H, Uysal O, Eker Sarıboyacı A, Avci H. Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering. Journal of Medical Innovation and Technology. 2021;3:46–57.
MLA Soykan, Merve Nur et al. “Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering”. Journal of Medical Innovation and Technology, vol. 3, no. 2, 2021, pp. 46-57, doi:10.51934/jomit.1016838.
Vancouver Soykan MN, Şengel T, Ebrahimi A, Kaya M, Altuğ Tasa B, Ghorbanpoor H, Uysal O, Eker Sarıboyacı A, Avci H. Four-Dimensional Printing Technology at the Frontier of Advanced Modeling and Applications in Brain Tissue Engineering. Journal of Medical Innovation and Technology. 2021;3(2):46-57.

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Recent Advances in Brain Organoid Technology for Human Brain Research
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https://doi.org/10.1021/acsami.2c17467
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