Yaşlı hastalarda SGLT2 inhibitörü kullanımı: laboratuvar değerlendirilmesi

Year 2022, , 142 - 146, 26.09.2022

Enes Seyda Şahiner , Oğuzhan Zengin

https://doi.org/10.47582/jompac.1143184

Abstract

Amaç: Bu çalışmada Tip-2 Diabetes mellitus (T2DM) ile takipli, empagliflozin veya dapagliflozin kullanan 65 yaş üzeri bireylerde sodyum glukoz kotrasporter 2 (SGLT2) inhibitorü kullanımına bağlı laboratuar parametrelerinde ortaya çıkan sonuçları incelemeyi amaçladık.
Gereç ve Yöntem: 65 yaş üzeri T2DM ile takipli mevcut tedavisine empagliflozin (günde bir kez 10 mg) veya dapagliflozin (günde bir kez 10 mg) eklenmiş 140 hasta iki gruba ayrıldı. Tedavi başlangıcında ve tedavinin 24. haftasındaki laboratuar sonuçları, ilaca bağlı yan etkiler kaydedildi. Çalışma retrospektif olarak tasarlandı.
Bulgular: Her iki grupta da anlamlı açlık kan şekeri ve HbA1c düşüşleri gözlendi. Dapagliflozin grubunda lipid parametrelerinde anlamlı düşüş görüldü. Empagliflozin grubunda fosfor değerlerinde yükselme saptandı. Her iki grupta ise hemoglobin ve kalsiyum değerlerinde anlamlı artış meydana geldi. Toplam yan etkiler açısından anlamlı farklılık saptanmadı..
Sonuç: Kan şekeri regülasyonu dışında birçok olumlu etkileri olan ve yeni etki mekanizmaları keşfedilmeye devam edilen SGLT2 inhibitörleri uygun hasta gruplarında öncelikle tercih edilebilecek preperatlar olduğunu düşünüyoruz.

Keywords

SGLT2 inhibitörleri, yaşlı hastalar, empagliflozin, dapagliflozin, diabetes mellitus

Laboratory changes in older patients using SGLT2 inhibitors

Abstract

Aim: In this study, we aimed to investigate the results of laboratory parameters related to the use of sodium glucose cotransporter 2 (SGLT2) inhibitors in individuals over 65 years of age who were using empagliflozin or dapagliflozin for the treatment of type 2 diabetes mellitus (T2DM).
Material and Method: A total of 140 patients over 65 years of age who had empagliflozin (10 mg once daily) or dapagliflozin (10 mg once daily) added to their current treatment for T2DM were divided into two groups. Laboratory results at the beginning of treatment and at the 24th week of treatment and drug-related adverse events were noted. The study was retrospectively designed.
Results: Significant decreases in fasting blood glucose and HbA1c were observed in both groups. There was a significant decrease in lipid parameters in the dapagliflozin group. Phosphorus values were elevated in the empagliflozin group. In both groups, there was a significant increase in hemoglobin and calcium values. There was no significant difference in terms of adverse events.
Conclusion: We think that SGLT2 inhibitors, which have many positive effects other than blood sugar regulation with new mechanisms of action that continue to be discovered, can be administered as the primary treatment for appropriate patient groups.

Keywords

SGLT2 inhibitors, older patients, empagliflozin, dapagliflozin, diabetes mellitus

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