Delta nötrofil indeksinin aksiller metastazları belirlemede tanısal değeri

Year 2022, , 216 - 220, 26.09.2022

Ertugrul Gazi Alkurt , Mehmet Berksun Tutan

https://doi.org/10.47582/jompac.1162371

Abstract

Amaç: İnflamatuar koşullarda periferik kandaki olgunlaşmamış granülositlerin (IG) yüzdesini gösteren delta nötrofil indeksi(DNI) artan kemik iliği aktivasyonunun bir göstergesi olarak kullanılabilir.Bu çalışmanın amacı meme kanseri prognozunda önemli rol oynayan aksiller lenf nodu metastazını klinik ve radyolojik tespitinden önce IG sayısı ve DNI ile belirlemektir.
Gereç ve Yöntem: Meme kanseri tanısı alıp opere edilen ve aksiller lenf nodu diseksiyonu yapılmış hastalar tarandı ve 127 hasta çalışmaya dahil edildi. Hastaların yaşı, cinsiyeti, operasyon süresi, hastanede yatış süreleri, immatür granülosit (IG) yüzdeleri (IG#) ve aksiller lenf nodu patoloji sonuçları retrospektif olarak arşiv sisteminden tarandı.
Bulgular: DNI VE IG lenf nodu metastazı olan grupta istatiksel olarak daha yüksekti. IG# açısından inceleme yapıldığında lenf nodu reaktif olan grubun ortalaması 0,02±0,02 iken metastatik grubun ortalaması 0,04±0,05 bulundu, istatistiki anlamlı farklılık gösterecek şekilde yüksekti (p<0,001). Hastalar arasında metastazın ayrımı IG#’sı için %40 sensitivite ve %86,1 spesifiteyle 0,035 (OR 4,133, CI%95 0,589-0,777, p<0,001) değerleri cut-off olarak bulunmuştur.
Sonuç: DNI ve IG sayısı, meme kanserinin aksiller metastazını saptamada yüksek duyarlılık ve özgüllüğe sahip yeni öngörücü belirteçler olabilir.

Keywords

Meme kanseri, aksiller lenf nodu metastazı, delta nötrofil indeks, immatur granülosit

Diagnostic value of delta neutrophil index in determining axillary metastases in breast cancer

Abstract

Aim: The delta neutrophil index (DNI), which shows the percentage of immature granulocytes (IG) in peripheral blood in inflammatory conditions, is an indicator of increased bone marrow activation. Its ability to predict prognosis has been demonstrated in many cancer studies. This study aims to investigate the value of DNI in predicting axillary metastases in breast cancer.
Material and Method: Patients diagnosed with breast cancer and operated on axillary lymph node dissection were screened and 127 patients were included in the study. The patient’s age, gender, operation time, length of hospital stay, immature granulocyte (IG) percentages (IG#), and axillary lymph node pathology results were retrospectively scanned from the archive system.
Results: DNI and IG were statistically higher in the group with lymph node metastasis. When examined for IG#, the mean of the group with reactive lymph nodes was 0.02±0.02, while the mean of the metastatic group was 0.04±0.05. This statistically significant difference was high (p<0.001). Cut-off values of 0.035 (OR 4.133, CI 95% 0.589-0.777, p<0.001) were found with 40% sensitivity and 86.1% specificity for the differentiation IG# of metastasis among patients.
Conclusion: DNI and IG count may be new predictive markers with high sensitivity and specificity in detecting axillary metastasis of breast cancer.

Keywords

Breast cancer, axillary lymph node metastasis, delta neutrophil index, immature granulocyte

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