Non dipping pattern frequency and metabolic syndrome relationship according to two different metabolic syndrome diagnostic methods in newly diagnosed hypertensive individuals

Abstract

Aim: The literature presents conflicting data regarding whether the non dipping pattern (NDP) in patients with metabolic syndrome (MS) compared to those without. In our study, we aimed to investigate the MS effect of the NDP in individuals with hypertension. Methods: This prospective study included 117 newly diagnosed hypertensive patients (79 women and 38 men) who were not receiving any anti-hypertensive treatment. MS was evaluated according to the currently used the US National Cholesterol Education Programme Adult Treatment Panel-III definition criteria (MS-ATP-III) and a new diagnostic scoring method (MS-Score). NDP defined, nocturnal blood pressure (BP) fell by <10% from daytime BP Results: The mean age of the patients who met the MS-ATP-III criteria was 53.9+8.1 years. The prevalence of the MS-ATP-III among the study population was 60.6%. The NDP frequency was similar in patients with and without MS-ATP-III, high MS-Score and low MS-Score group (respectively; 44.8%, 47.5%, p=0.79, 44.7%, 46.9%, p= 0.9). The reverse dipping pattern (RDP) frequency was higher in patients with MS-ATP-III compared to those without MS (13.8% and 2.5%, p=0.021), RDP was 10.8% in the high MS-Score group and 8.2% in the low MS-Score group (p=0.66). The LDL (mg/dL) values were higher in those with NDP compared to those without (142.6+32.2, 125.5+28.9, p=0.008). Conclusion: Despite the high prevalence of MS among newly diagnosed hypertensive patients, the prevalence of NDP does not show a different distribution in patients with MS in both the MS-ATP-III and MS-Score method.

Keywords

• Hypertension
• non-dipping pattern
• metabolic syndrome
• reverse dipping pattern
• metabolic score

Yeni tanı almış hipertansif bireylerde iki farklı metabolik sendrom tanı yöntemine göre non dipping patern sıklığı ve metabolik sendrom ilişkisi

Abstract

Amaç: Literatürde, metabolik sendromu (MS) olan hastalarda non dipping paterninin (NDP) olmayanlara kıyasla daha yüksek olup olmadığı konusunda çelişkili veriler bulunmaktadır. Çalışmamızda hipertansiyonu olan bireylerde NDP'nin MS etkisini araştırmayı amaçladık. Yöntemler: Bu prospektif çalışmaya yeni tanı konmuş ve herhangi bir anti-hipertansif tedavi almayan 117 hipertansif hasta (79 kadın ve 38 erkek) dahil edildi. MS, halen kullanılmakta olan US National Cholesterol Education Programme Adult Treatment Panel-III tanım kriterlerine (MS-ATP-III) ve yeni bir tanısal skorlama yöntemine (MS-Skor) göre değerlendirildi. NDP tanımlı, gece kan basıncının (KB) gündüz KB'ye göre <%10 düşmesi. Bulgular: MS-ATP-III kriterlerini karşılayan hastaların yaş ortalaması 53.9+8.1 yıldı. Çalışma popülasyonunda MS-ATP-III prevalansı %60.6 idi. NDP sıklığı MS-ATP-III olan ve olmayan hastalarda, yüksek MS-Skoru ve düşük MS-Skoru grubunda benzerdi (sırasıyla; %44.8, %47.5, p=0.79, %44.7, %46.9, p= 0.9). Ters dalma paterni (RDP) sıklığı MS-ATP-III olan hastalarda MS olmayanlara kıyasla daha yüksekti (%13,8 ve %2,5, p=0,021), RDP yüksek MS-Skoru grubunda %10,8 ve düşük MS-Skoru grubunda %8,2 idi (p=0,66). LDL (mg/dl) değerleri NDP olanlarda olmayanlara kıyasla daha yüksekti (142.6+32.2, 125.5+28.9, p=0.008). Sonuç: Yeni tanı konmuş hipertansif hastalar arasında MS prevalansının yüksek olmasına rağmen, NDP prevalansı hem MS-ATP-III hem de MS-Skor yönteminde MS'li hastalarda farklı bir dağılım göstermemektedir.

Keywords

• Hipertansiyon
• Non-dipping patern
• Metabolik sendrom
• Ters dipping paterni
• Metabolik skor.

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