Akromegalik hastaların kolonoskopik değerlendirmesi: tek merkez deneyimi

Abstract

Amaç: Akromegalili hastalarda kolonoskopik taramanın önemini ve gerekliliğini araştırmak. Yöntemler: Bu çalışmaya Ocak 2008-Ocak 2021 tarihleri arasında Karadeniz Teknik Üniversitesi Gastroenteroloji Anabilim Dalı'nda tarama kolonoskopisi yapılan 82 akromegali hastası ve kontrol grubu olarak da 82 sağlıklı birey dahil edildi. Bulgular: Hastaların akromegali tanısı anında ortalama yaşı 45.71 ± 12.61 idi. Hastaların %51,2'si (n=42) kadındı. Akromegali grubunda polip varlığı ve yetersiz barsak hazırlığı gibi anormal bulgular kontrol grubuna göre anlamlı olarak daha sıktı (p<0,05). Yetersiz barsak hazırlığı saptanan akromegali hastalarında tanı anında ölçülen GH düzeyi anlamlı olarak yüksekti (p<0,05). Polip dışı kolonoskopi bulguları, polip lokalizasyonu, histolojik tipler ve kolorektal kanser açısından iki grup arasında anlamlı fark yoktu. Sonuç: Akromegalili hastalarda (özellikle tanı anında büyüme hormonı yüksek olanlarda) yetersiz barsak hazırlığı oranı daha yüksek olduğundan, barsak hazırlığının standart barsak hazırlığından farklı bir yaklaşımla yapılması bu hasta grubunda daha uygun olacaktır.

Keywords

• Akromegali
• Kolonoskopi
• Büyüme hormonu
• Kolon polipleri

Colonoscopic evaluation of acromegalic patients: a single center experience

Abstract

Aim: To investigate the importance and necessity of colonoscopic screening in patients with acromegaly. Methods: This study included 82 patients with acromegaly and, 82 healthy individuals as the control group who underwent screening colonoscopy in the Gastroenterology Department of Karadeniz Technical University, between January 2008-January 2021. Results:The mean age of the patients was 45.71 ± 12.61 years at the time of acromegaly diagnosis. 51.2% (n=42) of patients were female. Abnormal findings including evidence of polyps, and inadequate bowel preparation were significantly more common in the acromegaly group than the control(p<0,05). The GH level measured at the time of diagnosis was significantly higher in patients with acromegaly diagnosed with inadequate bowel preparation (p<0,05). There was no significant difference between the two groups in non-polyp colonoscopy findings, polyp localization, histologic types and colorectal cancer. Conclusion: It would be reasonable to perform bowel preparation in patients with acromegaly (especially those with high GH at the time of diagnosis) using an approach different from standard bowel preparation, as the rate of inadequate bowel preparation is higher in this group of patients.

Keywords

• Acromegaly
• Colonoscopy
• Growth hormone
• Colon Polips

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