Evaluation of electrocardiographic arrhythmogenicity markers in patients with type 2 diabetes mellitus

Abstract

Aims: Diabetes mellitus (DM) is a chronic disease that progresses with hyperglycemia and the proinflammatory process. The most common complication of DM is cardiovascular disease, and it is known that the risk of arrhythmia increases in patients with DM. The aim of our study was to evaluate the correlation of electrocardiographic arrhythmogenicity markers with HbA1c and fasting blood glucose. Methods: The study included 77 type 2 DM patients and 76 healthy individuals as a control group. Body mass index, HbA1c value, and fasting blood glucose level were recorded for all patients. Corrected QT (QTc), T peak-T end intervals (Tp-e), and Tp-e/QTc values were calculated from 12-lead electrocardiography (ECG). The results were evaluated statistically. Results: The Tp-e interval (p<0.001), QTc interval (p<0.05), and Tp-e/QTc ratio (p<0.001) were significantly prolonged within the DM group compared to the control group. Conclusion: ECG, an inexpensive and reliable diagnostic method, can be used to evaluate the risk of arrhythmia in DM patients. This study concluded that QTc, Tp-e interval, and Tp-e/QTc ratio are markers that can be used to predict arrhythmia risk in DM patients.

Keywords

• Arrhythmia
• Diabetes mellitus
• HbA1c
• QTc
• T peak-T end interval
• Tp-e/QTc

Tip 2 diyabetes mellitus hastalarında elektrokardiyografik aritmojenite indekslerinin değerlendirilmesi

Abstract

Amaçlar: Diyabetes mellitus (DM) hiperglisemi ve proinflamatuvar süreçle ilerleyen kronik bir hastalıktır. DM’ye bağlı en sık görülen komplikasyon kardiyovasküler hastalıklardır. DM hastalarında aritmi riskinin de arttığı bilinmektedir. Çalışmamızın amacı DM tanılı hastalarda elektrokardiyografik aritmojenite indekslerinin kan glukoz regülasyonu ile ilişkisini değerlendirmektir. Yöntemler: Çalışmaya 77 tip 2 DM tanlı hasta ve kontrol grubu olarak 76 sağlıklı birey alındı. Hastaların boy, kilo, beden kitle indeksleri, HbA1c ve açlık kan glukoz düzeyleri kayıt altına alındı. Hastaların 12 derivasyon EKG’leri çekilerek düzeltilmiş QT (QTc), T peak-T end (Tp-e) ve Tp-e/QTc değerleri hesaplandı. Sonuçlar istatistiksel olarak değerlendirildi. Bulgular: Tp-e intervali (p<0.001), the QTc intervali (p<0.05) ve Tp-e/QTc oranı (p<0.001) DM hasta grubunda kontrol grubuna göre anlamlı olarak uzamış olduğu görüldü. Sonuç: Ucuz ve güvenilir bir tanı yöntemi olması nedeniyle EKG, DM hastalarının kardiyak koplikasyonlarının değerlendirilmesinde kullanılmalıdır. Çalışmamızın sonucu olarak QTc, Tp-e intervali ve Tp-e/QTc oranı DM hastalarında aritmi riskini öngörmede kullanılabilecek markerlardır.

Keywords

• Aritmi
• diyabetes mellitus
• QTc
• T peak-T end intervali
• Tp-e/QTc

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