Prognostic evaluation of newborns with neonatal hyperbilirubinemia

Year 2023, , 690 - 693, 31.12.2023

Özlem Özcanlı Çay Özlem Kemer

https://doi.org/10.47582/jompac.1398442

Abstract

Aims: We aimed to investigate the effect of phototherapy treatment by showing that it increases systemic inflammation and changes in NLR (neutrophil count/lymphocyte count), PLO (platelet count/lymphocyte count), systemic Inflammation Index (platelet count × neutrophil count/lymphocyte count ratio) in peripheral blood.
Methods: It was conducted at Balıkesir University Health Practice and Research Hospital between April 2023 and August 2023. 60 babies with a gestational age of ≥36 weeks and a birth weight of ≥2500 g were included in the study.
Results: A statistically significant difference was detected between WBC, lymphocyte count, monocyte count, neutrophil count, lymphocyte/monocyte, systemic inflammatory index before and after phototherapy (p<0.05).
Conclusion: We concluded that phototherapy is associated with the inflammatory process and may increase cytokine release. To investigate these effects of phototherapy, studies on larger populations are needed.

Keywords

Neonatal jaundice, systemic inflammatory index, phototherapy

Prognostic evaluation of newborns with neonatal hyperbilirubinemia

Abstract

Amaç: Fototerapi tedavisinin sistemik inflamasyonu ve NLR (Nötrofil sayısı/Lenfosit sayısı), PLO (Platelet sayısı/Lenfosit sayısı), Sistemik İnflamasyon İndeksindeki (Platelet sayısı x Nötrofil sayısı/Lenfosit sayısı) değişiklikleri artırdığını göstererek etkisini araştırmayı amaçladık. sayım oranı) periferik kanda.
Yöntemler : …… Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi'nde Nisan 2023-Ağustos 2023 tarihleri arasında gerçekleştirildi. Çalışmaya gebelik yaşı ≥36 hafta ve doğum ağırlığı ≥2500 g olan 60 bebek dahil edildi.
Bulgular: Fototerapi öncesi ve sonrası WBC, lenfosit sayısı, monosit sayısı, nötrofil sayısı, lenfosit/monosit, sistemik inflamatuar indeks arasında istatistiksel olarak anlamlı fark tespit edildi (p<0,05).
Sonuç: Fototerapinin inflamatuar süreçle ilişkili olduğu ve sitokin salınımını artırabileceği sonucuna vardık. Fototerapinin bu etkilerini araştırmak için daha büyük popülasyonlarda çalışmalara ihtiyaç vardır.

Keywords

Yenidoğan sarılığı, sistemik inflamatuar indeks, fototerapi

References

• Muchowski KE. Evaluation and treatment of neonatal hyperbilirubinemia. Am Fam Physician. 2014;89(11):873-878.
• “American Academy of Pediatrics Clinical Practice Guideline Subcommittee on Hyperbilirubinemia Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation,” 2004. Available from: www.aap.org/family/jaundicefaq.
• Kurt A, Tosun MS, Altuntaş N, Erol S. Effect of phototherapy on peripheral blood cells in hyperbilirubinemic newborns. J Coll Physicians Surg Pak. 2020;30(5):547-549.
• Kurt A, Aygun AD, Citak Kurt AN, Godekmerdan A, Akarsu S, Yilmaz E. Use of phototherapy for neonatal hyperbilirubinemia affects cytokine production and lymphocyte subsets. Neonatology. 2009;95(3):262-266 doi: 10.1159/000171216
• Sajid A, Mahmood T, Riaz S, Nabi SG. Phototherapy in hyperbilirubinemic neonates; does it affect platelet count? Ann King Edward Med Uni. 2016;22(3):215-220.
• Bolat F, Uslu S, Bulbul A, Comert S, Can E, Nuhoglu A, Evalution of term newborns hospitalized in our NICU with the diagnosis of indirect hyperbilirubinemia. J Child. 2010;10(2):69-74.
• Altuntaş N, Akpınar Tekgündüz S, Özkan Kırgın B, Doğan ÖC, Kışlal FM. Is the phototherapy requirement in neonatal hyperbilirubinemia due to Ab0 incompatibility predictable? Turk J Pediatr Dis. 2019;13(5):330-334. doi: 10.12956/tjpd.2018.389
• Aydın B, Beken S, Zenciroğlu A, Dilli D, Özyazıcı, E, Okumuş, N. Effect of conventional and LED phototherapy on eosinophil, albumin and uric acid levels in newborns with severe indirect hyperbilirubinemia. Paper presented at: 21st National Neonatology Congress; 13-17 April, 2013; Antalya, Turkey.
• Kaplan M, Bromiker R, Hammerman C. Severe neonatal hyperbilirubinemia and kernicterus: are these still problems in the third millennium? Neonatol. 2011;100(4):354-362. doi: 10.1159/000330055
• Çoban A, Kaynak Türkmen M, Gürsoy T. Turkish neonatal society guideline to the approach, follow-up, and treatment of neonatal jaundice. Turk Pediatri Ars. 2018;53(Suppl 1):S172-S179. doi: 10.5152/TurkPediatriArs.2018.01816
• Erdeve Ö, Okulu E, Olukman Ö, et al. The Turkish neonatal jaundice online registry: a national root cause analysis. PLoS One. 2018;13(2):e0193108 doi: 10.1371/journal.pone.0193108
• Jahanshahifard S, Ahmadpour-Kacho M, Pasha Y. Effects of phototherapy on cytokines levels and white blood cells in term neonate with hyperbilirubinemia. J Clin Neonatol. 2012;1(3):139-142. doi: 10.4103/2249-4847.101696
• Yılmaz FH, Kara B, Ertan K. effects of phototherapy on hematological parameters in newborns with indirect hyperbilirubinemia. Abant Med J. 2022;11(3):283-294. doi: 10.47493/abantmedj.1065601
• Li T, Dong G, Zhang M, et al. Association of neutrophil-lymphocyte ratio and the presence of neonatal sepsis. J Immunol Res. 2020;2020:7650713. doi: 10.1155/2020/7650713
• Khera S, Gupta R. Incidence of thrombocytopenia following phototherapy in hyperbilirubinemic neonates. Med J Armed Forces India. 2011;67(4):329-332. doi: 10.1016/S0377-1237(11)60078-6
• Pishva N, Pishva H. Incidence of thrombocytopenia in hyperbilirubinemic neonates during phototherapy. Acta Med Iranica. 2000;38(1):7-9.
• Adanır H, Akıncıoğlu P. The importance of systemic immune-inflammation index in ulcerative colitis. Dicle Med J. 2022;49(3):521-528. doi : 10.5798/dicletip.1170395
• Ercan Z, Aylı MD. Systemic immune inflammation index can predict mortality in dialysis patients. Turk J Clin Lab. 2023;14(2):392-398. doi : 10.18663/tjcl.1278035
• Çetinkaya HB, Çay F. Usability of NLR in differentiating simple and severe cholecystitis in emergency department admissions. Van Med J. 2021;28(4):502-506.
• Çay F, Çetinkaya HB. The usability of shock index and lactate in predicting mortality in multitrauma patients presenting to the emergency department. Anatolian Curr Med J. 2022;4(2):185-189.
• Khan NM, Poduval TB. Immunomodulatory oath immunotoxic effects of bilirubin: molecular mechanisms. J Leukocyte Biol. 2011;90(5):997-1015. doi.org/10.1189/jlb.021107