Prognostic evaluation of newborns with neonatal hyperbilirubinemia

Abstract

Amaç: Fototerapi tedavisinin sistemik inflamasyonu ve NLR (Nötrofil sayısı/Lenfosit sayısı), PLO (Platelet sayısı/Lenfosit sayısı), Sistemik İnflamasyon İndeksindeki (Platelet sayısı x Nötrofil sayısı/Lenfosit sayısı) değişiklikleri artırdığını göstererek etkisini araştırmayı amaçladık. sayım oranı) periferik kanda. Yöntemler : …… Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi'nde Nisan 2023-Ağustos 2023 tarihleri arasında gerçekleştirildi. Çalışmaya gebelik yaşı ≥36 hafta ve doğum ağırlığı ≥2500 g olan 60 bebek dahil edildi. Bulgular: Fototerapi öncesi ve sonrası WBC, lenfosit sayısı, monosit sayısı, nötrofil sayısı, lenfosit/monosit, sistemik inflamatuar indeks arasında istatistiksel olarak anlamlı fark tespit edildi (p<0,05). Sonuç: Fototerapinin inflamatuar süreçle ilişkili olduğu ve sitokin salınımını artırabileceği sonucuna vardık. Fototerapinin bu etkilerini araştırmak için daha büyük popülasyonlarda çalışmalara ihtiyaç vardır.

Keywords

• Yenidoğan sarılığı
• sistemik inflamatuar indeks
• fototerapi

Prognostic evaluation of newborns with neonatal hyperbilirubinemia

Abstract

Aims: We aimed to investigate the effect of phototherapy treatment by showing that it increases systemic inflammation and changes in NLR (neutrophil count/lymphocyte count), PLO (platelet count/lymphocyte count), systemic Inflammation Index (platelet count × neutrophil count/lymphocyte count ratio) in peripheral blood. Methods: It was conducted at Balıkesir University Health Practice and Research Hospital between April 2023 and August 2023. 60 babies with a gestational age of ≥36 weeks and a birth weight of ≥2500 g were included in the study. Results: A statistically significant difference was detected between WBC, lymphocyte count, monocyte count, neutrophil count, lymphocyte/monocyte, systemic inflammatory index before and after phototherapy (p<0.05). Conclusion: We concluded that phototherapy is associated with the inflammatory process and may increase cytokine release. To investigate these effects of phototherapy, studies on larger populations are needed.

Keywords

• Neonatal jaundice
• systemic inflammatory index
• phototherapy

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